Teemu Strengell

Research in context panel for Lancet paper "The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis". Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

Antidepressants vary widely in their physical side effects, highlighting the need for personalised prescribing, says major meta-analysis.

Find out more: tinyurl.com/ycxzafd4

(A) Univariate correlation between eGFRcys and eGFRcr, and (B) scatterplot of eGFRcr versus eGFRdiff at baseline. Shown are correlations in a random 1% sample of 1,569 observations. The blue line shows the line of identity, and red line marks eGFRdiff higher and lower than 15mL/min/1.73m2. Abbreviations: cr, creatinine; cys, cystatin C; eGFR, estimated glomerular filtration rate.

Discordances Between Creatinine- and Cystatin C–Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practice

bit.ly/4491HQp #OpenAccess

New APA delirium guideline says NO to antipsychotics unless severe danger/distress. They failed in large trials:
www.psychiatry.org/getmedia/51e...

Use non-pharm approaches (and address underlying cause) in all patients, such as table 9:
pmc.ncbi.nlm.nih.gov/articles/PMC...

New 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults is here — developed with and endorsed by 12 leading organizations.

🫀 ow.ly/unFV50WGQFA

#CardioSky #MedSky @ajpcardio.bsky.social

Fingerstick blood glucose has comparatively poor sensitivity, with approximately 4 out of every 5 hypoglycemic events missed among nursing home residents. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Comparison of plasma p‐tau217/Aβ42, p‐tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease INTRODUCTION In clinically and racially diverse training and test sets, we evaluated and validated Alzheimer's disease (AD) plasma biomarkers: phosphorylated tau-217 (p-tau217), amyloid beta 1-42/1-.....

Comparison of plasma p‐tau217/Aβ42, p‐tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

⭐️ 📄 ⭐️

Recently @pharmermeg.bsky.social updated this open-access post. Originally published in 2017, the new version has a complete overhaul & provides a downloadable document. This is an article that has been read by by tens thousands of people 🌎🌍🌏.

www.idstewardship.com/cross-reacti... #IDsky

YouTube video by Dementia Researcher Blood Biomarkers & Testing for Alzheimer’s Disease

Blood Biomarkers: Testing for Alzheimer’s Disease

Professor Jonathan Schott @jmschott.bsky.social (UCL) explains how blood tests are reshaping Alzheimer’s diagnosis. Clear, current and clinically relevant.

Recorded at the Wessex Dementia Research Conference

youtu.be/3fLl1Mzwbsk

Listen to the episode!
[#FOAMed for Now]
emcrit.org/402

🔥🔥Just published 🔥🔥
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...

Woodworth et al. find that while LATE is the strongest predictor of hippocampal sclerosis of aging, vascular pathology is also independently associated—even after accounting for LATE. tinyurl.com/4m3zhjtn

"Lewy Body Dementia:  Future Directions" Webinar - Recording, Slides, and Resources - Brain Support Network Brain Support Network and Stanford's Movement Disorders Center are pleased to present Carla Abdelnour, MD, were pleased to present Stanford's Carla Abdelnour, MD, speaking on

Webinar now available online "Lewy Body Dementia: Future Directions" by Carla Abdelnour, MD @stanfordneuro.bsky.social @brainsupportnet.bsky.social rtnet.bsky.social @carlaabdelnour.bsky.social y.social

www.brainsupportnetwork.org/lbd-future-d...

Managing Hypercholesterolemia in Adults Older Than 75 years Without a History of Atherosclerotic Cardiovascular Disease: An Expert Clinical Consensus From the National Lipid Association and AGS. #geriatrics #medsky agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

I'm presenting today on High Dose #Psychiatry at the International Congress on Psychopharmcology in Turkey 4:30pm.

Hope to meet you if you're at the conference. Slides to the talk, which lays out what happens when we raise dose for various meds, here:
www.chrisaikenmd.com/highdosepsyc...

#pmhnp

Eve Marder has a nice commentary on our paper out in the Journal of General Physiology:

"What happened to the pursuit of truth?"

doi.org/10.1085/jgp....

Rivastigmine Use in the Treatment of Antimuscarinic Delirium

Recently saw anticholinergic toxicity in the ED. Physostigmine wasn’t available, so we used rivastigmine (6 mg caps & 13.3 mg patches) to reverse anticholinergic delirium/toxidrome—and it worked! #medsky #EMSky #Pharmsky #SkyRx

pmc.ncbi.nlm.nih.gov/articles/PMC...
pubmed.ncbi.nlm.nih.gov/38465631/

Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials We found evidence that GLP-1 receptor agonists significantly reduce clinically important kidney events, kidney failure, and cardiovascular events.

Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials 🔭🧑‍🔬🥼 #Diabetes #NephSky #CardioSky #Cardiovascular #Cardiovasculardisease #KidneyDisease #Type2Diabetes 👇👇

www.thelancet.com/journals/lan...

Won't someone please think of the cholinergic receptors? Asenapine sublingually for agitation, anyone?

The fast corrections are probably due to an underlying transient cause of hyponatremia (not necessarily anything to do with treatment). More severe reasons of hyponatremia result in more time in hyponatremia and slower corrections.

Could it be that the longer the patient is severely hyponatremic the more likely is the ODS?

ok, now do a thing with "time spent in severe hypoNa or symptomatic hypoNa" as a risk for ODS.