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Cell Regeneration, a fully Open Access journal officially affiliated with the Chinese Society for Cell Biology, covers research on stem cell biology, regenerative biology, and related clinical translation.
Frizzled-related Protein modulates mitochondrial function via the Wnt/β-catenin signaling pathway
Cell Regen Research | Frizzled-related protein (FRZB) protects periodontal ligament stem cells from inflammation-induced osteogenic defects!🦷 While inflammation downregulates FRZB and impairs osteogenesis, overexpression restores. #Periodontitis #StemCells
🔗https://doi.org/10.1186/s13619-026-00283-z
MORF4-related gene on chromosome 15 (MRG15) interacts with MyoD to regulate histone acetylation and transcription of myogenic genes
Cell Regen Research | Even spaceflight-like aging reveals MRG15 as a key player 🧩 in muscle stem cell regeneration! Its decline in aged/injured MuSCs impairs regeneration via MyoD disruption & histone changes.
#MuscleRegeneration #StemCells
🔗 Full paper at: doi.org/10.1186/s136...
Extracellular vesicles derived from neonatal mouse skeletal muscle accelerate muscle regeneration and reduce adipocyte infiltration and collagen deposition in vivo
Cell Regen Research | Speed up muscle repair! 🩹 Neonatal muscle extracellular vesicles activate satellite cells, boost regeneration, and reduce fibrosis/fat infiltration in glycerol injury models. #MuscleRegeneration #StemCells
🔗 Full paper at: doi.org/10.1186/s136...
DTR-mediated endothelial cell ablation after DT administration. A) Immunostaining for GFP, DTR, and DAPI on liver, heart, and lung sections from Cdh5-DTRGFP mice. B) A schematic showing experimental design. One pulse of PBS/DT was injected at 6 weeks, and mice were sacrificed after 2 days. C) Survival of DT treatment- and ctrl-mice. D) Bright field of the liver from DT-induced and ctrl mice. E) Immunostaining for GFP on livers from PBS- and DT-treated mice. F) Immunostaining for GFP, VE-cad, Ter119, and DAPI on liver, heart, and lung sections from mice treated with PBS or DT shows a significant leakiness of blood cells (arrowheads) in DT-treated mice. G) Analysis of the Ter119+ erythrocytes in liver, heart, and lung sections per 20×field from different sections. H) Schematic model of DTR-mediated endothelial cell ablation and vascular leakage. Upon binding to its DT, the DTR expressed on endothelial cells triggers specific cell death pathways. This resultant endothelial cell loss disrupts the integrity of the vascular wall, leading to vessel rupture and subsequent extravasation of erythrocytes. Data are means ± SEM. n = 5 mice. The yellow scale bar represents 2000 μm. The white scale bar represents 100 μm.
Cell Regen Research | A new mouse model for precise endothelial cell ablation! 🩸Dual Cre/Dre logic activates DTR for precise vascular studies.
#EndothelialCells #GeneEditing
🔗 Full paper at: doi.org/10.1186/s136...
Long non-coding RNA nonnmmut065573 (tentatively designated LncRNA-IH) activates the TGFβ−1 signaling pathway after myocardial infarction
Cell Regen Research | LncRNA-IH drives cardiac fibrosis after myocardial infarction!🫀🫀
Overexpression worsens remodeling & activates TGF-β1/ZEB1 in fibroblasts. #CardiacFibrosis #HeartFailure
🔗 Full paper at: doi.org/10.1186/s136...
DOI: https://doi.org/10.1186/s13619-025-00261-x
Cell Regen Research | |✨Primed hPSCs → functional trophoblast stem cells in days?🧬
Transient MEK/ERK inhibition + balanced WNT yields stable hTSCs with strong STB/EVT potential. #StemCells #Trophoblast
🔗 Full paper at: doi.org/10.1186/s136...
Take-home figure: CPP drives the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into functionally competent vascular endothelial cells (VECs). Crucially, the long non-coding RNA MEG3 acts as a pivotal regulator within this differentiation pathway.
Cell Regen Research | CPP drives rapid endothelial differentiation of umbilical cord MSCs! 🧬🧬🧬 >90% VEC conversion in 5 days via MEG3 regulation—functional in vitro & in vivo. #StemCells #VascularRegeneration
🔗 Full paper at: doi.org/10.1186/s136...
Exogenous murine MSCs enhance zebrafish fin regeneration
Cell Regen Report | Mammalian MSCs enhance zebrafish fin regeneration! 🐠🐠 MSC-derived PGE2 regulates macrophage recruitment & resolution, boosting repair. #Regeneration #Macrophages #StemCells
🔗 Full paper at: doi.org/10.1186/s136...
Impact of α-KG treatment on skin flaps
Cell Regen Research | α-Ketoglutarate boosts skin flap survival! 🩹 Enhances angiogenesis via PI3K/Akt/HIF-1α in ischemic flaps. #Angiogenesis #WoundHealing
🔗 Full paper at: doi.org/10.1186/s136...
Integrating imaging technologies with single-cell & spatial omics – a new paradigm for developmental biology
Cell Regen Review | Imaging + single-cell omics: a new paradigm in developmental biology! 🔬Super-resolution & light-sheet meet spatial transcriptomics for multi-scale insights. #DevelopmentalBiology #SingleCellOmics
🔗 Full paper at: doi.org/10.1186/s136...
Identification of direct OCT4 targets through integration of OCT4 ChIP-seq and nascent RNA-seq data
Cell Regen Research | 🎯Direct Oct4 targets in ESCs revealed! Auxin-inducible degron (AID) system + nascent RNA-seq uncovers immediate transcriptional changes in pluripotency genes & non-coding RNAs. #StemCells #Pluripotency
🔗 Full paper at: doi.org/10.1186/s136...
The proposed mechanism for maintaining the odontogenic potential in dental mesenchymal cells (DMCs) using the novel N2B27-based culture medium
Cell Regen Report | Major step forward in 🦷 regeneration! New N2B27-based culture medium keeps mouse dental mesenchymal cells odontogenic for 14 days — BMP4 down, OPN/ATRA — enabling regenerative teeth in vivo. #ToothRegeneration #mesenchymalcells
🔗 Full paper at: doi.org/10.1186/s136...
A single-cell journey through the bone marrow vascular niche across life – meet the new player, Midkine!
Cell Regen Research | 🔎Single-cell atlas reveals lifelong evolution of bone marrow vascular niche! From fetal liver to aged BM, Midkine emerges as a new regulator of HSPC reconstitution. #Hematopoiesis #StemCellNiche
🔗 Full paper at: doi.org/10.1186/s136...
Regulation of Poly(A)-tails in stem cell and early development
Cell Regen Review | Poly(A) tails: the hidden switch in stem cell fate & early development! Length dynamics drive mRNA stability & translation. #StemCells #RNAbiology
🔗 Full review at: doi.org/10.1186/s136...
Hypoxic–ischemic preconditioning regulates mitochondrial metabolism
Cell Regen Review | 📝Hypoxic–ischemic preconditioning (H/IPC) protects the 🧠 via mitochondrial metabolism—H/IPC boosts mitophagy, curbs fission & apoptosis for neuroprotection. #Mitochondria #Neuroprotection
🔗 More at: doi.org/10.1186/s136...
p-Enh deletion disrupts NMPs’ bi-potency and biases lineage commitment toward PSM fate across in vitro, in vivo, and in silico models
Cell Regen Research | Posterior enhancer (p-Enh) maintains neuromesodermal progenitor bi-potency during gastrulation! Deletion biases fate toward presomitic mesoderm, thereby disrupting spinal cord development. #StemCells #Embryogenesis
🔗 More at: doi.org/10.1186/s136...
Single cell transcriptomic analysis on six primary human hepatocytes
Cell Regen Report | Validating quality standards for primary human hepatocytes! ✅ Tested viability, markers & metabolism in hepatocytes, revealing heterogeneity for liver studies. #Hepatocytes #CellBiology
🔗 More at: doi.org/10.1186/s136...
Schematic overview of cardiomyocyte regulators orchestrating the dedifferentiation, proliferation, and redifferentiation process
Cell Regen Review | Rewiring cardiomyocyte identity & metabolism for heart regeneration! 🫀 Strategies for improving cardiac function in animal models. #HeartRegeneration #StemCells
🔗 More at: doi.org/10.1186/s136...
DOI: https://doi.org/10.1186/s13619-025-00255-9
Cell Regen Review | Cell Regen Review | Drug-induced beta cell regeneration for diabetes! 🩺 Small molecules & pathways target proliferation to restore insulin production. #Diabetes #StemCells
🔗 More at: doi.org/10.1186/s136...
3D imaging of neural tissues using advanced tissue clearing and Light-sheet microscopy
Cell Regen Review | What tech is advancing central nervous system repair in neural regeneration? 🧠Optogenetics, gene editing, 3D culture, single-cell sequencing, 3D imaging and more… #NeuralRegeneration #StemCells
🔗More at: doi.org/10.1186/s136...
DOI: https://doi.org/10.1186/s13619-025-00259-5
✨Cell Regen Highlight | Transgene-free mouse embryo models via chemical reprogramming reach early organogenesis! Advances in PSC-derived iEFC-EMs & TF-SEMs for development & regen med. #StemCells #EmbryoModels
More at: doi.org/10.1186/s136...
Microglial subpopulation subdivision and functional analysis showing CD44 as a key receptor regulating the inflammatory response
Cell Regen Research | CD44 & Nucleolin regulate gliogenesis after spinal cord injury! scRNA-seq reveals SPP1-CD44 in microglia inflammation & PTN-NCL in astrocyte proliferation. #Inflammation #Gliogenesis
🔗More at: doi.org/10.1186/s136...
Pathways for FGSCs to restore ovarian function (Modified from Servier Medical Art)
Cell Regen Review | FGSCs: Hope for ovarian repair & fertility preservation! 🧬 Recent advances in stem cells for aging/damaged ovaries, with challenges ahead. #StemCells #Fertility 🔗 doi.org/10.1186/s136...
13.08.2025 00:44 — 👍 1 🔁 0 💬 0 📌 0
Schematic of tooth regeneration process
Cell Regen Review | Insights into tooth regeneration! 🦷 Stem cells & scaffolds drive pulp-dentin trials, while enamel repair evolves. #ToothRegeneration #StemCells
🔗Read more: doi.org/10.1186/s136...
XGB-IBD10 achieves a better performance than other top species-based methods
Cell Regen Research | 10-species microbial signature for IBD diagnosis. 🩺 XGBoost model (XGB-IBD10) achieves 87% accuracy!🎯 #IBD #Microbiome
🔗 doi.org/10.1186/s136...
Schwann cells expressing Dox-inducible MANF protect axons and promote regeneration
Cell Regen Research | MANF-modified Schwann cells (SC) boost peripheral nerve repair! 🧠 Enhances axon regeneration & SC dynamics. ✨ #NerveRegeneration #SchwannCells
🔗 doi.org/10.1186/s136...
Characteristics of microbial alpha-diversity and beta-diversity among MICT, HIIT and HIFT
Cell Regen Research | Got a gut feeling? HIFT boosts microbiota diversity & Faecalibacterium for better gut health!💪 #GutMicrobiota #GutHealth #Exercise
📖https://doi.org/10.1186/s13619-025-00244-y
A positive-feedback loop formed by YTHDF2-KIF26B-Wnt signaling maintains the stemness of ISCs
Cell Regen Letter | YTHDF2-KIF26B-Wnt loop drives intestinal stem cell stemness! m6A reader YTHDF2 regulates Wnt signaling, with compensatory mechanisms revealed👇.
📖 doi.org/10.1186/s136...
#StemCells #GutHealth
🎊Latest on Cell Regeneration! We maintain our strong position in Clarivate #JCR2025: IF=4.7!
🔬 Q2 in Cell & Tissue Engineering (Top 31%)
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Grateful to our authors, reviewers & readers! #ImpactFactor #ScienceMetrics #Stemcells
🔗 cellregeneration.springeropen.com
Eerdun-Wurile effectively restores heart function in zebrafish Representative heartbeat fluctuations charts of zebrafish in control
Cell Regen Research | Mongolian medicine Eerdun-Wurile boosts heart regeneration in zebrafish! 🫀 Enhances cardiomyocyte proliferation via MVDA, offering myocardial infarction therapy insights. #Cardiology #Regeneration
🔗 doi.org/10.1186/s136...
