Mariya Mardamshina

Great #iSCMS2025 poster by @mari-mardamshin.bsky.social, who presented mxDVP, integrating high-plex microscopy with ultra-sensitive MS to explore pancreatic islet heterogeneity at unprecedented resolution. Evosep One with Orbitrap Astral / timsTOF SCP, with Aurora Elite columns on both instruments.

Congratulations on your new team member!
What about WALL-E?

Honored to be featured in the Researcher Spotlight by @ionopticks.bsky.social, sharing my path to spatial proteomics and our efforts to build pipelines that decode cellular complexity and uncover hidden states.
#massspectrometry #spatialbiogy #proteomics #singlecell #multiplexedimaging #dvp

That’s exciting! Looking forward to test it out

It would be great if you could share how is your automation going, @justinwwalley.bsky.social

Opentrons now offers compatible with proteomics workflow automation solutions, including a thermocycler as one of the available options. You can check their protocol library library.opentrons.com/p/00d445_1

A portion of ye ole MS populace .. go.bsky.app/3XETWrh

Excited for the talk ✨🚀✨
#ASMS2025 #NASA #teammasspec #DRAGONFLY

🎉 Excited to share our work at #ASMS2025!
Come visit Poster WP300 to learn about our Multiplexed DVP (MxDVP) workflow - a streamlined approach integrating #high-plex #imaging and ultra-sensitive #MS for spatially resolved cell states.
Let’s talk #spatialbiology and #single-cell depth! #teammassspec

Sounds fun :)

Nano-scale, mega-impact: nanoPhos delivers 100× phosphoproteomics sensitivity, 70k sites from 1µg, 8k from 10ng! Powered by SPEC, it enables phosphoDVP: deep spatial phosphoproteomics from 1000 neurons, hitting 17k sites, a game changer for spatial omics.
www.biorxiv.org/content/10.1...

Another great reason to attend next year ☺️

🌅 What a fantastic start to the day here in Baltimore! Joined the 5K charity run this morning: great company, perfect views, and all for a wonderful cause. Huge thanks to @sciex.bsky.social for organizing such an awesome event!
#ASMS2025 #SCIEXRun #teammassspec

On my way to Baltimore for #ASMS2025! Excited to reconnect and dive into cutting-edge mass spectrometry.
Any must-see sessions or cool poster recommendations from the #teammassspec community? Looking forward to your suggestions!

So sorry for your loss 💔

Thank you for a life saving tip ☺️

Streamlining Multiplexed Tissue Image Analysis with PIPΣX: An Integrated Automated Pipeline for Image Processing and EXploration for Diverse Tissue Types Spatial proteomics via multiplexed tissue imaging is transforming how we study biology, enabling researchers to investigate dozens of markers in a single tissue section and explore how cells behave in...

Excited to share our new preprint: PIPΣX — an open-source, no-code pipeline for automated multiplexed tissue image analysis. Works across platforms & organs.

Explore here: www.biorxiv.org/content/10.1...

Looking forward for your feedback!
#spatialbiology #opensource #multiplexedimaging #massspec

Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets Pancreatic islets are highly specialized tissue compartments that regulate metabolism, and their dysfunction contributes to diseases such as prediabetes and diabetes. Characterizing islet morphology a...

Excited to share our preprint on multiplexed DVP! mxDVP extends CODEX to DVP family, revealing spatial heterogeneity in human pancreatic islets with 12 endocrine sub-types including rare polyhormonal cells. Fantastic team effort #LundbergLab biorxiv.org/content/10.1101/2025.04.27.650857v1

Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets Pancreatic islets are highly specialized tissue compartments that regulate metabolism, and their dysfunction contributes to diseases such as prediabetes and diabetes. Characterizing islet morphology a...

So excited to share our preprint!
We developed multiplexed Deep Visual Proteomics(mxDVP) to deeply profile human pancreatic islets at spatial single-cell resolution, and identified rare endocrine states
#SpatialOmics #Proteomics #SingleCell #IsletBiology #OpenScience
www.biorxiv.org/content/10.1...

Have you already heard about the #ProteomicsMap ? Check it out and find out what great labs are out there, to get help in your projects, collaborate, and network! Check it out here 👉 eupa.org/map/ . Also, don't forget to register 🫵 your proteomics group group.bspr.org/group/register !

Had the opportunity to join the the SAMBAI SPEAKS podcast, together with Dr. Roads, Dr. Olanipekun, and our patient advocate Lluvia Del Rio.
In this episode, we talked about work on the PROMINENT project, how we're exploring cancer development and why prevention deserves more attention in research.

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...

YouTube video by UCSF Cancer Unlocking Cancer Secrets with Peto’s Paradox. Cancer Grand Challenges: Introducing Team PROMINENT

youtube.com/watch?v=KaAv...

I began my proteomics journey 11 years ago during my PhD at Tel Aviv University in the Geiger group.

Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️

A Quantitative Proteome Map of the Human Body Proteomics analysis across human tissues from the GTeX resource reveals insight into tissue-specific pathways and phenotypes arising from genetic diseases.

A Quantitative Proteome Map of the Human Body

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www.cell.com/cell/fulltex...

Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma npj Precision Oncology - Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma

Our Deep Visual Proteomics workflow maps protein networks in bladder, prostate, seminal vesicle & lymph node Signet Ring Cell Carcinoma, revealing DNA damage response alterations & immune signatures that could guide therapy choice. Out now in NPJ Precision Oncology! rdcu.be/d8KyK

Yes, thank you :)

Release DIA-NN 2.0 · vdemichev/DiaNN We are excited to announce DIA-NN 2.0, the most significant milestone in the history of DIA-NN development. Key Breakthroughs Proteoform Confidence mode: DIA-NN 2.0 solves the long-standing chall...

DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...

Thank you :) will investigate that