In 6-OHDA + MitoPark mice: Li et al. (www.nature.com/articles/s41...) report that (1) DBS inhibits STN neurons, reflecting greater drops in pre-synaptic glutamate vs. GABA release, and (2) chemogenetic inhibition of STN replicates the restorative effects of DBS on locomotion and rotarod tests.
10.01.2026 17:26 — 👍 1 🔁 0 💬 0 📌 0
New ephys + modeling paper suggesting that lateral inhibition explains paradoxical SNr activation following optogenetic activation of dSPNs:
Synaptic integration and competition in the substantia nigra pars reticulata—An experimental and in silico analysis | PNAS www.pnas.org/doi/full/10....
31.12.2025 10:48 — 👍 0 🔁 0 💬 0 📌 0
While these results await empirical validation, they raise interesting questions. To inhibit reflexes, what are the contributions of descending commands vs. local interactions? And do under-controlled reflexes contribute to slow/altered limb trajectories in movement disorders, including PD? (4/4)
25.12.2025 08:25 — 👍 0 🔁 0 💬 0 📌 0
(2) Two modeled mechanisms (coordinated activation of α- and γ-motoneurons, or inhibition of γ-motoneurons by α-motoneuron collaterals) can effectively reduce such disruption. (3) However, neither mechanism is, in their words, a panacea -- meaningful disruption remained for some reaches. (3/4)
25.12.2025 08:25 — 👍 0 🔁 0 💬 1 📌 0
Niyo et al. ask whether/how the nervous system prevents velocity-dependent stretch reflexes from disrupting voluntary movement. Observations from their model of a macaque arm: (1) Left disinhibited, stretch reflexes would substantially disrupt movements.
(2/4)
25.12.2025 08:25 — 👍 0 🔁 0 💬 1 📌 0
Happy Holidays. Here's a 2024 PNAS modeling paper that merits wider awareness:
A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement | PNAS www.pnas.org/doi/10.1073/...
(1/4)
25.12.2025 08:25 — 👍 0 🔁 0 💬 1 📌 0
![Comment Template
COMMENT SUBMISSION INSTRUCTIONS: All submissions must include the agency name and docket number or RIN for this rulemaking. Please arrange and identify your comments on the regulatory text by subpart and section number; if your comments relate to the supplementary information, please refer to the heading and page number. All comments received will be posted publicly without change, including any personal information provided. To ensure that your comments will be considered, you must submit them on or prior to May 23, 2025 at online to the Federal Register. Before finalizing this rule, OPM will consider all comments within the scope of the regulations received on or before the closing date for comments. OPM may make changes to the final rule after considering the comments received.
COMMENT STARTER: The example below is meant to get you started with your own comment. Feel free to use it with only minimal changes, to go a different direction, or anything in between. Because OPM has to consider each comment, unique comments add value to the process but all comments relevant to the proposed rule and grounded in thoughtful analysis or real experience are helpful.
[DATE]
RE: Public Comment in Response to Improving Performance, Accountability and Responsiveness in the Civil Service [Docket No. OPM–2025–0004]
I am writing to express my deep concern regarding the effort to reclassify specific fe](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:et2wciooy67fjldjcvls34c6/bafkreicyl4znsl4b2bs6eoj24pre43elov63wmmx2suinlli2cpsposfyy@jpeg)
Comment Template
COMMENT SUBMISSION INSTRUCTIONS: All submissions must include the agency name and docket number or RIN for this rulemaking. Please arrange and identify your comments on the regulatory text by subpart and section number; if your comments relate to the supplementary information, please refer to the heading and page number. All comments received will be posted publicly without change, including any personal information provided. To ensure that your comments will be considered, you must submit them on or prior to May 23, 2025 at online to the Federal Register. Before finalizing this rule, OPM will consider all comments within the scope of the regulations received on or before the closing date for comments. OPM may make changes to the final rule after considering the comments received.
COMMENT STARTER: The example below is meant to get you started with your own comment. Feel free to use it with only minimal changes, to go a different direction, or anything in between. Because OPM has to consider each comment, unique comments add value to the process but all comments relevant to the proposed rule and grounded in thoughtful analysis or real experience are helpful.
[DATE]
RE: Public Comment in Response to Improving Performance, Accountability and Responsiveness in the Civil Service [Docket No. OPM–2025–0004]
I am writing to express my deep concern regarding the effort to reclassify specific fe
All right, scientists. 🧪
The Trump administration is trying to break scientific expertise in the civil service. This will affect #NIH program staff. Red 🚨.
It's your job to submit comments by 5/23 saying that's a terrible idea!
This group has info: www.friendsofbls.org/comment-temp...
05.05.2025 02:11 — 👍 193 🔁 104 💬 4 📌 2
Please take a moment to read and sign this excellent letter. Over 3,500 signature so far!
02.04.2025 15:47 — 👍 183 🔁 50 💬 7 📌 1
(2) Under the heading ‘‘Department of Health and Human Services—Health Resources and Services Admin12 istration—HRSA-Wide Activities and Program Support’’, by substituting ‘‘$219,588,000’’ for ‘‘$1,110,376,000’’ and by substituting ‘‘$0’’ for ‘‘$890,788,000’’
SEC. 1905. Notwithstanding section 1101 of this Act, the level for ‘‘Department of Health and Human Services—National Institutes of Health—NIH Innovation Account, CURES Act’’ shall be applied by substituting ‘‘$127,000,000’’ for ‘‘$407,000,000’’.
Under the heading ‘‘Department of Health and Human Services—Administration for Children and Families—Children and Families Services Programs’’, by substituting ‘‘$14,789,089,000’’ for ‘‘$14,829,100,000’’ and by substituting ‘‘$0’’ for ‘‘$40,011,000’’
What’s in yesterday's House Continuing Resolution? Major shifts in U.S. health spending you should know about:
HRSA cut by $891 million
NIH CURES Act cut by $280 million
Children & Families Services cut by $40 million
These cuts hit essential services and future innovation. 🧵⬇️
09.03.2025 17:22 — 👍 300 🔁 181 💬 9 📌 10
Hearing from NIH intramural people today that the travel ban is not lifted and the external communication ban is not lifted. (More info was initially promised for Feb 1.)
Some exceptions have been carved out for meetings with ongoing collaborators.
But no seminar visits or conferences.
Bad! 🧪
03.02.2025 19:31 — 👍 177 🔁 54 💬 3 📌 5
This account is for sharing info with US scientists, both extramural and intramural to NIH, about attacks on science in the US.
Education is power, and we can help advocate for science and medicine together. 💪🧪
We are a team of NIH people. Please ask us questions you might have.
30.01.2025 01:18 — 👍 2169 🔁 807 💬 92 📌 70
Neurology and brain imaging.
ORCID: 0000-0002-0945-5779
Health Equity Scientist, Bethesda Declaration signer, work at NIH, speak in my personal capacity, photo: AP/Jose Luis Magana
Also on:
https://www.instagram.com/jmnorton
https://www.tiktok.com/@jennajmn
https://linktr.ee/declarationsofdissent
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
The CenteR for Advancing Neurotechnological Innovation to Application (CRANIA) unites research, clinical, and academic expertise to advance neuromodulation technologies and interventions at a world-class center in Toronto.
TogetherForSharon® In memory of my Mother, Sharon to voice awareness & hope for a PD cure. http://www.togetherforsharon.com
Co-Creating Ireland's Public Involvement in Open Research Roadmap
ENGAGED is building a national roadmap to shape public involvement in open research in Ireland. We believe that research can and does play an important role in tackling societal challenges.
🧠 The Krembil Brain Institute, part of the University Health Network (UHN), Canada's #1 Hospital, is dedicated to advancing research and clinical care for those living with diseases and disorders of the brain and spine.
🔗 https://linktr.ee/krembil
The State Universities Retirement
System of Illinois is a public pension
plan, established in 1941.
Father, husband, scientist
Brain Canada is a national non-profit organization that enables and supports excellent, innovative, paradigm-changing brain research in Canada. #BrainCanada
PGHS is a group of healthcare workers, public health experts, clinicians, and scientists in Pittsburgh mobilizing to protect equitable healthcare access, intellectual freedom, research funding, and democracy.
Neurology professor at the University of Cincinnati, an advocate of precision and rescue medicines for Parkinson's & Alzheimer's. Author #BrainFables.
NY Times Besting Author of the Parkinson’s Plan, Medical Advisor Parkinson Foundation, Author 15 books http://pdplan.org Distinguished Professor and Director of the Fixel, Associate Editor JAMA Neurology, co-founder @DBSThinkTank
Multi-site, transformative preclinical evaluation of novel neurotherapeutics through a Government of Canada $24M New Frontiers In Research grant. Check out our website tridentpreclinicaltrials.org for more info or email info@tridentpreclinicaltrial.org!
Brains, Data and Science
Prof in Computational Neuroscience at Western University
Cerebellum and Motor Control
Mobilizing the fight for science and democracy, because Science is for everyone 🧪🌎
The hub for science activism!
Learn more ⬇️
http://linktr.ee/standupforscience
Technology, Parkinson’s, #sophiefromromania
Husband, Father, Grandfather, Datahound, Dog lover, Fan of Celtic music, Former NIGMS director, Former EiC of Science, Stand Up for Science advisor, Shenanigator, Pittsburgh, PA
NIH Dashboard: https://jeremymberg.github.io/jeremyberg.github.io/index.html
Facts & strategy, in an authoritarian takeover.
Rightwing billionaires want to privatize NIH and use it to control universities.
We work to cure diseases like cancer.
Pers views. #science #medicine
Mathematician, writer, Cornell professor. All cards on the table, face up, all the time. www.stevenstrogatz.com
