Alan Bince Jacob

This model lets us see how indeterminacy allows macroscopic causation and agential control to emerge. Our actions are not fully predetermined but they’re also not caused by specific random events – instead, they are genuinely *up to us*. philarchive.org/rec/POTCCA-6

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c....

And we can see, in creatures that developed nervous systems especially, that they can act *for reasons*, based on the meaning of neural patterns. Living systems literally incorporate knowledge about the world to guide their behavior adaptively. onlinelibrary.wiley.com/doi/10.1111/...

Carefully reading the papers you cite is like a superpower. You might be surprised what you actually find! 😜

Ignoring fluctuations in criterion is problematic: simulations show that criterion fluctuations induce apparent history biases (panel C), lead to underestimated psychometric slopes (panel D) and underestimated measures of sensitivity, such as d' (panel D)

Common neural choice signals reflect accumulated evidence, not confidence! Now out in @cerebralcortex.bsky.social w @helenevanmarcke.bsky.social @pierreledenmat.bsky.social @yfvisser.bsky.social @denizerdil.bsky.social a.o.

Paper: desenderlab.com/wp-content/u... Thread ↓↓↓

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...

I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!

www.biorxiv.org/content/10.1...

So in short….ice baths must be avoided if the goal is muscle building. But, that is not the case for endurance based activities (running, football).

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🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

Ultrasound system for precise neuromodulation of human deep brain circuits - Nature Communications Modulating deep brain structure can lead to therapies for neurological conditions. Here, the authors show a transcranial ultrasound stimulation (TUS) system featuring a 256-element helmet-shaped trans...

Might focused ultrasound one day replace DBS?

UK Scientists built a 256-panel focused ultrasound helmet that can precisely target deep brain regions. Using theta-burst TUS, they stimulated the LGN and found visual cortex activity with effects lasting up to 40 minutes.

#neuroskyence #ultrasound

Honored to be nominated for the 2025 New Scientist Award! 🎉 Excited to see #psychedelic research—and my work on the neural and cognitive effects—gaining more and more recognition in science. I'd be grateful if you can vote for me, using the link below or here: www.newscientist.nl/polls/new-sc...

Good riddance but Sir Jim Ratcliffe and his deputies have made United a joke of a club.

Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in predictive processing, individual differences, and computational modelling of behavioural and neural data? Please apply! #NeuroJobs vacancies.maastrichtuniversity.nl/job/Maastric...

Attractive serial dependence arises during decision-making Our memory of a stimulus can be biased toward or away from previous stimuli, but when this bias arises is unclear. This study shows that attractive serial dependence emerges during decision-making, su...

In #memories, when does bias towards or away from a stimulus arise? New research shows that attractive serial dependence emerges during #decision-making, while repulsive biases originate during early sensory encoding. 🧪
plos.io/3JSztEg

Hmm 🤔

Is it me, or the train moving?
We use vision to maintain balance. Just close your eyes while standing on one leg and you typically feel less stable. But if we use vision, how come we do not fall when looking at a moving visual reference, e.g. a train?
📈🧠🧪
#sensorimotor #balance #BiomechSky

Is It Me or the Train Moving? Humans Resolve Sensory Conflicts with a Nonlinear Feedback Mechanism in Balance Control Humans use multiple sensory systems to estimate body orientation in space. Sensory contributions change depending on context. A predominant concept for the underlying multisensory integration (MSI) is...

Paper was recently featured in J Neuroscience; author copy through OSF.
www.jneurosci.org/content/45/2...
osf.io/emskv/

With sky-less Matthias Albrecht, Markus Gruber, and Robert Peterka. Supported by AFF @uni-konstanz.de

Just over 1 week to go until the application deadline!

Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson's disease Gait dysfunction in Parkinson's disease (PD) is a major source of disability and is often resistant to traditional deep brain stimulation (DBS). Here, we report a novel neuromodulation paradigm, gait-...

Super proud and excited to share our preprint.

www.medrxiv.org/content/10.1...

Sadly, I know a few students who were denied a home upon agreement with just days left before entering into their masters program

Finding a place for shelter is also a concern in Maastricht. There is more competition to secure a home than getting admitted into a research program #opinion

I just want to say this on the #Racism:

Firstly, well done to Antoine Semenyo for, not only reporting the abuse, but also rising above it to deliver *that* performance. #Bournemouth have a proper hero playing for them. Unreal mentality and I hope he receives all the support needed. 🍒

#LIVBOU

Beta burst waveforms in PD! We find that specific types of beta bursts are rate-modulated by l-dopa, and STN-cortical connectivity during these burst types is related to clinical improvement. Fantastic work by Hasnae Agouram with @pierpasorre.bsky.social 🧠📈

See you in Japan! #ISPGR2027

Joris Boulo talking about the affects of an inactive lifestyle on one's daily locomotor ability such as navigating crowds. If you are interested in the VR platform used that included collaboration with @anneheleneolivier.bsky.social, come see us.

Congratulations @chrismccrum.bsky.social on the @ispgr.bsky.social Promising Scientist Award!
#ISPGR2025

First round of symposiums started at #ISPGR2025. Loved the “I am my environment” symposium, exemplifying the power of symposia where the whole is more than the sum of the parts.

Look out today @ispgr.bsky.social #ISPGR2025 for these presentations with members of our group!

In this new preprint, in review @elife.bsky.social, we show what processing steps make up the reaction time using single trial #EEG modelling in a contrast #decision task.

In this 🧵 I'm telling the story behind it as I think it is quite interesting and I can't write it like this in the paper...

Thursday 11:30 at #OHBM2025 - Arjun Ramaswamy from the FIL will give an oral presentation on "Electrophysiological Correlates of Reinforcement Learning in the Human Ventral Tegmental Area", in the Higher Cognitive Functions session. [3/7]