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Gur Yaari

@guryaari.bsky.social

232 Followers  |  107 Following  |  3 Posts  |  Joined: 25.11.2024  |  1.7009

Latest posts by guryaari.bsky.social on Bluesky

AlignAIR AppHome Immunoglobulin sequence alignment tool

๐Ÿšจ Publication Alert!

AlignAIR is live, a deep learningโ€“powered tool for aligning BCR/TCR sequences:
๐Ÿ‘‰ alignair.ai

Explore the paper for results and methodological details:
๐Ÿ“„ lnkd.in/dKY5fPZz

Itโ€™s been a long, creative, and rewarding journey with an amazing team.

Weโ€™d love to hear your feedback!

17.07.2025 18:27 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...

02.06.2025 01:13 โ€” ๐Ÿ‘ 19    ๐Ÿ” 10    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

A truly enjoyable and collaborative effortโ€”this is what science should be all about!

06.03.2025 19:51 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...

13.02.2025 13:18 โ€” ๐Ÿ‘ 27    ๐Ÿ” 16    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2
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Looking forward to hearing from the great speakers lined up for the โ€œ2025 Immcantation Users Group Meeting!โ€ Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social

17.01.2025 13:51 โ€” ๐Ÿ‘ 6    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social

www.biorxiv.org/content/10.1...

18.12.2024 15:20 โ€” ๐Ÿ‘ 27    ๐Ÿ” 13    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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An unbiased comparison of immunoglobulin sequence aligners Abstract. Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is critical for our understanding of the adaptive immune systemโ€™s dynamics in health an

Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners.
academic.oup.com/bib/article/...

26.11.2024 18:08 โ€” ๐Ÿ‘ 12    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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