Chris Shore

In this study, Gallicchio et al. describe how cleavage factor II (CFII) components serve as a mechanistic switch that controls alternative mRNA cleavage and polyadenylation during spermatogenic differentiation.

Learn more here:
➡️ tinyurl.com/gd351649

Adipose tissue gene expression and longitudinal clinical phenotypes are early biomarkers of lipid-regulating drug usage Scientific Reports - Adipose tissue gene expression and longitudinal clinical phenotypes are early biomarkers of lipid-regulating drug usage

Big news! My 1st first-author paper (2 years in making!) reveals adipose tissue gene expression and clinical traits predict future lipid drug use years ahead. Our model hit an impressive AUC of 0.919, dramatically outperforming traditional risk scores (0.722) for prediction! Link below rdcu.be/eDrKr

Trainee Excellence Spotlight: Christopher Shore Trainee Excellence Spotlight, TES, Trainee, Spotlight, ASHG, American Society for Human Genetics, Genetics

Nice to see recent author Christopher Shore featured in the @geneticssociety.bsky.social Trainee Excellence Spotlight!

RNA xkcd.com/3056

I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know

DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states Liu et al. report that DNMT1 inhibition causes transient accumulation of hemi-methylated DNA at CpG islands, which stimulates UHRF1-mediated H3K18ub. This enhances SUV39H1/H2 activity, nucleates new H...

Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants - Scientific Data Scientific Data - Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants

If you're working with Nightingale Health metabolomics data from UK Biobank, be sure to check out the excellent (and important) work @sritchie73.bsky.social and colleagues have done on its QC and normalisation: www.nature.com/articles/s41...

ukbnmr on CRAN: cran.r-project.org/web/packages...

Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh

Single-molecule states link transcription factor binding to gene expression - Nature A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

Interesting to see the discrepancy between different countries here, especially regarding the 'protests about scientific topics' section.

Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex Sleep is an essential, tightly regulated biological function. Sleep is also a homeostatic process, with the need to sleep increasing as a function of being awake. Acute sleep deprivation (SD) increase...

I know I have been hammering down how bad sleep deprivation is for the brain transcriptome, but how much can you undo with a subsequent nap and how fast? Read our preprint and find out www.biorxiv.org/content/10.1...

New preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.