Simon Schultz

Thank you everyone for your suggestions! This turned out to be a very useful resource.

For those interested, you can see a compiled version of the suggestions from this thread here: tinyurl.com/kaz445jh

(The wiki page will be updated as we find more resources.)

🧠🤖 , 🧠📈

Just wait, the publishing industry will next introduce books with words that vanish as you read them: you want to read again, you pay again.

i'm sorry my review is late
i meant to read it weeks ago
but the writing
was actively hostile to comprehension
each paragraph
a slow erosion
of my will to live

Would if I could 😂

Excellent, thanks Marius - I hadn’t picked up that this paper used them.

Yep. Thanks Spencer.

Expression in these transgenic lines is quite a funny thing. We always have viral approaches as well, but for some very wide fov work I wanted to at least allow for using tg lines.

Thanks Michael! This is exactly what I wanted to know. And I assumed it must be something like this, given there is no paper yet, only that Janelia tech report. I am planning a grant and was thinking to base it on gcamp6 mice with costs included to upgrade technology if a usable line emerges.

Has anyone got any experience with gcamp8 transgenic mice yet? Eg the Thy1-GCaMP8s line?

janelia.figshare.com/articles/dat...

She was incredible. The song “Four Women” has to be one of the most powerful and moving pieces of music of all time.

Oh yes, I taught on that last year. I imagine it was just as hot this year! Did you manage to explore the Sanshirō Pond? Some beautiful gardens in the middle of campus, just a few hundred metres from the IRCN, and a nice place to escape the heat.

What incredible stuff.

I do love wet summer thunderstorms (I know it’s strange to qualify in that way but I grew up in an area where most years they were dry). In Japan I had a special borrowed umbrella for them that brought me luck, called “Lightning Conductor”.

The second of the hippocampus-inspired paintings by @anjiolina.bsky.social just came back from framing. I’m very happy with how it turned out.

Are you in Tokyo now?

I am definitely curious now

We do though. But the more clever cynical operators are good at doing just enough to look good on paper, without actually being all that helpful to peers.

😂 OK

Thus, close to Plaque, where neural Wonders cease,
The Dynamic Range finds not a Moment's Peace.
A deeper Insight into Mind's Decline,
This Tale of Cognitive Disease release.

The Place Fields, slow to blossom, late to bloom,
In Habit's Halls, or Novelty's wide Room.
A Fading Recall, Learning's weary Sigh,
Lost in the Shadows of an impending Gloom.

A Dynamic Range, diminished, brought to Naught,
Near Plaques' Embrace, a bitter Lesson taught.
Spatial Codes perplexed, their Meaning lost,
As Synchrony and Steadfastness were fought.

In 5xFAD, a mimicry of Pain,
The Hippocampus we observed again.
Its Neurons fired with unbridled Zeal,
Then hushed when Movement beckoned, all in vain.

With Two-Photon Gaze, we peered within,
To watch the Whispers where the Faults begin.
Amyloid Plaques, a cruel, white Stain,
Disturb the Order, ushering in Sin.

The Mind, a Palace built on fleeting Sands,
Where Memory's Echoes dance in Time's Commands,
By Alzheimer's Touch, its fabric rent,
A Tangled Web where Reason's Thread disbands.

The only good use I've managed to find for generative AI is rewriting my paper abstracts in quatrain.

The Mind's Decay, A Fading Light

I’m not convinced the USA will make it to 250.

Killer whales of Eden, New South Wales - Wikipedia

The killer whales off the coast of Eden, southern NSW, had a longstanding arrangement - first with the Yuin people then with European whalers - to cooperate in hunting baleen whales. This ended in the early 1900s, perhaps due to a visit by Norwegian whalers.

en.wikipedia.org/wiki/Killer_...

There is a lot in the paper - many person-years of work - please read it.

We mapped amyloid plaque locations in 3D and found that this reduced dynamic range was most pronounced near amyloid plaques. Many other analyses supported this - spatial information, response variability, modulation depth, slower place recall in familiar and acquisition in novel environments.

In older 5xFAD mice we found that baseline (resting) neural activity was elevated, but that neural activity during running (which should increase due to speed tuning and place fields) was lower compared to age-matched controls. This leads to a reduced dynamic range of neural activity.