Scott Rush

A broadly protective antibody targeting gammaherpesvirus gB pubmed.ncbi.nlm.nih.gov/41629701/ #cryoEM

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)

🔗 biorxiv.org/content/10.6...

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens www.biorxiv.org/content/10.64898/2026.01.26.701809v1 #cryoEM

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

www.nature.com/articles/s42...

@wrapplab.bsky.social

I am pleased to share our new paper in Molecular Cell:

“Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6.”

We visualized, in structural detail, how a double-stranded RNA virus switches from a quiescent to a transcriptionally active state.

Link in the comments

YouTube video by Alice Ting Alice Ting Rosettacon keynote 2025

Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states

CB part starts at 14:55

Thanks to Peter Cavanagh and Andrew Xue – amazing graduate students who co-led this work

Computational design of conformation-biasing mutations to alter protein functions Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Can we design mutations that bias proteins towards desired conformational states?

Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen pubmed.ncbi.nlm.nih.gov/41484092/ #cryoEM

Structural basis for childhood antibody recognition of the human metapneumovirus fusion protein pubmed.ncbi.nlm.nih.gov/41455691/ #cryoEM

De novo design of protein nanoparticles with integrated functional motifs https://www.biorxiv.org/content/10.64898/2025.12.19.695620v1

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Generation of antigen-specific paired-chain antibodies using large language models MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addresses traditional limitations by enabling efficient, target-agnostic antibody design with experimentally validated binding specificity.

Now online! Generation of antigen-specific paired-chain antibodies using large language models

Our new preprint is out 🥳🥳🥳

Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?

👇

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1

Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz

Antibodies blocking PlGF or VEGF interactions with the NRP1 receptormediate anti-proliferative effects https://www.biorxiv.org/content/10.1101/2025.10.25.684565v1

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

Tenure-based Research Staff Scientist Position in Computational Structural Biology ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...

ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!

Please spread the word!

ista.ac.at/en/job/tenur...

Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity The Pfs230:Pfs48/45 complex is the target of leading anti-malaria transmission-blocking vaccine candidates, yet its molecular assembly is poorly understood. Bekkering, Yoo, Hailemariam, et al. determined the cryo-electron microscopy structure of the endogenous Pfs230:Pfs48/45 complex bound to six potent transmission-blocking antibodies, providing a structural basis for antibody inhibition and blueprints for the design of next-generation malaria vaccines.

Online now: Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!

Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.

Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

Structural Basis for Childhood Antibody Recognition of The Human Metapneumovirus Fusion Protein https://www.biorxiv.org/content/10.1101/2025.08.29.673069v1

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...

🚨 New paper alert! 🚨

Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

Predicting the translation efficiency of messenger RNA in mammalian cells Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:

Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l