Scott Rush

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...

🚨 New paper alert! 🚨

Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

Predicting the translation efficiency of messenger RNA in mammalian cells Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:

Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l

Design of intrinsically disordered region binding proteins Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such syst...

www.science.org/doi/10.1126/...

Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.

New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals

Let me show you 🧵 (1/5)

Link: www.science.org/doi/10.1126/...

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

Postdoc Research Group Schur The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ...

We're hiring a postdoc!
Join our ActinID project to explore an uncharacterized actin-binding protein.

- Background in cell and/or structural biology?
- Eager to bridge both fields?

Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin

ista.ac.at/en/job/postd...

Check our recent works for near-atomic resolution structure of ANDV tetramers by cryoEM!

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design pubmed.ncbi.nlm.nih.gov/40463071/ #cryoEM

If anyone is at #RNA2025, please stop by my lab’s posters on triphosphate balance and virus infection and tracking persistent infection with precision to identify viral miRNA functions.

Authors Szymanik and Mojumder are really great and are presenting in the second session this Friday from 8-10.

Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen www.biorxiv.org/content/10.1101/2025.05.19.654955v1 #cryoEM

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...

Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC.

www.biorxiv.org/content/10.1...

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

A compact viral IRES translates a downstream open reading frame www.biorxiv.org/content/10.1101/2025.05.13.653779v1 #cryoEM

SoftAlign: End-to-end protein structures alignment https://www.biorxiv.org/content/10.1101/2025.05.09.653096v1

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software!
Hope it will be useful !

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

The executive targets his opponents w/bogus investigations. His government disappears people w/out due process and vanishes them beyond reach. He usurps legislative power, controls public funds at will, & consolidates power. Loyalty is expected — or else.

Authoritarianism isn’t coming. It’s here.

The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture A multi-protein system called the divisome promotes bacterial division. This apparatus synthesizes the peptidoglycan (PG) cell wall layer that forms the daughter cell poles and protects them from osmo...

It has been coming a long way... happy to share our latest work with you: www.biorxiv.org/content/10.1...
Here, we show the importance of septal fortification by the Class A Penicillin Binding Protein, PBP1b, in E. coli and provide a molecular mechanism for this function. (1/12).

Structural basis for neutralizing antibody binding to pertussis toxin pubmed.ncbi.nlm.nih.gov/40172968/ #cryoEM

Repost appreciated:

Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.

Deadline 4 May. More info: www.carlsonlab.se/join/

Those trying to understand the tariffs as economic policy are dangerously naive.

No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.

1/ A 🧵 to explain his plan and how we fight back.

From: owner-nih-all-staff@list.nih.gov <owner-nih-all-staff@list.nih.gov> on behalf of NIH Executive Secretariat <NIHExecSec@nih.gov> Sent: Tuesday, April 1, 2025 9:44 AM To: List NIH-ALL-STAFF <NIH-ALL-STAFF@LIST.NIH.GOV> Subject: From the NIH Director: Honored to Lead NIH Dear Colleagues: As I begin my tenure as the 1gth Director of the National Institutes of Health, I want to first express my appreciation for all of you — the NIH scientists and staff whose work has contributed to lifesaving breakthroughs in biology and medicine. I most recently worked at Stanford University where my research in health economics was made possible with NIH support. I am honored and humbled to lead this agency and join you in service of the American people. As a doctor, economist, and (now now former professor at stanto Unersity, I have always been driven by a passion for improving public health and fostering an environment where scientific inquiry can flourish. Throughout my career, I have been supported by NIH, an institution that I love. False: he has degraded scientific inquiry, pushing a pro-billionaire privatization agenda. NIH's mission to enhance health remains vital as millions of children and adults in this country face poor outcomes due to chronic diseases like obesity, heart disease, and cancer. We must build on the agency's track record of tackling complex challenges and recommit to our mission to addressing the chronic disease crisis. While basic research will continue to lay the groundwork for future discoveries, we will invest in innovative, cutting-edge research that has the power to transform health. Importantly, our discoveries will only make an impact if the public has confidence in our findings and trusts that we are working in their best interests. To help us achieve these goals, I have Establared it tonomig is lo prones, ignore real science/medicine 1. Focus on Improving Population Health: The work of NIH, whether basic or applied, must address the health need…

Jay Bhattacharya just sent a letter to all NIH staff, amidst the Musk/Trump chaos, and we have it for you!

We unpack Bhattacharya's 'anti-vax grifterese' (h/t @angierasmussen.bsky.social ) and point out what he is really saying.

You'll want to click and zoom in on this one.

Post-doc position is available in Choi laboratory at IU. Our research focuses on the structure and function of viral RNAs & replication. Experience in biochemistry or structural biology (X-ray crystallography & cryoEM) is required. Please send cover letter and CV to kaychoi@iu.edu

Please repost.

Well done Columbia leadership and Paul Weiss...

Official Website of the Department of Homeland Security SEPARTMEN U.s. OF U.S. Immigration and Customs Enforcement Main Menu Search Results: 1 RUMEYSA OZTURK Country of Birth : Turkey Status : In ICE Custody State: LA Current Detention Facility: SOUTH LOUISIANA ICE PROCESSING CENTER * Click on the Detention Facility name to obtain facility contact information

So Rumeysa Ozturk is arrested in MA on Tuesday. Her lawyers rush to federal court on Tuesday night and obtain an order—ON TUESDAY NIGHT—not to move her out of MA. All day yesterday, ICE won’t say where she is. And now, on Thursday, they say she’s in Louisiana.