Amy McCart Reed

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast Invasive lobular carcinoma of the breast (ILC) are typically estrogen receptor α (ER)-positive and present with biomarkers of anti-estrogen sensitive disease, yet patients with ILC face uniquely poor ...

Exciting update to our #lobular breast cancer work with DNA repair and PARP inhibition, ahead of @sabcs.bsky.social next week! #oncosky #bcsm
www.biorxiv.org/content/10.1...

Despite lacking "BRCA-like" mutations and features, we find ILC models are sensitive to PARPi in vivo. Why? 🧵 1/n

Amazing stuff Matt and team #lobular👏👏👏

Dharmesh maybe not loving the spotlight (in his eyes) 🔦🔦🔦🤣🤣🤣 #SpaNorm #multiomics2024 @bhuvad.bsky.social

Watching @anandpatellab.bsky.social give a masterclass in collaboration for #multiomic analysis of #neuroblastoma #multiomics2024

#uqccr #uq represent! Prof Salomon wowing the crowd again #multiomics2024 #evs#extracellularvesicles #ovariancancer

Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information

Amazing end to Day1 of #multiomics2024 Already excited for tomorrow’s talks #brisbane #breastcancer #metaplastic

When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳

bulk RNA-seq: a big pile of different colored legs all mixed up single-cell RNA-seq: small piles of Legos organized by color spatial transcriptomics: image of the brain built out of Legos

An analogy of the differences between bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics

#multiomics2024 10/

Tumors: an ecosystem of interacting and inter-dependent cellular communities: "seed vs soil" Define complexity of the TME @single cell-spatial resolution Composition (identities) Lineage and dynamics Gene regulatory networks (GRNS) Specialized functions Cell-cell interactions (tumor-stroma-immune) Investigate mechanisms of cross-regulatory interactions drive cancer cell plasticity define intra-tumor phenotypic heterogeneity modulate therapy response

It is not enough to study cancer cells in isolation. Tumors are an ecosystem of interacting & inter-dependent cellular communities: "seed vs soil."

#multiomics2024 5/

Forget livetweeting we are now live illustrating!!!! #headandneck #multiomics2024

Kicking off #multiomics2024 in style here in Brisbane. So sorry about the humidity everyone!!!

If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs