Cancer Dormancy Institute @ Einstein

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

Please join me in congratulating the newly minted Dr. Madeline Friedman DeLuca! She did a phenomenal job in her thesis defense today!

#ProudPI

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

montefioreeinsteinnow.org/update/2025-...

Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells Mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. Boutet, Nishitani, et al. show that the loss of MLL3 stabilizes HIF1α, which induces express...

New work from CDI members @wenjunguolab.bsky.social and Gregoire Lauvau published in Immunity. Congrats! www.cell.com/immunity/abs...

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

Accompanying pieces www.nature.com/articles/d41...

Inflammation during viral infection can rouse dormant cancer cells Sometimes, cancer cells that have spread become ‘dormant’ but can start proliferating again later. A cue that can reactivate them has been discovered.

www.nature.com/articles/d41...

@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening

Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps Disseminated tumor cells (DTCs) can remain in a non-proliferative, dormant state for years in distant organs, but the exogenous causes triggering thei…

www.sciencedirect.com/science/arti...

IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis - Nature Immunology Cellular exhaustion can limit the ability of immune cells to control tumors. Here the authors show that expression of the transcription factor Irf4 marks NK cell percursors that will go on to become e...

www.nature.com/articles/s41...

Neuroprotective liver portal area macrophages attenuate hepatic inflammation - Nature Immunology Zhang and colleagues characterize a subset of nerve-associated CX3CR1+ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

www.nature.com/articles/s41...

Reversible proliferative arrest induced by rapid depletion of RNase MRP - Nature Communications Cellular quiescence is a reversible dormant state that helps cells survive stress, support tissue regeneration, and promote longevity. Here, the authors show that blocking ribosomal RNA production by ...

www.nature.com/articles/s41...

Great moment with the lab celebrating Lucía Petriz Otaño🇦🇷 passing her PhD qualifying exam and receiving her MSc!! Congratulations! We are very proud of you! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Midkine inhibits dormancy of disseminated melanoma cells A significant factor in cancer-related mortality in melanoma is the appearance of intrinsically aggressive distal metastases. This recurrence frequently results from the awakening of dormant dissemina...

Important findings from the @soledadsosalab.bsky.social at the @cdi-einstein.bsky.social at Montefiore Einstein Comprehensive Cancer Center on the mechanisms of dormant cutaneous melanoma awakening via midkine dependent signaling. Congrats on this story!
www.biorxiv.org/content/10.1...

Arrived to Lisbon for the 2025 EACR @helloeacr.bsky.social @cdi-einstein.bsky.social

Delighted to have contributed to the tumor dormancy session at @helloeacr.bsky.social thanks @casanova-acebes.bsky.social for the pic! @cdi-einstein.bsky.social

Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer | EMBO Molecular Medicine imageimageNCoR1/RARα interaction was identified as a target for selective chaperone-mediated autophagy (CMA) inhibition in lung cancer. A first-in-class small molecule CMA inhibitor targeting this int...

New work from CDI member Evris Gavathiotis our in EMBO Molecular Medicine. Congrats!
www.embopress.org/doi/full/10....

Proteostasis in cellular dormancy: lessons from yeast to oocytes Cellular dormancy is characterized by a prolonged, reversible cell cycle arrest and absence of growth. Dormancy allows organisms to endure unfavorable…

www.sciencedirect.com/science/arti...

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 - Molecular Cancer Epithelial-to-mesenchymal transition (EMT) is a crucial cellular process for embryogenesis, wound healing, and cancer progression. It involves a shift in cell interactions, leading to the detachment o...

link.springer.com/article/10.1...

www.pnas.org/doi/abs/10.1...

While the CDI Service Core will initially focus on internal programs we encourage those in industry or academic centers that are interested in inquiring about our services to reach out to our team.

Cancer Dormancy Institute Service Core | Montefiore Einstein Comprehensive Cancer Center | Patient Care | Montefiore Einstein Support your cancer dormancy research with expert models, markers, and protocols from Montefiore Einstein’s Cancer Dormancy Institute Service Core.

The CDI announces the launch of the Cancer Dormancy Institute Service Core. The Core provides expert advice on markers, mouse, avian and 3D models, protocol development and rare cell isolation methods to explore dormancy, MRD & relapse biology across cancers.
montefioreeinstein.org/cancer/resea...

Today we have the pleasure to hear Dr. Ana Gomes @moffittnews.bsky.social deliver a CDI Virtual Seminar. Thanks for meeting with us!

Congratulations !

We are proud to share that @alanawelm.bsky.social, PhD, has been named chair of Oncological Sciences at @utah.edu. A global leader in breast cancer research, she brings deep vision, collaboration, and impact to this new role. Please join us in congratulating Dr. Welm. Learn more: bit.ly/3H3GqB3

Congratulations to Dr. Britta Will for being named Director of the Gottesman Institute for Stem Cell Biology and Regenerative Medicine @einsteinmededu.bsky.social !! Hugely deserved! Looking forward to growing our collaborations @cdi-einstein.bsky.social & the Stem Cell Institute!

New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service!
aacrjournals.org/cancerres/ar...

MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization - Nature Cancer Guetter et al. identify a melanoma-associated chondroitin sulfate proteoglycan-positive subpopulation of metastasis founder cells from lymph node biopsies of patients with melanoma and observe that th...

www.nature.com/articles/s43...

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy Recurrent breast cancer accounts for most disease-associated mortality and can develop decades after primary tumor therapy. Recurrences arise from residual tumor cells (RTCs) that can evade therapy in...

www.biorxiv.org/content/10.1...

How Do Dormant Cancer Cells Become Metastases? The interplay between dormant cancer cells and components of the immune system appears to heavily influence if cancer later returns as metastatic disease.

Three @cdi-einstein.bsky.social investigators highlighted in news outlets for their work and expertise via “Einstein in the News” Congrats!

www.cancer.gov/news-events/...

www.msn.com/en-us/news/p...

www.science.org/content/arti...

KRASG12D Cells Override Homeostatic Cell Elimination Mechanisms in Adult Pancreas Via Wnt5a and Cell Dormancy The adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutation…

www.sciencedirect.com/science/arti...