George Sflomos

There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday.

Learn more: eacr.org/conference/p...

EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight.

📅 29 September, 14:00-15:30 CEST
🌍 Zoom

us02web.zoom.us/meeting/regi...

Stand out in your career & boost your research impact 💥

Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.

Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...

Constructive Critics: Development's approach to peer review We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...

New @dev-journal.bsky.social editorial

We know we have high standards - but we're committed to making publishing with us constructive

From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science

journals.biologists.com/dev/article/...

Why scientists are flocking to Substack A new generation of researchers is using the platform to build audiences and monetize their knowledge.

Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪

Join us this November in Bergamo to help shape the future of early-onset cancer research!

We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.

In partnership with @themarkfdn.bsky.social 💙

eacr.org/conference/m...

Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers Chien-Chu Lin et al. reveal the structure of the histone demethylase KDM6B bound to the nucleosome. The study shows how KDM6B is positioned for H3K27 demethylation and how heterochromatin features suc...

Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers

www.cell.com/molecular-ce...

We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n

As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5

So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n

We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n

🚨 New podcast episode!

In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:

magazine.eacr.org/curiosity-op...

If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!

As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists.

#EACR2025

The evolutionary foundations of transcriptional regulation in animals Nature Reviews Genetics, Published online: 09 July 2025; doi:10.1038/s41576-025-00864-9In this Review, Coyle and King explore how genomic and functional data from diverse species are providing new insights into the types of mechanistic changes that accompanied the evolutionary origin of animals.

New online! The evolutionary foundations of transcriptional regulation in animals

What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...

Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.

Full house to attend to Eileen White keynote lecture on Cancer Metabolism with special focus on cancer cachexia! #EACR2025

Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!

How do tumors escape immune system?

Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025.
A truly inspiring opening to #EACR25

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

Acquired resistance in cancer: towards targeted therapeutic strategies

www.nature.com/articles/s41...

HER2 testing: evolution and update for a companion diagnostic assay - Nature Reviews Clinical Oncology The development of companion diagnostic assays enabling the detection and quantification of HER2 expression and ERBB2 amplifications has provided an important early example that has informed the devel...

Great overview on the evolving landscape of HER2 testing — from HercepTest to next-gen quantitative tools — and why precise detection of HER2-low matters more than ever in the era of ADCs.

www.nature.com/articles/s41...

Common Myths vs Facts about Invasive Lobular Carcinoma (ILC) - The Lobular Breast Cancer Alliance LBCA has developed a new patient resource to help clear up common and pervasive myths about invasive lobular carcinoma (ILC) and its treatment. Many misconceptions […]

LBCA has developed a new patient resource: Myths and Facts about Invasive Lobular Carcinoma to help clear up common and pervasive myths about invasive lobular carcinoma (ILC). Read it here: lobularbreastcancer.org/myths-vs-fac...

ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer - Nature Cancer Liang et al. study the impact of ERα antagonist/degraders against different Esr1 mutations in murine models and find that inhibition of mutant ERα induces lineage plasticity, which is also observed in...

ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer doi.org/10.1038/s430...

"Step out of your comfort zone and learn new things" - Seung Hyun Lee's EACR Travel Fellowship experience in America - The Cancer Researcher Seung Hyun Lee is a PhD student at the Cancer Research UK Manchester Institute and University of Manchester, UK who received an EACR Travel Fellowship to visit and work at Stanford University, US…

Seung Hyun Lee's EACR Travel Fellowship experience shows the value of embracing new environments and challenges in your life as a researcher, allowing you to accelerate your development and contribute meaningfully to the global fight against cancer:

Are you preparing for an upcoming interview in a science-related field? Don't miss our next interactive workshop is designed to equip you with the skills you need.

📅 09 June at 15:00216:30 CET
🌍 Zoom

us02web.zoom.us/meeting/regi...

We’re campaigning to #KeepResearchCurious because early-stage, curiosity-driven cancer research is the cornerstone of future medical breakthroughs 🔍 #EWAC2025

New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...

The promise and limitations of organoids for scientific research Organoids are a promising breakthrough that scientists have been exploring over the past 15 years. These three-dimensional tissue cultures grown from human stem cells stand to revolutionize some aspec...

Organoids are a promising breakthrough. These 3D tissue cultures grown from human stem cells stand to revolutionize some aspects of biomedical research, but they won’t eliminate the need for animal testing entirely.
actu.epfl.ch/news/the-pro...

Beautiful work from 🇨🇭@neuroxepfl.bsky.social #EPFL #CHUV