Dominik Handler

📌

21.08.2025 21:46 — 👍 0    🔁 0    💬 0    📌 0

1/ How do animals develop immunity against a newly encountered transposable element from scratch? Our study reveals that the mobility of TEs is their Achilles heel, allowing hosts to develop a powerful small RNA-mediated silencing response.
www.biorxiv.org/content/10.1...

14.08.2025 17:09 — 👍 47    🔁 26    💬 4    📌 2

piRNAs are essential for transposon silencing in the animal germline.
But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response?

Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

03.08.2025 15:39 — 👍 60    🔁 20    💬 4    📌 1

Kristina Stapornwongkul and Sven Klumpe are new IMBA Group Leaders starting in 2025. Who will join IMBA in 2026? IMBA is hiring a Junior Group Leader. Apply to the position by May 18: imba.science/beagroupleader #hiring #biology #research #groupleader #europe

12.05.2025 07:00 — 👍 14    🔁 4    💬 0    📌 1

We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social

we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!

29.03.2025 13:22 — 👍 50    🔁 42    💬 0    📌 1

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

17.03.2025 11:56 — 👍 544    🔁 259    💬 11    📌 33

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

05.03.2025 16:02 — 👍 191    🔁 77    💬 12    📌 10

- EMBL with EMBL outstations
- Max Planck institutes in Germany (e.g. Dresden, Goettingen)
- Vienna BioCenter (IMP, IMBA, GMI, Max Perutz Labs)
- FMI Basel
- ETH Zürich
- CEITEC Brno
- CRG Barcelona
- Hubrecht Institute (Netherlands)
- EPFL Lausanne

01.03.2025 08:44 — 👍 17    🔁 7    💬 6    📌 1

Our lab is now on Bluesky! 🚀 Kicking things off by sharing
@fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!

12.02.2025 17:17 — 👍 32    🔁 8    💬 2    📌 0

Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chrom... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org/content/10.1...

04.10.2023 08:06 — 👍 0    🔁 0    💬 0    📌 0

A small but intriguing update on the Kipferl discovery by Lisa Baumgartner

Evolution of a specific binding mode between a ZnF protein and the HP1-variant Rhino.

A wonderful project with great help from Julius Brennecke, Hohmann Ulrich, Peter Duchek, Jon Ipsaro, Alex Schleiffer and me😉

04.10.2023 08:05 — 👍 7    🔁 1    💬 1    📌 0