High-content pipeline evaluating YAP/TAZ-TEAD inhibitors in mesothelioma using isogenic models,advanced morphological profiling & genetic response analysis,revealing drug specificity & compensatory pathways @gram-lab.bsky.social @edinuni-irr.bsky.social

• Genetic Compensation Identified: Reveals adaptive responses that may limit inhibitor efficacy.

•. Highlight the importance of having genetic controls, when assessing hippo-pathway targeting compounds.

• Advanced Morphological Profiling: Implements Cell Painting to analyse cellular changes and detect off-target effects.
• Scalable Drug Screening Tool: Provides a clinically relevant and adaptable framework for future Hippo pathway drug discovery.

Some highlights

• Comprehensive Inhibitor Evaluation: Head-to-head comparison of existing #YAP/TAZ-TEAD inhibitors in a mesothelioma-relevant context.
• Isogenic Cell Models: Utilise matched genetic models to accurately assess drug specificity and on-target effects.

Paper is out!

We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org

www.life-science-alliance.org/content/8/10...

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.

Our #mesothelioma work featured

Vienna anyone? IMP #GroupLeader position open!

If you’re working in animal comparative physiology or biomechanics and are within 5 years of setting up your first lab, apply for our JEB ECR Visiting Fellowships & Research Partnership Kickstart Travel Grants. Deadline 1 December

biologists.com/grants/kicks...

biologists.com/grants/ecr-v...

Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma As the core, tumorigenic downstream effectors of the Hippo signalling pathway, YAP/TAZ and the TEAD family of transcription factors represent attractive targets for drug discovery efforts within cance...

Our preprint from last week.

Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...

#mesothelioma, #cell-painting and #Hippopathway

Exciting #PhD openings. Please spread the word, and/or consider applying!

Excellent opportunities

1) UKRI AI based PhD program
www.ai4biomed.io/research/pro...

2) Precision Medicine Program
usher.ed.ac.uk/precision-me...

Back from the excellent #Hippopathway conference in Florida. What a lovely bunch of people, and exciting developments in the field. #Cancer, #Regeneration and #Fibrosis etc.
Great Science, and even saw a "rocket". Hard to beat for the next conference....