ComplexPortal

🌉By integrating QSProteome, the Complex Portal bridges experiment-based curation & computational prediction, empowering exploration of alternative structural data.

📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab

🔗 References are available for 4,000 manually curated and 12,960 predicted complexes, with
🧊 interactive 3D models,
📊 quality metrics (pLDDT, ipTM, PAE),
🧾 functional annotations, and 🛠️ community curation.

🎉 Update from the Complex Portal!

🧬 The Complex Portal now links to QSProteome, a community-driven resource for predicted protein complex structures.

👏 Thanks to our collaborators and the Complex Portal community!

🔗 Explore: www.ebi.ac.uk/complexporta...

#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊

🎉 Complex Portal release 252 is out! 🎉

5,296 manually curated biological complexes are now live, in sync with UniProt 2026_01 🚀

Highlights by species:
🧬 Homo sapiens – 2,499
🌱 Arabidopsis thaliana – 228
🧫 Saccharomyces cerevisiae – 634
🧬 Schizosaccharomyces pombe – 145

Complex Portal release 252 is out! 5,296 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2026_01)

Are you working on challenging projects in structural biology?

#EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬

s.embl.org/mmo26-01-bl

👩‍🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨

#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026

Explore key blood & circulation complexes:

1. 🩸 Haemoglobin
🔗 tinyurl.com/3rdhwk3h
2. 🧴 Cholesterol homeostasis
🔗 tinyurl.com/23hvtnzx
3. 🧪 Prothrombinase (coagulation)
🔗 tinyurl.com/34m7f5e7
4. 🛡 Complement C3/C5 convertases
🔗 tinyurl.com/mujtd345

At the Complex Portal, we curate assemblies from haemoglobin complexes (CPX-2158, CPX-2159, CPX-2160) that carry oxygen, to complexes regulating coagulation (CPX-6221), cholesterol homeostasis (CPX-632), and immune clearance - all essential for healthy circulation.

🧬 New Year, new health goals - let’s get real: exercise fads, diets & oxygen therapies promise “blood cleansing,” but oxygen transport, circulation, cholesterol, and immune defence rely on real macromolecular complexes, not detox trends.

#ComplexPortal #EMBLEBI #PlantScience #Ecology #UKCEH #Ammonia #Transporterproteins

🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species

💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.

🌱 Balancing Act: Plants & Ammonium

Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.

💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.

#ComplexPortal #EMBLEBI #PlantScience #Ecology #UKCEH #Ammonia #Transporterproteins

🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species

💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.

This protects plants from ammonium toxicity and shapes species fitness across different nitrogen environments.
Learn more via the Complex Portal: tinyurl.com/yn9zzfav

🌱 Balancing Act: Plants & Ammonium

Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.

💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.

Registration is free but essential: tinyurl.com/4v3jf4e9

Speakers: Susie H. and Eliot Ragueneau

#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

Would you like to learn more about molecular interactions and how to explore them across organisms?

Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

Sandra Orchard: what I’ve learned EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:

“AI is showing how vital data curation really is.”

www.ebi.ac.uk/about/news/p...

🖥️🧬

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:

UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social

#ComplexPortal #PDBe #StructuralBiology #Bioinformatics #ProteinComplexes #LifeSciencesData #EMBL

Follow the link to uncover:

🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).

PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.

#ComplexPortal #PDBe #StructuralBiology #Bioinformatics #ProteinComplexes #LifeSciencesData #EMBL

Follow the link to uncover:

🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).

PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.

🔬 Noticed the new look PDBe?

The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin

🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)

#IntActEBI #Interactome #EMBL

Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable.
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters

📥 Submit your data here:
🔹 IntAct: tinyurl.com/zzrcx742