Alf Soler-Bistué 🦠🔬🧫

Microbiome: First bacteria we meet can keep us out of hospital For the first time, scientists show how our microbiome forms affects the risk of infection.

Nuestros encuentros tempranos con bacterias son cruciales para el desarrollo de nuestro sistema inmunológico, muestra un estudio británico 👇
www.bbc.com/news/article...

Frontiers | An additional replication origin causes cell cycle specific DNA replication fork speed

Great paper on replication dynamics in E. coli with more than one oriC. What would happen if we further add more oriCs??
frontiersin.org/journals/mic...

Congrats Ole Skovgaad for this sound paper!!

YouTube video by Senado Argentina VALERIA LEVY - COMISIÓN DE CIENCIA Y TECNOLOGÍA 04-06-25

La intervención de @VLeviLab ayer, en el Senado. También im-per-di-ble 👇
www.youtube.com/watch?v=QgTU...

Here is our newest paper recently published in Plant Communications on "Root hair growth under the control of auxin under low temperature low nutrient environment". Comments and suggestions are more than welcome! Here the pdf www.cell.com/plant-commun... Leaded by Victoria Berdion Gabarain et al.

Gene Location Matters Noteworthy — Bacterial genomes are not a laundry list of genes, but dynamic structures intimately connected with cellular function. As a result, natural selection has a heavy hand in shaping chromosom...

schaechter.asmblog.org/schaechter/2...

(sorry for being late with today's 𝘕𝘰𝘵𝘦𝘸𝘰𝘳𝘵𝘩𝘺. we are not "up, up and away" because of ascension day, we simply overslept 🤦‍♂️) #MicroSky

🌱 New manuscript out, with a strong taste of RESISTANCE.
🦠 We genetically improved a commercial soybean inoculant to degrade glyphosate.
🧬 A single mutation boosts stress tolerance & herbicide breakdown.
🌿 Positive impact on productivity & environmental health.
📄 Read it: doi.org/10.1016/j.rh...

😍Un equipo de la UBA se ubicó entre los 5 mejores (de más de 100) en el mundial de “satélites enlatados”👇en la final del proyecto CanSat, organizado por la Universidad Nacional de México, con un satélite del tamaño de una lata que ellos mismos diseñaron y fabricaron 👇

Budget cuts do not curb our enthusiasm! Ian lab meeting today on Bradyrhizobium cell physiology! #LabMeetinDay

Escribime por DM. Si querés ver lo que hacemos visítanos en:
asoler1.wixsite.com/iib-geb

Estas en 3-4° año de biotecnología o carreras afines? Estamos buscando un/a estudiante de @unsamoficial.bsky.social para incorporar al laboratorio y presentar a una beca de entrenamiento de la CIC PBA! Te interesa? Vení a trabajar con nosotros!! #UNSAM #Biotecnologia !!

What a huge story!!! Integrons are page resistance genes carriers!!! Not just silent " long term memory" geneyic structures!! Congrats two all the team!!

Certainly a great place for a posdoctoral experience! Highly recommended!!!

Huge story by @celineloot.bsky.social ! The chromosomal integrons are reservoirs of defense systems against Phages!

Mobile integrons encode phage defense systems Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉

Short 🧵
www.science.org/doi/10.1126/...

Submitted! Fingers crossed!!

📢 III Curso Avanzado en Biología Molecular y Biotecnología Vegetal. 5 - 14 Mayo. Presencial, Universidad de Chile. Estudiantes de pregrado, doctorado, post-doc y técnicos. Clases con investigadores de primer nivel, últimas innovaciones en biotecnología vegetal. Empresas líderes en la industria.

I thank my HUGE collaborators: @amazeld.bsky.social @celineloot.bsky.social @val-meve.bsky.social Briardo Llorente at @pasteur.fr and Macquarie University. The funds and institutions supporting the project @unsamoficial.bsky.social CONICET Agencia I+D+i

Hence, evolution maintains RNAP near oriC highlighting the key role gene order with implications in ecological strategies, adaptation, and synthetic genome design. We provide an experimental framework for investigating how genome architecture shapes cellular function.

The rpoB and rpoC genes are part of a large locus, and being the last ORF of the operon. To show that the phenotypes observed were consequence exclusively of RNA polymerase genes genomic location, we disected the locus.

We then added a second copy of the locus to show that the pheno typic effects are mostly due to alteration in replication associated rpoBC dosage reduction.

We built an rpoC-mCherry translational fusion that allowed us to observe that the distribution is not disturbed upon relocation. However, we notice less RpoC-mCherry protein when the locus is far from oriC.

When rpoBC is far from oriC, growth rate and dosage decreases.

Bacteria harbour a single RNAP encoded by rpoBC genes. In fast-growers it is conserver close to oriC (bsky.app/profile/did:...). We relocated rpoBC (in red) to different locations within Vibrio cholerae genome:

Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria.. The influence of gene order within the chromosome on cellular homeostasis and genome evolution remains unclear. Bacterial chromosomes are structured along the replication origin ( oriC )-terminus ( te...

And its out! Last work of the lab: "Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of
Fast-Growing Bacteria."
We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...

Sin mucho para festejar en el Día Nacional del Investigador Científico. Según la Ley de Financiamiento de la Ciencia, aprobada por unanimidad, este año debía invertirse el 0,45% del PBI. En lugar de eso... 👇

We're about to upload to @biorxivpreprint a preprint on the experimental relocation of RNA Polymerase genes in wich we show the physiological consequences on altering their genomic location. There is a lot to explore in this research theme!

Don't hesitate to contact me for details!

Hoy en la Argentina es el Día del/a investigador/a científico/a por el natalicio de Bernardo Houssay. Houssay fue Premio Nobel de Medicina y fundador del Conicet, del que fue su primer presidente. El Conicet hoy está siendo desmantelado por el gobierno
unr.edu.ar/dia-nacional...

Hard-Wired Control of Bacterial Processes by Chromosomal Gene Location Bacterial processes, such as stress responses and cell differentiation, are controlled at many different levels. While some factors, such as transcriptional regulation, are well appreciated, the impor...

This review summarizes many other (and better) experimental works in where the genomic location of genes is crucial for their function. www.cell.com/trends/micro...