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@sagnera.bsky.social

14 Followers  |  49 Following  |  2 Posts  |  Joined: 05.03.2025  |  1.4874

Latest posts by sagnera.bsky.social on Bluesky

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Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born

authors.elsevier.com/sd/article/S...

17.07.2025 10:07 โ€” ๐Ÿ‘ 48    ๐Ÿ” 23    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"

A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making

Applied to ventral neural tube development

www.biorxiv.org/content/10.1...

29.05.2025 12:08 โ€” ๐Ÿ‘ 133    ๐Ÿ” 51    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 3

This work has been the result of a fantastic collaboration with Artur Kania at IRCM and McGill University and was spearheaded by excellent PhD students Laia Caudet Segarra and Kevin Sangster.

29.05.2025 12:13 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

First preprint from the lab!

Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!

www.biorxiv.org/content/10.1...

29.05.2025 11:56 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify

A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development

A shared molecular timer driving cellular diversity

www.biorxiv.org/cgi/content/...

29.05.2025 06:29 โ€” ๐Ÿ‘ 24    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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