Amit Rai

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude Martí-Mateos et al. show that red blood cells explain improved glucose tolerance at high altitude. By manipulating red blood cell number, they determine that these cells are necessary and sufficient f...

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude

www.cell.com/cell-metabol...

What if cancer immune evasion is driven by metabolites, not mutations?
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com

Chinese Immune Multi-Omics Atlas Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...

CIMA maps cell type–specific regulatory networks by integrating scRNA-seq, scATAC-seq & genetics across 10M+ PBMCs, revealing causal links to immune-mediated diseases.
#SingleCell #Genomics #Immunology #MultiOmics #scRNAseq #scATACseq #HumanGenetics @science.org www.science.org/doi/10.1126/...

The landscape of regulated cell death: It’s all downhill from here The regulated cell death pathways apoptosis, pyroptosis, and necroptosis are connected on multiple levels. To provide a novel and intuitive conceptual framework of the collaborative and complex nature...

Apoptosis, pyroptosis, necroptosis: distinct pathways, shared chaos.
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...

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An expanded registry of candidate cis-regulatory elements - Nature The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

Nature research paper: An expanded registry of candidate cis-regulatory elements

go.nature.com/4pAbARf

Brilliant review by Kory J. Lavine, et al. Single-cell multiomics meets cardioimmunology to reveal immune effector pathways shaping MI, CHD, and AAA.
#CardiovascularImmunology #SingleCell #Omics #HeartResearch @AHAScience @CircRes ahajournals.org/doi/10.1161/CI…

Lysosomes signal through the epigenome to regulate longevity across generations The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

🚨BREAKING: Starving parents in C. elegans pass on longer lifespans to their kids, because apparently hunger is hereditary, but make it epigenetic. "Eat less, live longer—your great-great-grandworms will thank you".@science.org
www.science.org/doi/10.1126/...