Ishier Raote

✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...

They were fun seminars - I'm glad you enjoyed the session!

They're just runaway domains of the Golgi.

Today at 17:00 CET - the first #MembraneTrafficking seminar of 2026.
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...

Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞

Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social

www.biorxiv.org/content/10.6...

Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -

Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.

Please share🙏:

Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona

Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...

Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

1/9

I thought "corresponding author" meant recognition from the field. I didn’t realise the field was predatory publishing.

I replied “unsubscribe” to a predatory journal email. They thanked me for my interest in submitting.

I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.

www.biorxiv.org/content/10.6...

The Life of Brian seems great - lots of smiling and laughing there. He must have a tendency to always look on the bright side of life.

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

It's out! Our new study (led by @pierrelemerre.bsky.social & @weltgeischt.bsky.social @carlenlab.bsky.social) challenges classical cytoarchitectonic borders in the prefrontal cortex, showing that connectivity better explains its functional organization.
Read the open-access paper here: rdcu.be/eZUkh

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

🥳🥳🥳 Pretty fab start to 2026!!

It's OK! He made it to the bus on time!

Colleague’s PhD paper was repeatedly rejected unless she added a Western blot on mouse 1-cell embryos. After a year of resisting, she gave in and spent months collecting them. Carrying all the embryos to the equipment room, a first-year PhD student running to catch a bus knocked them onto the floor.

The growth of Paris from 250 AD to the present day in 3 minutes.

🔎 CITY 3D TIMELAPSE

We made nanobodies that make your heart🫀 stop 🛑beating. Keep reading to learn how this taught us about how large membrane proteins like ion channels are folded and assembled in human cells. Beyond excited to share my lab's first preprint: Please 🔄 bit.ly/49A0PtD

Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

Asahi Super Dry: helping people through Dry January since 1987.

Exciting preprint from @felixmendu.bsky.social and Yuichi Wakana! A TGN carrier whose budding is driven by ER–Golgi lipid transfer, PKD activity, and a caveolin-based oligomeric coat!
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...

Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)

Fun preprint from @marius-lemberg.bsky.social! TMED9 drives Golgi-bypass secretion of proTGFα via a RHBDL4-independent pathway requiring GRASP65, autophagy machinery and ALIX.
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...

Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...