Stem Cell Reports

Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells Gliomas are characterized by extensive intratumoral heterogeneity, recapitulating a hierarchy reminiscent of normal neurodevelopment. This facet is difficult to recapitulate in disease models. Here, W...

Our new study, “Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells,” is online now at @stemcellreports.bsky.social ! Spearheaded by our talented undergrad @danielgao970.bsky.social. A thread on the study: 1/

New study shows distinct #TET enzyme activities guide neural stem cell fate: 5hmC enables neuronal competence, while 5fC and 5caC are essential for #glial lineage. #neurons #stemcells ow.ly/9UX850WygWT

@einsteinmededu.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Hematopoietic #stemcell defects in #Gata2 haploinsufficiency driven by impaired DNA damage response and inflammatory signaling; disrupting self-renewal, differentiation, and genomic stability ow.ly/28kC50WygLf

@cardiffuni.bsky.social @isscr.org

Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...

Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida.

www.cell.com/stem-cell-re...

@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social

New study from @pennmedicine.bsky.social! scRNA-seq of isogenic #iPSC reveal novel individual and cooperative #hematopoietic effects of #trisomy21 and #GATA1. #myelopoiesis #Downsyndrome ow.ly/fpHC50Wrrtm

@childrensphila.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Organoid photo and inspiration for the Cover of @stemcellreports.bsky.social July issue - many thanks to the team that made APOE4's starry night the cover! 🟢 Tuj1 (beta III tubulin for neurons, 🔵 DAPI for DNA 🔴 My favorite protein, APOE

YouTube video by International Society for Stem Cell Research (ISSCR) Stem Cell Reports Submission Tips

Hear from Stem Cell Reports Associate Editor Martin Pera on the 6️⃣ key tips to make your submission process smooth and efficient 👉 youtu.be/xH5OMEvYw2Y
@isscr.org

Recently published: Developmental cues from epicardial cells simultaneously promote cardiomyocyte proliferation and electrochemical maturation #epicardialcells ow.ly/v1LP50WlIC9

@umnpeds.bsky.social
@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Progenitor neighborhoods function as transient niches to sustain olfactory #neurogenesis via Notch/Insm1a signaling. #neuralstemcell #organogenesis #developmentalbiology ow.ly/4KJa50WlHVt

@uabcdib.bsky.social @isscr.org

New review explores the shared origin of #ependymalcells & #neuralstemcells & the potential interplay among different subventricular zone cell populations. Insights into cell fate decisions will inform the therapeutic potential of ependymal cells ow.ly/v5UF50WlHLu @isscr.org

The latest podcast has dropped. Check out Ngan Huang and Soochi Kim talking about their latest publication in stem cell reports, tinyurl.com/yvm35ec7. Listen here tinyurl.com/2njkbp7k or wherever you get your podcasts.

@isscr.org @uclastemcell.bsky.social

New primary breast #organoid research from
@tuftsmedschool.bsky.social published in Stem Cell Reports! DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation. #organogenesis

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

ow.ly/hxl250WlH5o

Large-scale research resource models #Alzheimers disease with high and low polygenic risk in human iPSCs. 100+ lines from patients & controls, a powerful tool to study complex AD biology. ow.ly/TeMO50WlGMv

@ukdri.ac.uk @ox.ac.uk @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New study shows committed hematopoietic progenitor cells proliferate, self-renew, and can initiate myelodysplastic syndrome (MDS) in mice. #MDS #hematology #stemcells ow.ly/gvYu50WlGbX

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

@stemcellreports.bsky.social @isscr.org

Vascular endothelial growth factor-induced vascular permeability results in drastic and reversible hematopoietic stem cell mobilization Smith-Berdan et al. reveal that induced VEGF-induced vascular permeability results in hematopoietic stem cell mobilization from the marrow to the blood at unprecedented levels. This discovery demonstr...

#VEGF overexpression rapidly mobilizes functional #bonemarrow hematopoietic #stemcells to the blood stream and alters bone marrow vascular morphology. VEGF-induced mobilization is reversible bit.ly/3GrTkZH
@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Hard to fully celebrate anything these days with so much happening around the world. Still, I’m grateful for the chance to support our stem cell community @isscr.org ‬as a new early career editor @stemcellreports.bsky.social. Looking forward to receiving your stem cell manuscripts! #stemcells

How an ol'factory' assembly line constantly manufactures neurons: Pleased to share our work in @stemcellreports.bsky.social, led by Sriivatsan G. Rajan in collab w/ L. Nacke, J. Lombardo, K. Wong, E. Somodji, J. Garcia, and the lab of dearly departed Dr. Jie Liang. 1/3 www.cell.com/stem-cell-re...

#ALS research on #neuroinflammation uses a 3D spinal microtissue model of C9orf72 ALS. FDA-approved drug screen IDs #sartans as inhibitors of neuroinflammation, & #telmisartan preserves motoneuron survival against C9-microglia-mediated toxicity. bit.ly/3HYZCQW
@isscr.org

Check out ISSCR's society journal, Stem Cell Reports!

As a member of the early career editorial board for @stemcellreports.bsky.social, I am excited to share that we are looking for submissions in the field of stem cell research! I invite you to submit your work for consideration. invt.io/1bxbuu2o3ek @isscr.org

Check out ISSCR's society journal, Stem Cell Reports!

Excited to join the Stem Cell Reports team as an Early Career Editor! Grateful for the opportunity to contribute to the journal alongside fantastic colleagues. I encourage you to submit your work for consideration! @isscr.org @stemcellreports.bsky.social

New review explores strategies to eliminate tumorigenic hPSCs, evaluates the advantages & limitations of approaches, & discusses various methods that can be used to evaluate efficacy of PSC elimination bit.ly/4k3w6qB
@isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Screenshot from the linked article showing the title, authors, and highlights: "APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids; Karina K. Meyer-Acosta, Eva Diaz-Guerra, Parul Varma, Adyasha Aruk, Sara Mirsadeghi, Aranis Muniz-Perez, Yousef Rafati, Ali Hosseini, Vanesa Nieto-Estevez, Michele Giugliano, Christopher Navara, Jenny Hsieh; Highlights: APOE4 accelerates differentiation and maturation at developmental time points; APOE4 results in a loss of cortical neurons and increase in astrocytes and outer radial glia, APOE4 enhances proliferation, differentiation, and maturation of GABAergic neurons, APOE4 alters GABA-related genes, linked to increased GABA response and synchronicity"

Read the full paper in @stemcellreports.bsky.social : doi.org/10.1016/j.st...

By
@jennyhsieh1.bsky.social
@vanesanieto.bsky.social
@aranismuniz.bsky.social
@mgiugliano.bsky.social
and team

Online now! The #R-spondin 2 (RSPO2)-RNF43/ZNRF3 axis serves as a master regulator for taste tissue homeostasis. bit.ly/4llNA2m

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Online now! Promoting quality standards and reporting best practices to improve quality, reproducibility, and translatability of #stemcell models and results bit.ly/3FX0p4t

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New review exploring how subventricular zone neural #stemcells could aid brain repair in #Parkinsons disease #neurogenesis #celltherapy bit.ly/40p4LIm

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

In the June issue of Stem Cell Reports, Mason, Nie, Coca, and Andrews review evidence that human pluripotent stem cells occupy transient, metastable substates that influence their differentiation outcomes. Read more: cell.com/stem-cell-re...

New study published in Stem Cell Reports from
@mskcancercenter.bsky.social identifies two enhancers essential for regulating #NANOG expression in human embryonic #stemcells ow.ly/JaI450W1bVa

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

New paper analyzes stem cell training programs for US physicians, revealing profit-driven marketing and ties to clinics offering unproven therapies. Highlights red flags for physicians interested in stem cell therapies. ow.ly/mqJW50W1b7Z

@mayoclinic.org @wakeforestmed.bsky.social @isscr.org

Using #neuroectoderm #organoids derived from mouse embryonic #stem cells, this study shows a zinc finger-dependent role for #PRDM13 in regulating retinal progenitor cell fate through #WNT signaling. ow.ly/l5EH50W1a1F
@umich.edu @isscr.org