Cancer Dormancy Institute @ Einstein

We wrapped the @cdi-einstein.bsky.social Retreat with four impressive projects from our workshop by Unai Heras Manterola, Lindsay Lafave, Maria Sosa, and Kamini Singh—covered dormancy & bioengineering, neoantigens, transcriptional heterogeneity & lung cancer. Wow! Thanks to all who participated!

Now Wenjun Guo @cdi-einstein.bsky.social presenting his work on MLL3 loss and metastasis initiation.

Today we had a phenomenal first day of our @cdi-einstein.bsky.social retreat. Great talks by @soledadsosalab.bsky.social Anna Skwarska and John McAuliffe.

Exciting to wrap up the presentations at our CDI retreat with two phenomenal talks by @cdi-einstein.bsky.social latest recruits who will start in 2026 @swagatag.bsky.social from @mit.edu and @samhegde.bsky.social from @mountsinainyc.bsky.social welcome to @einsteinmededu.bsky.social

The @cdi-einstein.bsky.social retreat is tomorrow! Featuring 1.5 days of exciting science with keynote by Dr. Lewis Chodosh (UPenn) and talks from our faculty and students. Thanks to MECCC, SWCRF, and Pershing Square Philanthropies for their support!

Getting ready to start our @cdi-einstein.bsky.social Retreat!

Now the Keynote Lecture at our @cdi-einstein.bsky.social retreat delivered by @amulyasreekumar.bsky.social from the Chodosh team at University of Pennsylvania - great work!

Exciting science presented by @wenjunguolab.bsky.social !

A day of exceptional science delivered by CDI Members. Thanks for joining the Retreat!

Anti-progestin therapy targets hallmarks of breast cancer risk - Nature Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...

www.nature.com/articles/s41...

The CDI retreat is only one day away! 1.5 days of exciting science including our keynote speaker Dr. Lewis Chodosh @upenn.edu and talks by our members and new recruits (TBA soon)! Thanks to MECCC, Samuel Waxman Cancer Research Foundation & Pershing Square Philanthropies for their support!

The MRS is excited to announce the awardees for the 2026 MRS Awards. Congratulations to all of the awardees! 🏆 Paget-Ewing Award (Honoring scientific excellence and substantial contributions to… | M... The MRS is excited to announce the awardees for the 2026 MRS Awards. Congratulations to all of the awardees! 🏆 Paget-Ewing Award (Honoring scientific excellence and substantial contributions to the ...

CDI Director Dr. Aguirre-Ghiso receives highest honor from the metastasis research society. Importantly, this & the Fidler Innovation Award to Dr. Cyrus Ghajar at @fredhutchprotons.bsky.social recognize the discoveries and research on cancer dormancy.
www.linkedin.com/posts/metast...

FAK Inhibition Demonstrates Dual Effects of Tumor
Suppression and Dormancy Induction Through
Region-Specic COUP-TF1 Regulation
assets-eu.researchsquare.com/files/rs-761...

Congratulations to CDI Member Eugen Dhimolea and collaborators at CDI and elsewhere for their recent publication revealing vulnerabilities of quiescent triple negative breast cancer cells persisting after chempotherapy : www.mdpi.com/2073-4409/14...

Congratulations to Rebeca San Martin @rsm7.bsky.social and Soledad Sosa @soledadsosalab.bsky.social for receiving the 2025 CDI Pilot Grant entitled "Elucidating the chromatin architectures between cancer dormancy and recurrence", which focuses on converging mechanisms in prostate cancer & HNSCC.

The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia - Nature Communications Infant KMT2A-rearranged acute lymphoblastic leukemia is associated with poor overall survival rates. Here, the authors use WGS and WES of 36 relapsed KMT2A-rearranged ALL and AML patients and find alterations in drug response genes in ALL, which may correspond with relapse time. Longitudinal analyses of >250 samples could track residual leukemia cells, clonal drug responses, and the upcoming relapse.

www.nature.com/articles/s41...

Congratulations to Dr. Sosa @soledadsosalab.bsky.social, one of CDI’s inaugural recruits, on this remarkable recognition by @susangkomen.bsky.social!

This well-earned honor exemplifies and strengthens the transformative research vision at @cdi-einstein.bsky.social & @einsteinmededu.bsky.social

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer Tumor dissemination is increasingly recognized to begin early in tumor development. Although most of these early disseminated cells are cleared, some survive and persist below clinical detection, acti...

www.biorxiv.org/content/10.1...

Congrats to Shoichiro Takeishi, @steidluli.bsky.social @gritsmanlab.bsky.social and co-authors on this fascinating discovery! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Excited about a day of exceptional cancer science being developed at our @einsteinmededu.bsky.social comprehensive cancer center. Featuring science being developed at our Cancer Dormancy Institute @cdi-einstein.bsky.social - proud to be part of this amazing community

Delighted to have opened this fantastic meeting in beautiful Thessaloniki organized by the equally amazing Evi Lianidou presenting updates from the lab @cdi-einstein.bsky.social including our CH collaborative work with @rosslevinemd.bsky.social lab.

www.erasmus.gr/microsites/1...

I could not stay the entire meeting but it was great seeing friends and colleagues Evi Lianidou, Angela Nieto AndreasTrumpp Caroline Dive and many more at the 7th ACTC Meeting in Thessaloniki, Greece. Great to bring the science we are developing @cdi-einstein.bsky.social to this meeting.

Delighted to host Dr. Javier Bravo Cordero at our Cancer Dormancy Institute Seminar Series. Don't miss his exceptional work! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality - OncoDaily Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality / Adrienne Boire, Alexander Yang, Allison W. Kurian, Amy B. Knudsen, Amy

oncodaily.com/voices/metas.... Thanks for sharing this post with a broader audience @oncodaily.bsky.social the goal of our @cdi-einstein.bsky.social is to bring new science for interception of metasasis / recurrence and MRD at its earliest point.

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

Amazing work from investigators at the @cdi-einstein.bsky.social. Congrats @divijverma.bsky.social and team! Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion url: aacrjournals.org/cancerdiscov...

CD138 and APRIL regulate plasma cell survival, competition, and retention in the bone marrow niche Survival of new PCs after vaccination is highly variable, inefficient, and poorly understood. Park et al. demonstrate that higher cell-intrinsic CD138 levels control PC survival in competitive environ...

New work from CDI Member Dr. David Fooksman- Congrats! www.cell.com/cell-reports...

Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation - British Journal of Cancer British Journal of Cancer - Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation

New study from CDI member Rachel Hazan. Congrats!
www.nature.com/articles/s41...

Important study showing that targeting dormant residual disseminated cancer cells can reduce MRD burden by Angela DeMichele, collaborator and Lewis Chodosh @penncancer.bsky.social who will be Keynote Speaker at our next CDI retreat! Congratulations!

Haematopoietic stem cell number is not solely defined by niche availability - Nature Haematopoietic stem cell numbers are restricted at both systemic and local levels.

New findings by CDI members @steidluli.bsky.social @gritsmanlab.bsky.social et al.,reveal how HSC numbers are controlled by both systemic & local (niche) mechanisms, primarily regulated by thrombopoietin, even with increased niche capacity. Congrats to all! www.nature.com/articles/s41...