Gregor Hagelueken

Excellence Strategy Funds Bonn Cluster for Immune Research The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…

Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉

www.immunosensation.de/news/immunos...

A collage with symbolic images of all eight clusters of excellence. A man working on a machine, an observatory, two people in a field, a woman writing something on a piece of paper, a woman in front of a device, a man writing something on a blackboard, an exhibition, a woman looking through a telescope.

A landmark success! The University of Bonn secured funding for all six existing Clusters of Excellence and both new initiatives – more than any other German university. More: www.uni-bonn.de/en/news/095-...

© G. Hübl, V. Lannert, M. Thürbach/ECONtribute, J. F. Saba/UKB, S. Wegener/ML4Q; N. Wietrich

Thanks to @biancabroske.bsky.social , @scbinder.bsky.social , @tim-kempchen.bsky.social and all the other authors for a fantastic collaboration. A big thank you goes to the developers of #RFdiffusion, #Chroma, #Bindcraft and others to make these amazing algorithms available.

We created a number of high affinitiy and highly specific #AI-Binders against several cancer surface proteins and converted them into easy to use #FACS reagents that we termed #Quattrobinders.

In close collaboration with the @mholzel-lab.bsky.social and @jsb-lab.bsky.social labs, we setup a scaleable AI-Binder design and validation pipeline.

When we saw the first tweats about #RFdiffusion and #Chroma, we wanted to try if we can apply these tools to our own research.
Have a look at our preprint and learn what worked out of the box and what didn't.

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...

Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

Please also check out another exciting work on AI-based protein design, which was a fantastic team effort with Michael Hölzel, @gha14.bsky.social, Tobias Bald and many colleagues at @unibonn.bsky.social
www.biorxiv.org/content/10.1...

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria

We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase

Congrats Francois Rousset, Ilya Osterman and coauthors!

www.science.org/doi/10.1126/...

A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...

www.nature.com/articles/s41...

Neutrino Modem xkcd.com/3017

Well done, Philipp!

Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays.
Way to go Jimbo!

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein - Communications Biology Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

We identified a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP.
Thanks to the team including: @philipphendricks.bsky.social @scbinder.bsky.social @gavinhthomas.bsky.social @gha14.bsky.social
Read the full story here:

doi.org/10.1038/s420...

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP.
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀

@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...

Really happy to share our latest work in its final form in @jgenphysiol.bsky.social on the characterisation of a TAXI TRAP binding protein from V. cholerae.
shorturl.at/88tdH

This work was led by SoCoBio DTP student Joe Davies (not on Bluesky yet) and was really fun to work on.

Identification of a staphylococcal dipeptidase involved in the production of human body odor The production of human body odor is the result of the action of commensal skin bacteria, including Staphylococcus hominis, acting to biotransform odorless apocrine gland secretions into volatile chem...

Newest paper from the Reyme Herman on a Staphylococcal peptidase which we found is involved in the production of thioalcohol-based body odour in human. Continuing our long collaboration with Unilever www.jbc.org/article/S002...

If you work on bacterial immune systems, this founding paper by Burroughs and Aravind is a must-read (and must-cite). pubmed.ncbi.nlm.nih.gov/32868406/

This is the first fully open source release of a AF3 like model. Awesome! Congratulations to the team.

Important paper - just imagining the possibilities if bacteria sense phage infection in neighbours

Structural unification of diverse membrane-bound acyltransferases reveals a conserved fold that defines the Transmembrane Acyl Transferase (TmAT) superfamily The movement of acyl groups across biological membranes is essential for many cellular processes. One major family of proteins catalysing this reaction are the acyl transferase family 3 (AT3) proteins...

New paper from the lab, expanding our work on bacterial AT3's using DALI/FoldSeek to provide the first solid structural evidence to support a Transmembrane Acyl Transferase (TmAT) superfamily of membrane-bound enzymes in all three domains of life.
www.biorxiv.org/content/10.1...

Yesterday my student Niels Schneberger successfully defended his PhD thesis! Congratulations Niels and thanks for everything. What a journey!