Our faculty search is now live at National Jewish Health. We are recruiting all ranks - strong startup packages and great colleagues! ‪@radoshevichlab.bsky.social‬

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Congratulations to newly minted PhD Dr. Meghan O'Keefe on an outstanding dissertation defense today! @cwrumstp @meokeefe.bsky.social

This leads to the obvious hypothesis that this signaling axis helps inflammasome activation couple innate-to-adaptive immune coupling by regulating amplitude and duration of cytokine release. Many congrats to Meghan for this 20-page opus! 4/n

Upon ERK1/2 inactivation, the mRNA stability protein TTP becomes dephosphorylated and unstable. This causes mRNA half life to be increased and causes multiple cytokines and chemokines to be released at high level.s 3/n

In this work, Meghan found that inflammasome agonist exposure rapidly caused inactivation of ERK1/2. This inactivation was due to mitochondrial disruption causing activation of the dual specificity phosphatase DUSP6. 2/n

Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP O’Keefe et al. determined that inflammasome agonists, working through the mitochondria, rapidly inactivate ERK1/2. They further show that the ERK substrate, TTP, is also inactivated, leading to increa...

We are excited to share a new paper from the lab - led by first author and @cwrumstp @cwrusom student Meghan O'Keefe. 1/n

Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports www.cell.com/cell-reports...

How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot Cryo-EM structures of ninjurin-1 and ninjurin-2 explain how their distinct geometry as oligomeric filaments relates to their differing capacity to solubilize the plasma membrane during inflammatory ce...

Congrats to colleagues George Dubyak and Xinghong Dai on this groundbreaking work showing NINJ1 and 2's roles in membrane integrity. A great collaboration that started after a departmental seminar!

How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot: Cell www.cell.com/cell/fulltex...

Derek Abbott, MD, PhD, Named Cecil and Ida Green Following a national search, National Jewish Health named Derek Abbott, MD, PhD, the Cecil and Ida Green Chair of the Department of Immunology and Genomic Medicine. Dr. Abbott is currently the Arline ...

I'm very humbled and excited to announce a career change come summertime. Thanks to all at Case Western for a wonderful and productive 18+ years.

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