Andy Chan 🇭🇰🇦🇺

We also built an Shinyapp interface that allows everyone to access our single cell and spatial datasets easily:
www.wuesi.medizin.uni-wuerzburg.de/cardiac_spat...
We envision our datasets will serve as a resource will provide insights for the cardiac and regeneration/fibrosis fields in the future!

Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...

Huge thanks to my PI Dominic @dominicgrun.bsky.social , my friends/colleagues in the lab, and all my collaborators who shared their efforts and dedication over these years!! This 5 year-journey wouldn’t have been successful
without you all! 🙏
Link of the paper:
www.nature.com/articles/s44...

We built a single-cell & spatial transcriptomic atlas revealing how immune, fibroblasts, and cardiomyocytes coordinate during heart tissue repair, uncovering key crosstalk mechanisms that fine-tune fibrosis, and discovering a rare regenerative mechanism, existing in the adult fibrotic hearts.

Excited to share our new paper “Spatiotemporal dynamics of the cardioimmune niche during lesion repair” just published in Nature Cardiovascular Research!

Huge thanks to my PI Dominic @dominicgrun.bsky.social , my friends/colleagues in the lab, and all my collaborators who shared their efforts and dedication over these years!! This 5 year-journey wouldn’t have been successful
without you all! 🙏

We built a single-cell & spatial transcriptomic atlas revealing how immune, fibroblasts, and cardiomyocytes coordinate during heart tissue repair, uncovering key crosstalk mechanisms that fine-tune fibrosis, and discovering a rare regenerative mechanism, existing in the adult fibrotic hearts.

Thanks Dominic, for all the support and guidance throughout these years ;) I learnt a lot in this journey!

Apple snails can regrow their eyeballs Even without this genetic superpower, human eyes and genes are very similar.

Apple snails can regrow their eyes & @popsci.com is talking about it.

#Research published in @natcomms.nature.com from the @planaria1.bsky.social and @accorsi-alice.bsky.social Labs reveals how these snails rebuild complex, camera-like eyes after injury.

📰 Read the feature: bit.ly/45kXdIn

New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...

Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social

Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. www.nature.com/articles/s41...

Molecular basis of positional memory in limb regeneration - Nature A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.

Nature research paper: Molecular basis of positional memory in limb regeneration

https://go.nature.com/44OtQj3

This is figure 2, which shows the skull of Jinchuanloong niedu in the left lateral view.

A paper in Scientific Reports describes a partial skeleton collected from the Middle Jurassic Xinhe Formation of Gansu Province in China that represents a new taxon of non-neosauropod eusauropods and was named Jinchuanloong niedu. go.nature.com/4jmLXQV #Paleosky 🧪

Are groundbreaking science discoveries becoming harder to find? Researchers are arguing over whether ‘disruptive’ or ‘novel’ science is waning – and how to remedy the problem.

A feature in Nature examines the debate among researchers over whether ‘disruptive’ or ‘novel’ science is waning and how to remedy the problem. 🧪