Lara Muffley

“THE ONLY THING MORE POWERFUL THAN HATE IS LOVE.”

Let’s go Hawks!! 🏈

Our @varianteffect.bsky.social annual reports summarize, celebrate and showcase our collective work.
Read the latest 🔖 zenodo.org/records/1833...
View them all 📖 www.varianteffect.org/annual-repor... #AnnualReport #GlobalAlliance
#FunctionalGenomics #Consortium

A recent preprint introduces MaveMD, a clinical interface for MaveDB that integrates MAVE data with ClinVar and ClinGen to support variant classification and reduce VUS uncertainty.

Uncover the science behind it:  www.medrxiv.org/content/10.1...

We’re happy to share our 2025 Annual Report!
A year of "momentum and connections"!
➡️ zenodo.org/records/1833...
#AnnualReport #GlobalAlliance #FunctionalGenomics #VariantEffect #Community

Recommended reading!

The recording is now available www.youtube.com/watch?v=domr...

We have a special event coming up in early January.
Learn more and Save the Date!
ℹ️ www.varianteffect.org/event/firesi...

Happening now!
Zoom link here: www.varianteffect.org/seminar-seri...

Today is the deadline to submit your abstract.

Did you know that we have a Variant Effects Seminar Series playlist on YouTube? Tune in to watch previously recorded talks at your leisure 📺☕ www.youtube.com/playlist?lis... #FunctionalGenomics #Seminar

Tomorrow!
www.varianteffect.org/seminar-seri...

MSS26 - Abstract submission This form will enable you to submit an abstract for consideration for presentation at the 2026 Mutational Scanning Symposium & Workshop (MSS26). MSS26 will be held at the Aikenhead Centre for Medical ...

The FINAL Deadline to submit your #VariantEffect26
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...

Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org

So looking forward to this meeting!

Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org

#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org

Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.

🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!

The image is a promotional graphic for a "Fireside Chat" event organized by the Variant Effects Seminar Series and the AVE Alliance. The background is light gray, and the text is in dark gray and green. At the top, there is a stylized image of a fireplace with flames. Below, bold text reads "Fireside Chat," with an invitation to join on January 6th, 2026, featuring Dr. Maitreya Dunham and Dr. Matthew Hurles discussing MAVEs in clinical space and model organism systems. The date and time are highlighted in dark and light green ovals: "01.06.26" and "9:00AM (Pacific)." To the right, the Atlas of Variant Effects logo is displayed featuring stylized DNA strands formed by interwoven lines. At the bottom, there are two photos: on the left is Dr. Maitreya Dunham, with the text "Maitreya Dunham, University of Washington," and on the right is Dr. Matthew Hurles, with the text "Matthew Hurles, Wellcome Sanger Institute."

Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)

Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar

Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social

🦕🦖🦕🦖🦕🦖 Conference dinner at Melbourne Museum ! Yes please.

🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org

We have an incredible speaker line-up for next years Mutational Scanning Symposium 🤩. Register now and submit your abstract before the deadline next week!
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline

brotmanbaty.org/news/q-and-a... @brotmanbaty.bsky.social Q&A with #VariantEffect26 co-organizer Rehan Villani.

Want to be our colleague? We have a faculty position in microbial systems biology looking for candidates. Please share. www.rh.ulaval.ca/emplois-disp...

Variant Effects Seminar Series
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/

This role, based at Sanger, will lead on the communications for the Atlas of Variant Effects Alliance - an initiative that is mapping the effects of all the possible variants of human genes 🧬

This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...

I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!

@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!