Dissociated VP7 monomers form a single, large, cooperative pore, seen both in cells and in liposomes. An amphipathic VP7 helix is sufficient for perforation, enabling rapid DLP release and immediate viral transcription in the cytosol (3/3).
27.01.2026 17:06 — 👍 2 🔁 1 💬 0 📌 0
We show that entry is a two-step membrane insertion process. VP4 spikes switch from upright (attachment) to reversed (insertion of foot domain). This triggers Ca²⁺ leakage from vesicle, Ca2+ signaling and ultimately VP7 dissociation (2/3)
27.01.2026 17:04 — 👍 4 🔁 2 💬 1 📌 0
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
27.01.2026 17:03 — 👍 70 🔁 18 💬 2 📌 1
Plants, Pathogens and Procrastination
Emmy Noether Fellow at ZMBP
Postdoctoral researcher in the Lewandowski, Stansfeld and Dowson labs @ Warwick | Former postdoctoral researcher in the Marrink lab @ Groningen University | Views are my own | She/her 🏳️🌈
https://orcid.org/0000-0003-2006-5015
PhD student at the @memprotlabuv.bsky.social
University of Valencia @uv.es
Especially interested in the biogenesis of viral proteins.
Group leader at the Max Planck Institute for Biology in Tuebingen. Adaptive evolution of filamentous plant pathogens 🌾🍄🧬. Love nature and music 🎸🥁 dogfather 🐕
Postdoctoral Scholar in the Barad Lab at Oregon Health and Science University, where I study cytoskeletal remodeling in response to intracellular infection using Cryo-electron tomography. Views are my own.
Cell biologist working on malaria parasites and interested in host pathogen interactions, imaging, teaching, space exploration, gardening.
CryoFIB Development and In situ structural biology. NPC and TE enthusiast. Drosophilist but ready to switch to wherever biology takes us
Getting to enjoy science with a group at IMBA/IMP of the Vienna BioCenter https://www.imp.ac.at/groups/sven-klumpe
Combining excellence & innovation in clinical care, research & education. #CareDiscoverTeach Our Social Media Policy: http://bit.ly/1vlHtPc
Max Planck Institute investigating the structure and function of proteins - from individual molecules to whole organisms.
Currently postdoc @briggsgroup.bsky.social @mpibiochem.bsky.social | PhD @ScheuringLab @weillcornell.bsky.social | #biophysics, #cryEM, #cryoET, #AFM
Host-pathogen interactions, structural biology, protein design and more. Assistant Professor at Duke University.
www.wrapplab.org
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
Virologist. Professor. Cambridge, UK
https://www.immunology.cam.ac.uk/staff/professor-sam-wilson
https://tinyurl.com/samjwilsonscholar
Postdoc in the Abraham Lab @HMS | Viruses & CryoET/EM | she/they 🏳️🌈
Scientist interested in structural biology, vaccine design, antibodies, protein engineering… pretty much everything
Assistant Professor in the UC Berkeley Department of Molecular and Cell Biology, mtDNA obsessed, mother to the Lord of Chaos, she/her, personal account, views do not reflect those of my employer.
https://www.samlewis-phd.com/
biophysicist trying to understand how insects smell things | Postdoc - del Mármol lab @ Harvard Medical school | PhD - Gonzalez lab @ Columbia University
Assistant Professor @ OHSU • Structural Biologist • Programmer • Coffee Roaster • he/his/him • Cryo-electron tomography, membranes, infectious bacteria, mitochondria. #teamtomo #cryoET http://tomo.science
Biologist fascinated by and specialized in cellular cryo-electron tomography @ljiresearch.bsky.social. #teamtomo, #cryoET, #virology
