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Daniel Wrapp

@wrapplab.bsky.social

Host-pathogen interactions, structural biology, protein design and more. Assistant Professor at Duke University. www.wrapplab.org

298 Followers  |  73 Following  |  1 Posts  |  Joined: 12.11.2024  |  1.4787

Latest posts by wrapplab.bsky.social on Bluesky

It's really real 😭😭😭 Huge thanks to Wrapper's Delight ( @wrapplab.bsky.social ) and T-Pain ( @timothysheahan.bsky.social ) for everything. Working on this together was the best part of 2025!

10.01.2026 14:42 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...

10.01.2026 13:06 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

www.nature.com/articles/s42...

@wrapplab.bsky.social

09.01.2026 13:22 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

19.11.2025 19:04 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

08.10.2025 19:59 β€” πŸ‘ 222    πŸ” 34    πŸ’¬ 32    πŸ“Œ 2
Episode 13: Using structure-based design to develop novel antiviral therapeutics | Creating Memory: Vaccines & Immunity We talk with Dr. Daniel Wrapp, Assistant Professor Assistant Professor at the Duke Human Vaccine Institute at Duke University School of Medicine, NC, who uses structure-based design to develop novel t...

As part of our 2025 β€œRising Stars in #Vaccinology and #Immunity to #Microbes” seminar series, we spoke with Dr. Daniel Wrapp @wrapplab.bsky.social who uses structure-based design to develop new #antiviral therapies. cvimp.podbean.com/e/episode-13...

02.09.2025 02:13 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

18.06.2025 14:24 β€” πŸ‘ 69    πŸ” 23    πŸ’¬ 2    πŸ“Œ 2

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen www.biorxiv.org/content/10.1101/2025.05.19.654955v1 #cryoEM

20.05.2025 07:10 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...

Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC.

www.biorxiv.org/content/10.1...

19.05.2025 10:34 β€” πŸ‘ 18    πŸ” 11    πŸ’¬ 1    πŸ“Œ 2

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