Clément Cochain

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome Key PointsNK-cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.Decreased circulating NK cells were indep

P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...

Inhibition of integrin alpha V reduces inflammation and the transition to heart failure after pressure overload Integrin alpha V (CD51) is a surface receptor that binds to extracellular matrix ligands and contributes to fibrotic responses, including post-infarct…

Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...

Mouse and human macrophages and their roles in cardiovascular health and disease - Nature Cardiovascular Research Gallerand et al. review the main human and murine macrophage populations, highlighting their phenotypic and functional diversity and how they contribute to cardiovascular health by regulating the infl...

Mouse and human macrophages and their roles in cardiovascular health and disease

Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph

Nature Cardiovascular Research (2024)

www.nature.com/articles/s44...

Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab.
tinyurl.com/ymkvk7vn

We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development in a collaborative environment #WürzburgPlateletGroup #Phosphorylation #PhDPosition
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...

Lots of interesting findings in this new paper, including atherosclerotic plaque stabilization induced by the TREM2 agonist antibody 4D9 in a mouse model of atherosclerosis aggravated by clonal hematopoiesis
www.jci.org/articles/vie...

Excited to share our study on spatio-temporal reconstruction of cardiac scar formation led by Andy Chan. We combine scRNA-seq with spatial transcriptomics to resolve the fibrotic niche and the niche of dedifferentiating cardiomyocytes.
www.biorxiv.org/content/10.1...