Ian Mellis

Title: Research Assistant
Link for applicants: opportunities.columbia.edu/cw/en-us/job...

Title: Technician B
Link for applicants: opportunities.columbia.edu/cw/en-us/job...

Excited to share a job opportunity to work with me and colleagues at Columbia! If you or someone you know would like to be a Research Technician/Assistant working at the interface of molecular systems biology, virology, immunology, and gene and cell therapies, please reach out! (Links below)

Highly productive and innovative group doing elegant quantitative bio spanning theory, experimental and computational methods, and actual applications. If you're interested in a postdoctoral position studying cancer, development, or single cell biology, reach out to Yogesh!

Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads Background: Genetic mosaicism is a consequence of CRISPR-Cas9 genome editing that is difficult to study, especially when it involves structural variants occurring at low frequency. A comprehensive ana...

New preprint! With PureTarget we achieved >1000× coverage of targets with ~5kb PacBio reads at QV39. This enabled high-resolution analysis of CRISPR-Cas9 outcomes

Key finding: Some CRISPR-mutations may only emerge in the second generation, due to germ cell mosaicism

www.biorxiv.org/content/10.1...

Great case, Naveen! Will definitely keep this in mind

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For SARS-CoV-2, much of the population has been imprinted by a viral spik...

In new study, we find dramatic differences in specificities of serum neutralizing antibodies in infants w single infection by a recent SARS-CoV-2 strain versus adults/children imprinted by an early viral strain.

www.biorxiv.org/content/10.1...

It's an honor to be part of this lecture series to honor Casey's legacy.

Amazing work from @yogogurt.bsky.social lab and Arispe lab on vascular development. Tour de force of quantitative dev bio with thoughtful applications of high-throughput techniques, imaging, stochastic modeling, and more. Congrats to @daniellepi.bsky.social, Jonas, and the team!