Pauline Franz

I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...

Dear world: this is what a graphical abstract is supposed to look like.

A Site‐Specific Click Chemistry Approach to Di‐Ubiquitylate H1 Variants Reveals Position‐Dependent Stimulation of the DNA Repair Protein RNF168 We developed a click chemistry approach to di-ubiquitylate histone H1 at relevant DNA repair-associated positions (H1KxUb2) to probe its effect on the E3 ligase RNF168. We demonstrate that H1KxUb2 st...

Check out our #openaccess article "A Site-Specific Click Chemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168"
▶️ tinyurl.com/27uxumme
@beatfierz.bsky.social

Frontispiece of Angewandte Chemie Int. Ed. showing a pop-art style drawing of protein structures and a hand symbolizing the protein RNF168.

What a great conclusion to my final days at EPFL: our 🔥article is highlighted on the @angewandtechemie.bsky.social Frontispiece!!

▶️ tinyurl.com/mvtecrsz

@beatfierz.bsky.social #chemicalbiology #clickchemistry #DNArepair #SciArt🐡 🧪

Hi there: we're happy to be on BlueSky now, too! Stay tuned as we're getting set up here for the #ChemSky community - more to follow soon!

🥳 Today we celebrated the PhD defense of our very first PhD student Kevin Schiefelbein 🤩 Kevin told us about his Lasso Peptide journey over the past four years, and it was so great to see the full story coming together. Congratulations Kevin, and thank you for everything! #proudPI

Four panel meme based on the worst Star Wars film. Altmetric is tracking Myspace.

We want to thank everyone for joining and to congratulate the winners! A big thank you to all sponsors supporting this meeting!

We hope to see you all next time.
#LS2 #ICMT #Biophysics #LifeScience #Switzerland #Conference #Science

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.

www.biorxiv.org/content/10.1...

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️

Cephalopod-inspired jetting devices for gastrointestinal drug delivery - Nature Tethered or ingestible delivery systems that deliver liquid microjets in axial and radial directions can be used to deliver macromolecules to different parts of the gastrointestinal tract with good bi...

MIT researchers in collaboration with Novo Nordisk report in Nature an alternative to injections for the delivery of biologic drugs. This needle-free method leverages an ingestible capsule inspired by squids that releases drugs directly into the digestive tract wall. www.nature.com/articles/s41...

On November 20, the new class of peptide-cyanobenzene dye photocatalysts developed by Xingyu have been first made public in a preprint at ChemRxiv, including a great collaboration Wei Cai in the @beatfierz.bsky.social group and Dr. Anne Sophie Chauvin
chemrxiv.org/engage/chemr...

SPY555-FastAct stained intestinal organoids growing in in microwells. the image is a composite of a brightfield image (grey) and SPY555-FastAct (cyan).

Celebrating #FluorescenceFriday and hopefully brightening your timeline with these live intestinal #organoids stained with our actin probe SPY555-FastAct.

This the (short, funny, sad) video we got to see on imaging women's brains at the CZI Imaging meeting as part of Nina Miolane's talk. Worth a few minutes and worth a share. www.youtube.com/watch?v=tX5u...

🚨 Attention #teamtomo PhD students! 🚨 12-week paid internship opportunity at Genentech. Want to see how we use cryoET in pharma? And spend the summer 2025 in the Bay Area? Details and application link here: roche.wd3.myworkdayjobs.com/ROG-A2O-GENE...

Action Intent Links | Bluesky Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:

docs.bsky.app/docs/advance...

#AcademicSky #HigherEd #Altmetrics

📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.

Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj

Let's make ChemBioSky even greater again!

#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️

🔄Share to help people finding its topic/field

- STRUCTURAL BIOLOGY

Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...

📌

Thanks! Would you mind adding me as well?

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

📌

I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know

Thousands of published studies may contain images with incorrect copyright licences Questions raised over copyright licence that covers images created using scientific illustration service Biorender

More than 9000 studies published in open-access journals contain figures created using the commercial scientific illustration service BioRender, which should technically mean that they are available for free reuse. But that doesn’t appear to be the case.
www.chemistryworld.com/news/thousan...

Love to join as well 👩🏼‍🔬 I’m a PostDoc in Chemical Biology

I’d love to join! I’m a PostDoc in chemical biology at EPFL. Thanks for the organisation.

people.epfl.ch/pauline.fran...

scholar.google.com/citations?us...

Here is a starter pack dedicated to fluorescent probes, sensors and fluorophores makers.

I'm sure it's incomplete, please reply to this post to be added or suggest someone.

go.bsky.app/MtgJE4w