Henry McSorley

#goals

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...

real bravery

Done! 7 laps, 67 km. To be clear, the race is still going on, IM done. 3000 calories - could eat… strava.app.link/8fs8DA6u0Wb

a man wearing glasses and a hat is laughing with his tongue out ALT: a man wearing glasses and a hat is laughing with his tongue out

A Marshall just shouted “only 3 hours left!” And the look I gave him did this.

a man with a mustache is laying on a couch and says screaming ALT: a man with a mustache is laying on a couch and says screaming

Lap 5 update

Lap 4 update: oh no

Currently done lap 3 and has gone exactly as above, with a major crash due to overexcitement. (Bike and rider are fine)
I plan to learn nothing from this.

My usual performance goes:
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up

Picture of a mtb race

Doing the Glentress 7 today - 7h mountain bike race. I plan to become a machine which turns peanut butter and jam sandwiches into laps.

We're looking for a Lead Scientist to join Flow Cytometry Centre in Aberdeen! Fantastic opportunity to deliver services, work with varied research groups, promote cytometry and further develop the facility. Aberdeen is a great place to live/work- APPLY NOW www.abdnjobs.co.uk/vacancy/cyto...

Thats where the story ends at the moment - we would love to look at the in vivo effects of HpBoRB against RELM-beta (does it suppress RELM-beta's activity?) but we ran out of time in Viv's PhD. If anyone has any interesting RELM-beta assays they would like to try HpBoRB in, hit us up!

We then confirmed this binding in a number of ELISA, SPR and gel filtration assays - it is a high-affinity (subnanomolar) interaction.

Screen of parasite proteins binding to a range of host immune proteins

We screened the CCP domain protein family to see if there were other host immune factor binders, using an AVEXIS protein-protein interaction screen. The screen confirmed that HpBARI binds ST2, and that TGM1 binds TGFBR2 (reassuring) and identified one new hit - a protein which bound RELM-beta.

Graph showing number of CCP domain proteins in different helminth genomes - H. polygyrus bakeri is an outlier with far more CCP domain proteins than any other worm.

This story started when we realised that all of the immunomodulators we had identified from Hpb (HpARI, HpBARI and TGM) were related in their domain structure - all consist of strings of CCP domains. Turns out the CCP domain family is massively (and uniquely) expanded in the Hpb genome.

Graphic abstract of paper showing the identification of HpBoRB, a worm protein which binds RELM-beta

Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...

Congratulations Tara, brilliant work!

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social

In a moment like this, when tensions are high, part of the job of the president is to remind us of the ties that bind us together.

Japan has a wrestling camp for kids where at the end they have a show match in front of their parents to show off what they learned.

Thought you'd enjoy this.

Hominid re-diversification

Pangolin taking a mud bath: #AGoodPlace

Source: www.reddit.com/r/NatureIsFu...

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

I have marked 6 MSc theses in 2 days and I cant read any more words. No more words thank you.

Or acronyms. Especially acronyms.

Great postdoc opportunity available in the Konkel lab in Manchester!

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity IL-25 treatment induces persistent adaptation of the small intestine, which is maintained by ILC2s with functional and epigenetic qualities of immune memory. Effector-memory ILC2s arise in multiple ti...

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity

Cell www.cell.com/cell/fulltex...

"chatGPT 5 is like having a bunch of phds in your pocket" here's ten trillion dollars

"bluesky is having an *actual* bunch of phds in your pocket" dying platform. it disgusts me

Epithelial Memory After Respiratory Viral Infection in Mice Results in Prolonged Enhancement of Antigen Presentation RSV infection induces lasting epigenetic and transcriptional changes in LECs, upregulating MHC-I and MHC-II, further amplified by LPS exposure. This is accompanied by increased antigen uptake, proc...

Super proud that my PhD paper is finally out! doi.org/10.1111/all.... RSV leaves long-lasting marks on the lung, potentially boosting future immune responses but also contributing to allergen sensitisation.

Me: (birdwatching) ooo a brown one