Cancer Dormancy Institute @ Einstein

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer Tumor dissemination is increasingly recognized to begin early in tumor development. Although most of these early disseminated cells are cleared, some survive and persist below clinical detection, acti...

www.biorxiv.org/content/10.1...

Congrats to Shoichiro Takeishi, @steidluli.bsky.social @gritsmanlab.bsky.social and co-authors on this fascinating discovery! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Excited about a day of exceptional cancer science being developed at our @einsteinmededu.bsky.social comprehensive cancer center. Featuring science being developed at our Cancer Dormancy Institute @cdi-einstein.bsky.social - proud to be part of this amazing community

Delighted to have opened this fantastic meeting in beautiful Thessaloniki organized by the equally amazing Evi Lianidou presenting updates from the lab @cdi-einstein.bsky.social including our CH collaborative work with @rosslevinemd.bsky.social lab.

www.erasmus.gr/microsites/1...

I could not stay the entire meeting but it was great seeing friends and colleagues Evi Lianidou, Angela Nieto AndreasTrumpp Caroline Dive and many more at the 7th ACTC Meeting in Thessaloniki, Greece. Great to bring the science we are developing @cdi-einstein.bsky.social to this meeting.

Delighted to host Dr. Javier Bravo Cordero at our Cancer Dormancy Institute Seminar Series. Don't miss his exceptional work! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality - OncoDaily Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality / Adrienne Boire, Alexander Yang, Allison W. Kurian, Amy B. Knudsen, Amy

oncodaily.com/voices/metas.... Thanks for sharing this post with a broader audience @oncodaily.bsky.social the goal of our @cdi-einstein.bsky.social is to bring new science for interception of metasasis / recurrence and MRD at its earliest point.

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

Amazing work from investigators at the @cdi-einstein.bsky.social. Congrats @divijverma.bsky.social and team! Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion url: aacrjournals.org/cancerdiscov...

CD138 and APRIL regulate plasma cell survival, competition, and retention in the bone marrow niche Survival of new PCs after vaccination is highly variable, inefficient, and poorly understood. Park et al. demonstrate that higher cell-intrinsic CD138 levels control PC survival in competitive environ...

New work from CDI Member Dr. David Fooksman- Congrats! www.cell.com/cell-reports...

Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation - British Journal of Cancer British Journal of Cancer - Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation

New study from CDI member Rachel Hazan. Congrats!
www.nature.com/articles/s41...

Important study showing that targeting dormant residual disseminated cancer cells can reduce MRD burden by Angela DeMichele, collaborator and Lewis Chodosh @penncancer.bsky.social who will be Keynote Speaker at our next CDI retreat! Congratulations!

Haematopoietic stem cell number is not solely defined by niche availability - Nature Haematopoietic stem cell numbers are restricted at both systemic and local levels.

New findings by CDI members @steidluli.bsky.social @gritsmanlab.bsky.social et al.,reveal how HSC numbers are controlled by both systemic & local (niche) mechanisms, primarily regulated by thrombopoietin, even with increased niche capacity. Congrats to all! www.nature.com/articles/s41...

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

Please join me in congratulating the newly minted Dr. Madeline Friedman DeLuca! She did a phenomenal job in her thesis defense today!

#ProudPI

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

montefioreeinsteinnow.org/update/2025-...

Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells Mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. Boutet, Nishitani, et al. show that the loss of MLL3 stabilizes HIF1α, which induces express...

New work from CDI members @wenjunguolab.bsky.social and Gregoire Lauvau published in Immunity. Congrats! www.cell.com/immunity/abs...

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

Accompanying pieces www.nature.com/articles/d41...

Inflammation during viral infection can rouse dormant cancer cells Sometimes, cancer cells that have spread become ‘dormant’ but can start proliferating again later. A cue that can reactivate them has been discovered.

www.nature.com/articles/d41...

@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening

Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps Disseminated tumor cells (DTCs) can remain in a non-proliferative, dormant state for years in distant organs, but the exogenous causes triggering thei…

www.sciencedirect.com/science/arti...

IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis - Nature Immunology Cellular exhaustion can limit the ability of immune cells to control tumors. Here the authors show that expression of the transcription factor Irf4 marks NK cell percursors that will go on to become e...

www.nature.com/articles/s41...

Neuroprotective liver portal area macrophages attenuate hepatic inflammation - Nature Immunology Zhang and colleagues characterize a subset of nerve-associated CX3CR1+ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

www.nature.com/articles/s41...

Reversible proliferative arrest induced by rapid depletion of RNase MRP - Nature Communications Cellular quiescence is a reversible dormant state that helps cells survive stress, support tissue regeneration, and promote longevity. Here, the authors show that blocking ribosomal RNA production by ...

www.nature.com/articles/s41...

Great moment with the lab celebrating Lucía Petriz Otaño🇦🇷 passing her PhD qualifying exam and receiving her MSc!! Congratulations! We are very proud of you! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Midkine inhibits dormancy of disseminated melanoma cells A significant factor in cancer-related mortality in melanoma is the appearance of intrinsically aggressive distal metastases. This recurrence frequently results from the awakening of dormant dissemina...

Important findings from the @soledadsosalab.bsky.social at the @cdi-einstein.bsky.social at Montefiore Einstein Comprehensive Cancer Center on the mechanisms of dormant cutaneous melanoma awakening via midkine dependent signaling. Congrats on this story!
www.biorxiv.org/content/10.1...

Arrived to Lisbon for the 2025 EACR @helloeacr.bsky.social @cdi-einstein.bsky.social

Delighted to have contributed to the tumor dormancy session at @helloeacr.bsky.social thanks @casanova-acebes.bsky.social for the pic! @cdi-einstein.bsky.social

Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer | EMBO Molecular Medicine imageimageNCoR1/RARα interaction was identified as a target for selective chaperone-mediated autophagy (CMA) inhibition in lung cancer. A first-in-class small molecule CMA inhibitor targeting this int...

New work from CDI member Evris Gavathiotis our in EMBO Molecular Medicine. Congrats!
www.embopress.org/doi/full/10....

Proteostasis in cellular dormancy: lessons from yeast to oocytes Cellular dormancy is characterized by a prolonged, reversible cell cycle arrest and absence of growth. Dormancy allows organisms to endure unfavorable…

www.sciencedirect.com/science/arti...