Vinod Scaria

It was a pleasure speaking on #Pharmacogenomics at the #PrecisionMedicine symposium at AIG Hospitals, Hyderabad

#genomics #wholegenomesequencing #precisionmedicine

Memories from the session in September on Converging Genetics - What , Why and When of #WholeGenomeSequencing at Galle Medical College organised by Galle Medical Association.
Thanks Dr. Lahiru Prabodha for the invitation and the memorable event.

Preparedness is not about predicting the future, but being ready for it in every form.

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Read the latest Editorial published in TCRT
@tcrtcancer.bsky.social - The Bharat Cancer Genome Atlas: Charting India's Unique Cancer Landscape for Precision Oncology
journals.sagepub.com/doi/10.1177/...

@vinodscaria.bsky.social @karkinoshealth.bsky.social

#CancerGenomics #PrecisionOncology

Yesterday, I had the pleasure of taking a workshop on Clinical Genomics and Genetic Variant Interpretation, empowering clinicians and residents with the latest genomics insights.
It is indeed exciting times for genomics in healthcare #GenomicsInMedicine #midtermPHOCON2025

Making A Case for Genomic Newborn Screening in India Almost 1 in 250 children born each year in India has a treatable genetic disease. Genetic screening at birth is nonexistent in public healthcare system

A Healthier Start: Making A Case for Genomic Newborn Screening in India
sciencechronicle.in/2025/07/14/a...

A genomic view of DNA damage in chemotherapy Seventeen of 23 individuals exposed to chemotherapy had far more genetic mutations than could be explained by normal aging. Even more revealing was the discovery of eight unique mutational signatur…

Researchers at Sanger Institute in the UK have used genomic tools to unravel the chemotherapy mutograph in hematopoietic stem cells

Read the complete article at sciencechronicle.in/2025/07/08/a...

Chemotherapy is a double edged sword and while effective against a number of cancers, and often the first line of therapy in many, can cause significant genetic mutations in healthy cells, and sometimes increased risk of new cancers over a long time.
1/2

Whole-genome sequencing of 2,762 Indians has unravelled the layers of ancestry, high intermixing with Neanderthals and Denisovans. This along with high endogamy in India could potentially result in harmful mutations in some groups.

share.google/EzZEcHF47IdT...

Association of Pathogenic/Likely Pathogenic Genetic Variants for Cardiomyopathies With Clinical Outcomes: A Multiancestry Analysis in the All of Us Research Program | Circulation: Genomic and Precisio... BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcom...

Carriers face a significantly higher risk (2-4x) of heart failure, cardiomyopathy, and arrhythmias.

This underscores the potential of genetic screening for early detection and intervention.
www.ahajournals.org/doi/10.1161/...

💔 New research from the All of Us Program reveals that 1.2% of South Asians carry key cardiomyopathy gene variants and this is almost 50% more than the frequency in people with European or African ancestry and more than double the frequency in people with East Asian ancestry

Hi. Would you be able to share a preprint or PDF at drvinod(at)gmail.thanks in advance.

It is time for Genomics in Chronic Kidney Disease

Kerala Literature Festival discussion on #Genomics for People of #Kerala

#klf #klf2025 #keralalitfest

A man in his 20s has died from a highly pathogenic avian influenza (H5N1) infection in Cambodia.Acco.. - MK A man in his 20s has died from a highly pathogenic avian influenza (H5N1) infection in Cambodia.According to local media Khmer Times and Xinhua News Agency on the 11th, a 28-year-old man died the prev...

🔴 According to news sources, a man in his 20s has died from a highly pathogenic avian influenza #H5N1 infection in #Cambodia
www.mk.co.kr/en/world/112...

I would be speaking at the 12th Annual Conference of the Molecular Pathology Association of India (#MPAICON2025) mpaicon2025.com

A newly discovered human pneumovirus isolated from young children with respiratory tract disease - PubMed From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene ...

The virus was first isolated in Netherlands in 2001 children with respiratory tract infections. Serological studies by the authors suggested that by the age of 5 years, virtually all children in the Netherlands have been exposed to human metapneumovirus.
pubmed.ncbi.nlm.nih.gov/11385510/

Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children | NEJM We sought to determine the role of human metapneumovirus in lower respiratory tract illness in previously healthy infants and children. We tested nasal-wash specimens, obtained over a 25-year perio...

In fact hMPV is quite prevalent with estimates of almost 1 in 10 of all lower respiratory tract infections in the US

www.nejm.org/doi/full/10....

The severity of the disease is similar to that of RSV. Severe disease is seen in children as well as elderly, apart from individuals with compromised immunity

hMPV shows a seasonal pattern, with the peak infections during winter.

Short answer first : No

Follow the rest of the thread only if you would like to know more and understand in detail.

Human Metapneumovirus (hMPV) is not a new virus. It was first isolated in 2001 and a very prevalent viruscausinh mild infections, usually similar to the common cold or flu

🔴 hMPV outbreak in China.
Should we be worried?
A short 🧵 explaining

Thanks . Feeling is mutual

The details on the genome sequences are at the CDC release here

www.cdc.gov/bird-flu/spo...

CDC says H5N1 bird flu sample shows mutations that may help the virus bind to cells in the upper airways of people The CDC said Thursday that the mutations, detected in a sample taken from a Louisiana patient, may help bind the virus to the upper airways in people.

Read the post by @helenbranswell.bsky.social www.statnews.com/2024/12/26/c...

🔴 Evolution - one step at a time . Genetic sequences of #H5N1 #birdflu viruses collected from a person in Louisiana who became severely ill show signs of development of several mutations thought to affect the virus’ ability to attach to cells in the upper airways of humans.

Did you know ?
Genomic testing in a large cohort of patients with Cerebral Palsy indicate that actionable genetic findings occurred in 8% of individuals and pathogenic variants in 27%. jamanetwork.com/journals/jam...