New article on @biorxiv-immuno.bsky.social: our study on a first-in-class family of #NLRP3 inhibitors: CNS-penetrating indazole scaffolds! #BAL-compounds

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins https://www.biorxiv.org/content/10.1101/2025.05.11.652819v1

Degrading the key component of the inflammasome: development of an NLRP3 PROTAC This study explores PROTACs for NLRP3, the key player in innate immunity. We utilised a thiophene analogue of the NLRP3 inhibitor MCC950 and employed CuAAC chemistry for the assembly of PROTACs bearin...

New paper out on Chemical Communications:
"Degrading the key component of the inflammasome: development of an NLRP3 PROTAC"
doi.org/10.1039/D4CC...

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action https://www.biorxiv.org/content/10.1101/2024.12.21.629867v1