Daniel D. Azorín

YouTube video by BrainPrize The value of perseverance in science

“Basic science often gives you a hard time. There are periods, weeks, even months, sometimes years, where you are not moving forward. But in the end, the rewards are enormous” Frank Winkler, prof. of Neuro-Oncology, Brain Prize winner 2025.

#Neuroscience #TheBrainPrize

youtu.be/7_CZz4gFyqU

Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social

We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.

Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery

Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth - Nature Cancer Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.

📢New Article now published at Nature Cancer!

'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth'

✏️By Tian-Ming Gao, Jian-Ming Li and colleagues

🔗 www.nature.com/articles/s43...

We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:

Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

Molecular recording of cellular protein kinase activity with chemical labeling:

www.nature.com/articles/s41...

Congratulations to De-en Sun and the entire team.

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...

Need a distraction to shift your TMEntality today?
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...

The EACR Cancer Neuroscience conference 14-16 October 2025 is open for registrations. Please bear in mind that the abstract deadline is June 30th 2025. We will be selecting a number of short talks from the abstracts! eacr.org/conference/c...

Pinpointing neurons that hinder cancer treatment Method to identify neurons associated with pancreatic cancer.

and the News & Views: www.nature.com/articles/d41...

I am happy to share our PDAC study, led by @verat-h.bsky.social.

I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience.

Full text here: www.nature.com/articles/s41...

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...

Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies Abstract. Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contrib...

Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies | Cancer Discovery | American Association for Cancer Research
#paper

aacrjournals.org/cancerdiscov...

So many nice starter packs.. I couldn't find one related to spatial biology yet, so I started one 🧬🔬! Here's who I’ve included so far—let me know if you'd like to be added or suggest other must-follow accounts! #SpatialBiology

go.bsky.app/SU34ELC