Rong Fan

This stunning science art comes from a lymphoma case diagnosed by my incredible friend, hematopathology director Mina Xu. Art inspired by science brings awareness and hope, and helps patients.

💕💕💕

Feeling truly privileged to work with my amazing colleagues Mina Xu and Coraline Mlynarczyk in this project. Thank you!

We are incredibly grateful to Mark Foundation and Follicular Lymphoma Foundation for the ASPIRE award, supporting our research on decoding human follicular lymphoma progression and transformation.

I was unable to attend the YCC Annual Awards Ceremony this year due to urgent personal matters. When I heard the news, I was completely surprised and genuinely moved! Truly thankful to Yale Cancer Center for this recognition and the entire lab for their devotion to science! 🥰

Yale Cancer Center Annual Awards Formerly called the Conclave Awards, the 2025 Spring Yale Cancer Center awards honored research, clinical expertise, and support staff at the Hotel Marcel, New

I am incredibly honored and deeply grateful for receiving the 2024 YCC Translational Cancer Research Award! Thank you Yale Cancer Center from the bottom of my heart for this recognition and for your continued support! 💕

medicine.yale.edu/news-article...

@juliandownward.bsky.social @yuvalshaked.bsky.social @netaerez.bsky.social @idoamitlab.bsky.social @tcell.bsky.social @landau.bsky.social @zronai.bsky.social

Fabulous group photos from our recent conference in Athens !🎉 #MICC2025 Please feel free to share and tag :)
@peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social

ASTRO
Automated Spatial Whole-Transcriptome RNA-Expression wOrkflow
for Patho-DBiT
#SpatialRNAEncyclopedia
coding + noncoding RNAs

github.com/gersteinlab/...

vs ST-pipeline

Establishment of a non-coding RNA reference😎

@rongfan8.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...

#SpatialRNAEncyclopedia
Patho-DBiT
#SpatialTranscriptomics FFPE

Spatial Co-mapping of RNA Expression Splicing Editing SNV AND ncRNAs (miRNA lncRNA rRNA snRNA)👹

in situ polyA tailing

10 μm/px➡️ >2000 genes Lymphoma

@rongfan8.bsky.social @cellcellpress.bsky.social 2025
www.cell.com/cell/fulltex...

Connecting gene activity & precise location of protein function by Deterministic Barcoding in Tissue sequencing (DBiTplus)

📷: Archibald Enninful, Zhaojun Zhang et al
Mina Xu, Zongming Ma @rongfan8.bsky.social
@yale.edu in @biorxivpreprint.bsky.social

➡️: bpod.org.uk/archive/2025... &
AntDLewis

Just picked up the beautiful offprint of our Patho-DBiT paper that was on the cover of Cell, highlighting its power to spatially explore molecular biology in human FFPE tissues 🤩🤩 . Congratulations to my phenomenal postdoc Zhiliang Bai and all amazing collaborators!!

Congrats Dr.Zhang for your postdoctoral travel award! Way to go with spatial transcriptomics! #cmbe2025 @rongfan8.bsky.social @yalebooks.bsky.social @yaleengineering.bsky.social

Integrative spatial protein profiling with multi-omics - Nature Methods Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular ...

truly honored to write a commentary piece to discuss spatial protein profiling in the context of multi-omics !

www.nature.com/articles/s41...

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

SPATIAL PROTEOMICS is the Method of the Year 2024!!! 🤩🤩🤩

www.nature.com/articles/s41...

Incredible #epigenetics conference organized by @mpi-ie.bsky.social and a wonderful community!!!

Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus Spatially mapping the transcriptome and proteome in the same tissue section can significantly advance our understanding of heterogeneous cellular processes and connect cell type to function. Here, we ...

The second preprint presents an experiment workflow and a broadly applicable computional framework to integrate sequencing-based and imaging-based spatial omics data for the SAME tissue slide to construct a single cell spatial omics atlas.

www.biorxiv.org/content/10.1...

All-Optical Multimodal Mapping of Single Cell Type-Specific Metabolic Activities via REDCAT Metabolism dictates a range of physiological functions in human health and disease. Metabolic activities vary substantially in different cell types and are influenced by local tissue environments. Des...

The first preprint reports on an all optical approach to map metabolic activities and high-plex immunofluorescence cell typing in the SAME tissue section to link single cell omics to metabolic function cell-by-cell directly in complex tissues 🤩🤩

www.biorxiv.org/content/10.1...

My first post here on our research 🥳. Two preprints from my lab at Yale and Dr. Lingyan Shi’s lab at UCSD report same tissue section multi-modal spatial omics mapping! Please check them out. 🤩

Spatial Multi-Omics for Cancer Systems Biology Workshop! It is organized by our NCI-funded cancer systems biology center‬⁩. We will highlight talks by the leaders in the field as well as some hands-on experiences in computational analysis of spatial multi omics data!
isbscience.org/spatial-mult...