Katie Gitin

Join Prof. Matthias Mann, Ph.D. from the Max Planck Institute as he shares his first-hand experience with the SCIEX ZenoTOF 8600 system—a next-generation, high-sensitivity, compact, and quantitative… Pushing proteomics forward: Prof. Matthias Mann on SCIEX ZenoTOF 8600 system at HUPO 2025

Watch Prof. Matthias Mann from the Max Planck Institute discuss the ZenoTOF 8600 at #HUPO2025. His presentation covers the transformative impact of this technology on protein analysis, focusing on enhanced sensitivity, quantitation, and real-world applications!

𝗪𝗵𝘆 𝗻𝗼𝘁 𝗷𝗼𝗶𝗻 𝗮 𝗻𝗲𝘄 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝘁𝘆 𝘁𝗵𝗶𝘀 𝘆𝗲𝗮𝗿❓ Check out the #BioACollective: Your Mass Spec Bioanalysis Community on #LinkedIn 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

Researcher Recess

🚨Philadelphia Researchers🚨
@sciex.bsky.social is hosting a Researcher Recess on 2/19 at White Dog Cafe in University City including:
-Delicious food & refreshing drinks
-Fun games and networking
-A chance to win exciting prizes

Save your spot here: sciex.com/Hidden/amer-...
#MassSpectrometry

𝗡𝗲𝘄 𝘆𝗲𝗮𝗿, 𝗻𝗲𝘄 𝗵𝗮𝗯𝗶𝘁𝘀? Join the #BioACollective: Your Mass Spec Bioanalysis Community to share ideas and meet like-minded people.

Join us on #LinkedIn today 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

Veloxity Labs Acquires SCIEX Accurate Mass Spectrometer, the ZenoTOF 8600 System, to Accelerate Peptide and Complex Bioanalysis The first bioanalytical CRO in the United States to bring the ZenoTOF 8600 system online; expands capacity and adds selectivity/sensitivity headroom for GLP-1 receptor agonists and broader peptide…

#DidYouHear? US-based CRO Veloxity Labs continues to expand its bioanalytical capabilities with the ZenoTOF 8600 system 👀

This marks a meaningful step forward in complex bioanalysis.

🔗 www.biospace.com/press-releas...

#MassSpec #Bioanalysis #Peptides #Proteomics #SCIEX #ZenoTOF8600

Multistage Tandem Mass Spectrometry Using an Electron-Activated Dissociation Device with a Linear Ion Trap and Structural Identification of Cardiolipins We have developed an electron-activated dissociation (EAD) device with product isolation functionality for multistage tandem mass spectrometry (MSn). The EAD portion is a branched magneto-radio freque...

pubs.acs.org/doi/10.1021/...

Beyond the Usual PFAS Suspects Mass spectrometry-driven non-targeted screening is revealing previously undetected PFAS in food, water, and the environment

Craig Butt from SCIEX explains how SWATH DIA mass spec is helping uncover the unknowns.
🔗 Read more: theanalyticalscientist.com/issues/2025/...
#PFAS #MassSpec #SCIEX #ScienceForGood #DanaherNews

Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments We present an optimized electron activated dissociation (EAD) methodology, based on hot electron capture dissociation, for liquid chromatography-tande…

Fantastic paper showcasing the power of EAD for glycopeptide annotation and glycan localization #ZenoTOF @sciex.bsky.social #PTMs
www.sciencedirect.com/science/arti...

SCIEX summit 2025 - a live virtual event Hear from industry experts about the latest advancements in mass spectrometry

🧪 Dan Selle from Texas A&M reveals how the Echo® MS+ system helps identify covalent inhibitors in tuberculosis research.
Don’t miss this session at #SCIEXSummit2025
🔗 sciex.com/events/sciex-summit

SCIEX summit 2025 - a live virtual event Hear from industry experts about the latest advancements in mass spectrometry

🧬 Patrick Schindler from #Novartis dives into IgA O-glycosylation using EAD and middle-up MS—advancing glycoprotein analysis.
Join live at #SCIEXSummit2025
🔗 sciex.com/events/sciex-summit

Interested in unraveling omega fatty acid positions in lipids? In this cooperation with @uni-grat.at, @ucsandiego.bsky.social we are able to use RP-MS/MS and LC=CL to achieve that. My lab contributed the EAD measurements using the ZenoTOF 7600 and the paper was published in @nature.com communication

A great showcase of @sciex.bsky.social's ZenoTOF 8600 system at #MSACL2025 today. Over 268,000 precursor and 12,000+ protein group IDs from just 200 ng of sample, with the Aurora Ultimate 25x75 XS & using Zeno SWATH DIA on the ZenoTOF 8600.
@davidcolquhoun.bsky.social, Ihor Batruch, & Patrick Pribil

Territory Manager, Mass Spectrometry - New Jersey job in Newark, New Jersey, United States of America | Sales jobs at Danaher Apply for Territory Manager, Mass Spectrometry - New Jersey job with Danaher in Newark, New Jersey, United States of America. Sales at Danaher

I am hiring! Do you have #massspec experience and are looking to get out of the lab and into sales? #chemjobs jobs.danaher.com/global/en/jo...

Evaluation of the False Discovery Rate in Library-Free Search by DIA-NN Using In Vitro Human Proteome Recently, deep-learning-based in silico spectral libraries have gained increasing attention. Several data-independent acquisition (DIA) software tools have integrated this feature, known as a library-free search, thereby making DIA analysis more accessible. However, controlling the false discovery rate (FDR) is challenging owing to the vast amount of peptide information in in silico libraries. In this study, we introduced a stringent method to evaluate FDR control using DIA software. Recombinant proteins were synthesized from full-length human cDNA libraries and analyzed by using liquid chromatography–mass spectrometry and DIA software. The results were compared with known protein sequences to calculate the FDR. Notably, we compared the identification performance of DIA-NN versions 1.8.1, 1.9.2, and 2.1.0. Versions 1.9.2 and 2.10 identified more peptides than version 1.8.1, and versions 1.9.2 and 2.1.0 used a more conservative identification approach, thus significantly improving the FDR control. Across the synthesized recombinant protein mixtures, the average FDR at the precursor level was 0.538% for version 1.8.1, 0.389% for version 1.9.2, and 0.385% for version 2.1.0; at the protein level, the FDRs were 2.85%, 1.81%, and 1.81%, respectively. Collectively, our data set provides valuable insights for comparing FDR controls across DIA software and aiding bioinformaticians in enhancing their tools.

Assessing FDR in proteomics using full proteome recombinant libraries: pubs.acs.org/doi/full/10..... A very elegant work and a benchmarking dataset useful for many other things too. Protein FDR higher than precursor FDR likely due to paralogues - and this needs to be researched further.

Advancing lipid identification in human plasma samples - Australia News Beep In this article, data-dependent acquisition (DDA) experimental data collected by the ZenoTOF 8600 system was analyzed with MS-DIAL 5.5 software to detect and

Advancing lipid identification in human plasma samples

https://www.newsbeep.com/au/2725/

In this article, data-dependent acquisition (DDA) experimental data collected by the ZenoTOF 8600 system was analyzed with MS-DIAL…

I'm really impressed by the Sciex developments with the ZenoToF 8600. Technically, it is 12k protein groups from 200 ng. It is a 3 species mixture. ~8k protein IDs are already a fantastic result.

Sciex in the game.

Pretty impressed by ScanningSWATH data on the new ZenoTOF 8600.

#TeamMassSpec

Exciting showcase of the accuracy, speed, & sensitivity of the new ZenoTOF 8600 system at #EuPA2025 today.

268,000+ precursor & 12,000+ protein group IDs from 200 ng of sample using Aurora Series columns & Zeno SWATH DIA on the ZenoTOF 8600. Impressive numbers from SCIEX’s new flagship instrument.

#InTheNews: SCIEX Sets a New Standard in Accurate Mass Quantitation With the ZenoTOF 8600 System and New Software Collaborations 👏 🎉

🔍 Read the article 👉 buff.ly/tyywuRu

#DanaherNews #ZenoTOF8600 #SkepticsWelcome

📢 Attention #ASMS2025 attendees!!

Stop by the service and support booth in the SCIEX Hospitality Suite to get helpful answers from the people who know your instrument best.

Our expert team shares real-world advice from supporting thousands of instruments worldwide!

TODAY is the LAST DAY to register for the SCIEX 5K Spring / Stroll for Science, taking place Sunday June 1st from 8:30-11:30am at the Baltimore Harbor Promenade and the Maryland Science Center!

Throw your trainers and your running gear in your suitcase and register now 👉 sciex.li/1pw179 #ASMS2025

Something is coming... 👀

Get a sneak peek now 🔗 youtu.be/vnOJN_rAakw

#ASMS2025 #SkepticsWelcome

We are super thrilled to see ZT Scan DIA leading to insight from miniscule proteome samples, in clinical proteomics and functional proteomics studies that depend on highly precise protein quantification from large sample series.

Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput Proteomic experiments, particularly those addressing dynamic proteome properties, time series, or genetic diversity, require the analysis of large sample numbers. Despite significant advancements in p...

I am excited to see our performance assessment of the successor of Scanning SWATH on the Zeno TOF7600+ mass spectrometer - ZT Scan DIA - pre-printed (www.biorxiv.org/content/10.1...

Research on GLP-1 is crucial due to its widening therapeutic scope. #LCMSanalysis is used in #GLP1 research due to its sensitivity, specificity, and versatility. Check out the #SpotlightOnSeries for more information: bit.ly/41sahev

#Quantitation #SCIEX

Awesome application!!

Arthropod Parasitiformes amber inclusions. (A) Holothyrida, Neothyridae. A scavenger mite found together with insect inclusions in the amber from which it was separated for analysis. The figures provide details of the general look of the piece, measurements, and critical details for identification. Insect inclusions and amber without inclusions derived from this amber piece were processed as controls. (B) Cornupalpatum tick species for which stereomicroscope and Scan Ct images show the damage of the body preventing an accurate determination to the species level.

Neothyridae gen. sp. Elongation factor 1-alpha (A0A2H4RIF7). Sequence and phylogenetic analysis of the protein identified with highest coverage (244/342 amino acids, 71.3%). Neothyridae form a separate clade within Holothyrida mites.

Thread 1/5: PREPRINT: A major milestone on #Paleoproteomics?

Sciex 6600 TripleTOF analyses 99-million-year-old arthropods 🕷️ in amber.

Study identifies proteins from #Cretaceous #Holothyrida mites & #Cornupalpatum ticks!

de la Fuente et al. (2025) www.researchsquare.com/article/rs-6...

Mass spectrometry is a tool to deliver quantitative biological insights. Join Birgit Schilling at the SCIEX lunch seminar on Tuesday February 25th to discover how her lab is using the ZenoTOF 7600+ system to innovate proteomics workflows. #USHUPOSponsor #SponsoredPost

When is CID not enough for your research? At SCIEX, we’ve found some novel applications of hybrid and electron-based fragmentation to better characterize PTMs, including phospho- and glycopeptides. How else can EAD help biological insights? #USHUPOSponsor #SponsoredPost

Establishing a Top-Down Proteomics Platform on a Time-of-Flight Instrument with Electron-Activated Dissociation Top-down proteomics is the study of intact proteins and their post-translational modifications with mass spectrometry. Historically, this field is more challenging than its bottom-up counterpart because the species are much bigger and have a larger number of possible combinations of sequences and modifications; thus, there is a great need for technological development. With improvements in instrumentation and a multiplicity of fragmentation modes available, top-down proteomics is quickly gaining in popularity with renewed attention on increasing confidence in identification and quantification. Here, we systematically evaluated the Sciex ZenoTOF 7600 system for top-down proteomics, applying standards in the field to validate the platform and further experimenting with its capabilities in electron-activated dissociation and post-translational modification site localization. The instrument demonstrated robustness in standard proteins for platform QC, as aided by zeno trapping. We were also able to apply this to histone post-translational modifications, achieving high sequence coverage that allowed PTM’s site localization across protein sequences with optimized EAD fragmentation. We demonstrated the ability to analyze proteins spanning the mass range and included analysis of glycosylated proteins. This is a reference point for future top-down proteomics experiments to be conducted on the ZenoTOF 7600 system.

New manuscript from the lab to establish a Top Down MS platform using electron activated dissociation on the Sciex ZenoTOF 7600 is out at the Journal of Proteome Research!

pubs.acs.org/doi/full/10....