Lucid Scientific

In this past study, an under-oil culture system was developed that stabilizes the microenvironment by reducing evaporation. Resipher was used to monitor oxygen consumption in hNPCs, confirming the creation of a low-oxygen, in vivo-like environment.

View it here >>> sciencedirect.com/science/arti...

Our march through Europe continues with next week's European Association for Cancer Research Neuroscience Conference, held in Spain. Lucid's Mike Lu will be representing our booth, exhibiting our #Resipher device and other technologies. Stop by and say hi!

Event info >>> eacr.org/conference/c...

The study investigates the mechanism by which the ceramide analog LCL768 induces mitophagy and metabolic stress in HNSCC. Resipher was used to measure real-time OCR over 24 hours to assess the impact of mitophagy on mitochondrial respiration.

View it here >>> aacrjournals.org/cancerres/ar...

Our busy fall event season continues on with next week's Cancer Metabolism Congress in France! Mike Lu will be representing Lucid, with a range of topics including host metabolic reprogamming. Stop by our booth and learn more about our Resipher technology.

Event info >>> www.metabolism-cancer.com

This study explores the physiological & metabolic consequences of whole-genome duplication using tetraploid C. elegans, organisms with four sets of chromosomes. Using Resipher, the team found that tetraploid worms displayed altered mitochondrial respiration profiles.

www.nature.com/articles/s41...

Science is hard. Resipher is easy.

With the #Resipher starter kit, you'll be ready to track long-term, real-time oxygen consumption rate (OCR) data in just minutes - opening up a world of new possibilities within your research. Learn more here >>> lucidsci.com/resipher

In this 4th edition of "Resipher in Action", we explore a research example that supports the role the technology can play in neurodegeneration and mitochondrial rescue.

View the paper here and learn how Resipher was used to provide direct supporting evidence >>> researchsquare.com/article/rs-6...

With Resipher and the new Timeprint Chart feature by Lucid Lab, track bioenergetic responses CONTINUOUSLY. Normalize to long-term pre-treatment baseline and capture the full picture of mitochondrial function.

View our Bioenergetic Profiling Guide to learn more >>> www.lucidsci.com/resources#do...

We're pleased to exhibit at next week's event organized by the Pathophysiology and Genetics of Neuron and Muscle, located in Lyon, France. We'll explore the latest research insights on tissue repair in health and disease.

Stop and say hi to Mike at the Lucid booth!

Event info >>> lnkd.in/er3np4gw

In this edition of "Resipher in Action", we explore the role the technology can play in cancer metabolism and therapeutic discovery.

Using Resipher, the team achieved real-time, non-destructive oxygen consumption measurements in intact neurospheres.

Publication >> sciencedirect.com/science/arti...

Introducing our new Timeprint Chart feature: a tool that provides deeper insight into your long-term oxygen consumption experiments, with the ability to analyze time-series inhibitor responses for bioenergetic profiling, therapeutic responses, or rescue assays (and much more).

Reach out for info!

Gearing up for another event in Germany in less than two weeks: the 48th ELC meeting in Tutzing. We're honored to be a contributing sponsor!

If you're planning on attending or will be in the area, stop by the Lucid Scientific booth and say hi to our very own Mike Lu.

Event link >>> eas-elc.org

Triolo and Khacho establish a protocol using the Resipher platform to measure mitochondrial oxygen consumption in live muscle stem cells and myoblasts over time.

Schedule your free Resipher demo >>> lnkd.in/ehMwTt5N

View the full publication here >>> lnkd.in/ePzAjHgF

Using Resipher for live, label-free metabolic analysis, the study confirmed enhanced mitochondrial capacity in these organoids, which recapitulated disease phenotypes including arrhythmia and fibrosis, and enabled successful drug screening for desmoplakin cardiomyopathy.

nature.com/articles/s44...

Tan et al. show that pericellular oxygen can become limiting in standard culture due to media depth, creating hypoxia‑like effects even in low‑density cultures. Resipher measurements uncovered steep oxygen gradients driven by media volume & other key findings.

pubmed.ncbi.nlm.nih.gov/38580776/

Ryan Titmas will be at the Lucid booth at next week's Adipose Biology Conference in Montreal, as scientists from around the world come together to propel groundbreaking advancements in mechanisms of adipose tissue biology.

Stop by our booth if you're attending! Show info here >>> adiposebiology.com

We're excited to be exhibitors and sponsors at this year's European Biological Rhythms Socity (EBRS) Congress! Mike Lu will be at our booth, ready to discuss our Resipher technology and the latest in chronobiology and sleep science.

Make plans to stop by our booth to learn more!

bit.ly/4mx2e7y

The publication demonstrates how Resipher enables sensitive measurement of OCR in C. elegans. The study provides detailed protocols for assessing mitochondrial function in live nematodes and highlights how variables critically impact OCR data interpretation.

sciencedirect.com/science/arti...

The FDA's recognition of the need for more predictive human cell models in preclinical testing provides credence to advances in the ability to generate, monitor and quality control human preclinical models of disease.

Learn more about the power of OCR and how Resipher can help >>> lucidsci.com/ocr

The Resipher platform was used to continuously measure OCR and evaluate whether lactate can serve as an oxidative fuel in glioma cells. The team found that neither mouse nor human cells could sustain viability or ATP production when glucose was replaced with lactate.

biorxiv.org/content/10.1...

Turn your 32- or 96-well plate into a dynamic, real-time oxygen consumption reader - in just minutes!

This short video describes the simple setup process involved with the 32-channel version of the Resipher. For more information or to request a free trial, click here >>> lucidsci.com/resipher

New insight into how mitochondrial metabolism drives the pro-inflammatory secretory phenotype (SASP) in oncogene-induced senescent (OIS) fibroblasts - using long-term, real-time oxygen consumption tracking with the Resipher system.

Read the publication here >>> www.sciencedirect.com/science/arti...

Excited for next week's AAIC show in Toronto! Lucid Global VP of Sales Ryan Titmas and Director of Customer Success Kin Lo will be set up at booth #1719 to exhibit our Resipher technology. Make plans to stop by if you're attending or in the area.

Show info here >>> aaic.alz.org

Mitochondrial impairment is a universal cause and/or consequence of cellular dysfunction. Resipher's ability to track mitochondrial respiration allows for the standardization of impairment & function levels that initiate and/or maintain disease pathologies.

Schedule a demo! >>> lucidsci.com

Researchers exhibit how 4-HMA and 4-HB can modify the course of mitochondrial encephalopathy driven by HPDL variants.

Turn your incubator into a data powerhouse!

Resipher is the first truly non-invasive oxygen consumption rate (OCR) mointoring system - capable of tracking OCR and other data over extended periods for invaluable insights into cellular metabolism.

Learn more >>> lucidsci.com/resipher

The authors investigated a novel strategy to stabilize neuronal cultures by growing them under a fluorinated oil overlay, which reduced media evaporation and increased environmental stability. Resipher was employed to measure oxygen consumption rate.

View it here >>> lnkd.in/eHQFfcxA

Optical sensors on the Resipher lid use non-invasive micro probes to dynamically scan above cells, measuring the oxygen concentration gradient that forms.

Our algorithms then convert concentration readings to cellular oxygen consumption in real-time.

Learn more >>> bit.ly/3VlQQAP

Resipher was used to monitor real-time oxygen consumption rate in HepG2 liver cells to investigate how pre-existing metabolic states associated with NAFLD. These insights emphasize the critical role of lipid metabolism in shaping mitochondrial vulnerability.

www.sciencedirect.com/science/arti...

Unlock the power of oxygen consumption rate (OCR) with Resipher - it provides valuable insight into metabolic activity, mitochondrial function, drug effects, and other key cellular processes.

Learn more and request a demo >>> lucidsci.com

#OCR #oxygenconsumption #mitochondria #resipher