CAP-IT

At today’s Bioinformatics & Computational Biology #CAPITWGMeeting, WG Chair Dr. Alan Hutson of @roswellpark.bsky.social k provided working group updates, and Dr. Li Zhang of Fox Chase Cancer Center presented on “Bayesian Compositional Models for Analyzing Microbiome Data.”

Dr. Yongfeng He, CAP-IT nvestigator in Dr. Vivek Mittal Lab at Weill Cornell Medicine, will present their vaccine research at the Major Symposium 5 " New Breakthroughs in TCR Engineering" at the AACR Immuno-Oncology Conference in Los Angeles.
🗓 Feb 20 | 9:30–11:00 AM PT
www.aacr.org/meeting/aacr...

🧬 CIP-Net Project Spotlight
UG3CA290454 is developing a preventive cancer vaccine for people with inherited BRCA1/2 mutations, using chimeric RNA-derived neoantigens to stop breast cancer before it forms.
👉Learn more on the CIP-Net website: www.nci-cipnet.org/en/members/u...

Join us at the CAP-IT Summit on March 30, 2026! The event is open to the public.
ncicapit.org/en/cap-it-su...

Registration for the NCI CAP-IT Annual Summit: March 30, 2026 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

Save the date! The #CAPITSummit is happening on March 30, 2026.
A full day of science, strategy, and community—bringing together researchers, clinicians, and advocates to advance cancer prevention and interception.
Register now and join us:
tinyurl.com/5c6snwyz

Registration for the NCI CAP-IT Annual Summit: March 30, 2026 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

Save the date! The hashtag#CAPITSummit is happening on March 30, 2026.
A full day of science, strategy, and community - bringing together researchers, clinicians, and advocates to advance cancer prevention and interception.
Register now and join us:
tinyurl.com/5c6snwyz

#CAPITSCMeeting

Rewiring natural killer cells for next-generation cancer therapies Harnessing the cytotoxic potential of natural killer (NK) cells for cancer immunotherapy has proven challenging. In this issue of Cancer Cell, Biederstädt et al. and Nikolic et al. utilize genome-wide CRISPR screening to uncover novel regulators of NK cell function, paving the way for developing next-generation NK cell therapies.

Rewiring natural killer cells for next-generation cancer therapies

At today’s #CAPIT Bioinformatics & Computational Biology WG meeting, Dr. Chi Zhang of University of Nebraska - Lincoln presented his work on AI-powered image feature extraction and data synthesis in pancreatic cancer.

The latest CAP-IT Newsletter is out!
It features highlights and reports from the July 2025 CAP-IT Summit, along with updates on network progress:
indd.adobe.com/view/32541c2...

New Tools and Resources from the NCI Data Sharing Hub , now added to the CAP-IT Shared Resources Catalog. Check it out and all NCI/NIH Shared resources at the link below:
ncicapit.org/en/resources...

The amazing @ptorresayuso.bsky.social from #FoxChaseCancerCenter and #TempleUniversity presenting his exciting research at the @ncicapit.bsky.social summit

a poster that says out of this world ALT: a poster that says out of this world

The 2025 Annual @ncicapit.bsky.social Summit is #Outofthisworld good!!! The plenary speaker #EvaSzabo, the keynote presentation by #RafiAhmed followed by AI guru #ChanghueiYang & #force ‘s #SueFredman & panelist for #EmergingTechnologies lead by the amazing #ShannonHughes were extraordinary!!!

Don't wait - register now for the CAP-IT Virtual Annual Summit on July 24, 2025!
Open to the public with exciting talks on cancer prevention and interception.
🔗 Register: tinyurl.run/M3wsBV
ℹ️ Info: ncicapit.org
📧 CAP-IT@nih.gov
#CancerPrevention #NCICAPIT

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses an...

A personalized neoantigen vaccine + Montanide/poly-ICLC/ipilimumab reshapes the T cell landscape in melanoma patients:
- Strong CD8+ responses
- TCR repertoires expanded beyond anti–PD-1
- Vaccine-specific TILs identified post-treatment

www.cell.com/cell/abstrac...?
#Neoantigen #Melanoma #Tcells

We have a great lineup of events this summer, we hope you can join us!

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

New in @cellcellpress.bsky.social : Exercise boosts immune checkpoint inhibitor (ICI) efficacy in #Melanoma via microbiota-derived formate, which enhances CD8⁺ T cell immunity through Nrf2 activation.

cell.com/cell/abstrac...
#Immunotherapy #Microbiome #CancerResearch

EHA–EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma Nature Reviews Clinical Oncology, Published online: 07 July 2025; doi:10.1038/s41571-025-01041-xIn these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide key treatment recommendations for patients with smouldering multiple myeloma, and newly diagnosed or relapsed and/or refractory multiple myeloma, addressing the use of established drugs and novel immunotherapies as well as the management of disease-specific and treatment-related complications and adverse events.

Now online!

Cancer vaccines and the future of immunotherapy Vaccines have had a major impact on the control of infectious disease, most recently by helping to combat the COVID-19 pandemic. Prophylactic cancer vaccines have prevented several malignancies by pro...

New in @thelancet.com : A comprehensive review on cancer vaccines and their role in shaping the future of immunotherapy.
Read here:
www.thelancet.com/journals/lan...

New @thelancet.com - Retifanlimab with carboplatin and paclitaxel for locally recurrent or metastatic squamous cell carcinoma of the anal canal (POD1UM-303/InterAACT-2): a global, phase 3 randomised controlled trial

www.thelancet.com/journals/lan...

#GastroSky #MedSky #OncSky

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy - PubMed Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapi...

New study in Cell: HIF upregulates endogenous retroviruses in clear cell kidney cancer, generating tumor-specific antigens. ERV-targeting T cells show promise for immunotherapy and HIF stabilizers may unlock similar responses in other tumors. #CAPITPublication
pubmed.ncbi.nlm.nih.gov/40023154/

Registration for the NCI CAP-IT Annual Summit: July 24, 2025 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

We’re excited to announce that the CAP-IT Virtual Annual Summit will be held on July 24, 2025!
Register here:
docs.google.com/forms/d/e/1F...

For more information, visit : ncicapit.org or email: CAP-IT@nih.gov #CancerPrevention #NCICAPIT

Recent advances in therapeutic cancer vaccines - Nature Reviews Cancer Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development and clinical translation continues to face challenges. Here, Zaidi, Jaffee and Yarchoan summarize the failures of cancer vaccines of the past, to highlight recent advancements in the field.

REVIEW 🚨

Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development + clinical translation continue to face challenges. Here, Zaidi, Jaffee & Yarchoan summarize this & highlight advances in the field.

📖 👇

Addressing the gaps in cancer screening for LGBTQ+ individuals Nature Reviews Cancer, Published online: 28 May 2025; doi:10.1038/s41568-025-00835-6Individuals of sexual and gender minorities (SGMs), particularly transgender and nonbinary individuals, face substantial disparities in cancer screening. Here, Davison et al. explore these challenges and call for inclusive healthcare practices and policies to ensure equitable access to cancer screening.

NEW content online!

Small-molecule RNA therapeutics to target prostate cancer Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the select translation of key oncogenes, androgen receptor (AR), and HIF1α through remodeling their 5′ UTR RNA structure. Zotatifin enhances anti-androgen and radiotherapy sensitivity, highlighting a promising anti-cancer treatment.

Small-molecule RNA therapeutics to target prostate cancer

Translation dysregulation in cancer as a source for targetable antigens Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasing both tumor immunogenicity and sensitivity to ICB therapy. TYW2 expression levels in patients with melanoma predict clinical outcomes, highlighting translation regulatory factors as immunotherapy targets.

Translation dysregulation in cancer as a source for targetable antigens

Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception Zhu et al. reveal coordinated interplay between innate and adaptive immunity in the transition from precancer to invasive lung cancer. TIM-3 upregulation peaks at precancer stage and its blockade enhances anti-tumor immunity while inhibiting lung precancer progression, suggesting TIM-3 as a potential target for lung precancer interception.

Online Now: Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

🚨 The 2025 #CAPITSummit is coming!
🗓️ Agenda is live & public registration is now open!
🔗 Explore the program & sign up today via the CAP-IT web portal:
ncicapit.org/en/cap-it-su...

May is Brain Tumor Awareness Month. Here's what you should know about the brain and brain tumors.