Joel Selkrig

Excited to share new work by Guli Agirman + co that identifies a direct mechanism linking gut microbial imidazole propionate to stress! 🧠🦠 Btw this image was made by Nano Banana Pro 🍌. First time I've gotten a model to accurately generate a science graphic 🤯 authors.elsevier.com/a/1mA5M6t8JE...

An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...

A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.

The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA

Secreting bacteria undergo drastic changes.
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...

2025 Pettenkofer Prize awarded to Teresa Thurston - Dunn School The award by the Pettenkofer Foundation recognised Teresa’s contributions to identifying how different bacterial effectors impact the outcome of infection.

Many congratulations Teresa!

Teresa Thurston was awarded the 2025 Pettenkofer Prize, recognising her contributions to identifying how different bacterial effectors impact the outcome of infection.

www.path.ox.ac.uk/news-article...

Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.

#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky 🦠💊

www.nature.com/articles/s41...

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social

Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...

Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social

www.nature.com/articles/s42...

What if even the core of bacterial nanomachines wasn’t static?

We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.

🔗 www.nature.com/articles/s41...

@kit.edu @t3sss.bsky.social

hey sorry I only just noticed your message. super interesting thanks!

Thrilled to be part of this amazing team working to uncover how the human microbiome protects us from colonisation and infection by non-typhoidal Salmonella. Exciting science ahead!
#Microbiome #InfectionBiology #Salmonella #TeamScience

Software Developer You will contribute to the development of core database applications, web services, data ingestion workflows, and the PRIDE Web platform as part of the PRIDE ecosystem. Working closely with the team, ...

We are #hiring! 🚀

#PRIDE team is looking for a developer to build its future infrastructure. Our focus in a nutshell: #bigdata, single cell proteomics #SCP, & an #AI-oriented platform. Join us to shape the future of open proteomics data!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

Congratulations on this fantastic story Bella!

A host–pathogen arms race focused on dynamic regulation of the host epithelial barrier, wherein enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion @nature.com @genentech.bsky.social
www.nature.com/articles/s41...

We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...

Isolation, engineering and ecology of temperate phages from the human gut - Nature Human host-associated cellular products may act as induction agents for bacteriophages.

Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...

PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

Fantastic work Jeremy, a huge congratulations to you and your team!!!

Postdoctoral Research Assistant - MCDB - UOD2016 Closing date: Thursday 6 November 2025, 23:59

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.

www.dundee.ac.uk/work-for-us/...

Tronnet et al., Cell Rep. 2025 graphical abstract: Extracellular ATP is an environmental cue in bacteria

Our first effort exploring gut bacteria-extracellular ATP interactions is published! We show that eATP rewires gene expression and physiology in harmless and pathogenic bacteria, impacting production of bioactive metabolites, antimicrobial sensitivity, and virulence. A 🧵
www.cell.com/cell-reports...

Excited to share our preprint led by Carlos Voogdt et al

We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...

The functional landscape of the human ubiquitinome Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Important (and meticulous) genetic groundwork by the @typaslab.bsky.social and Carlos Voogt on gut microbiome Bacteroides species! Enormous value for the functional microbiome research community

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...

Targeted protein evolution in the gut microbiome by diversity-generating retroelements Diversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, su...

Fascinating Evo mechanism: diversity-generating retroelements (DGRs)! Highly abundant and frequently horizontally transferred - diversifying ligand-binding domains in gut Bacteroides! 🧪🦠 #microsky #microbiomesky
www.science.org/doi/10.1126/...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404

A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.

A new paradigm for outer membrane protein biogenesis in the Bacteroidota www.nature.com/articles/s41... #jcampubs

Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
1/4

Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies Abstract. Understanding the complex interactions between microbes and their environment requires robust model systems such as synthetic communities (SynCom

The main work from my time in Aachen is now out 🎉 if you have wanted to make a SynCom that captures the functional-landscape of microbiota, MiMiC2 makes that possible based on metagenomic data! 1/7 doi.org/10.1093/isme...

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇