Iva Gasparovic-Curtini

Day 1 of ECTRIMS SS in Stockholm on the subject of visual pathway pathology and diagnostics in MS and adjacent disorders, valuable discussions and workshops with renowned speakers and facilitators. Visual pathology is smt. complex. How do we analyse and understand it for the better of our patients

So happy I had a chance to contribute to this wonderful CLINNOVA Initiative and to be able to do the ideology and program a part pertaining to the Mannheim Centre. This slit the first AI door to me, while the work at Dresden C. for neuroscience enriched it tremendously. What would our ancestors say

(A and B) Approved therapies in liquid tumors target malignant B cells and plasma cells through CD19 and BCMA (A), whereas clinical studies in solid tumors target antigens such as cMET and mesothelin (B). (C and D) In autoantibody-associated autoimmune diseases, such as SLE (C) and MG (D), CARs targeting both CD19 and BCMA are being investigated. Specifically, disease is driven by autoantibodies produced by B cell–derived plasma cells that result in attack of ubiquitous nuclear antigens during SLE and neuromuscular junction antigens during MG.

Scientists have made major strides in engineering #CARTcell therapies to treat autoimmune disorders such as lupus, according to a 2024 #ScienceTranslationalMedicine Review that discusses recent breakthroughs and clinical trials in the field.

Learn more on #WorldLupusDay: scim.ag/3RTF3HC

Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother

Don’t ever let the naysayers tell you it can’t be done - of course it can!

#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰

Astonishing insights from a new study by Juan M. Barba-Reyes, led by Ana B. Muñoz-Manchado, reveal oligodendrocyte vulnerability and impaired myelin integrity in Parkinson’s D. using transcriptomics. A such an important finding

#ParkinsonsDisease #Oligodendroglia #Transcriptomics #Neurodegeneration

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis Inflammation and glutamate excitotoxicity are the major drivers of neuronal cell death in multiple sclerosis (MS). This study identifies neuronal STING as a central regulator of inflammation-induced n...

Apparently the brain whispers long before symptoms appear.
This new paper signals that inflammation does not just come as a loud storm. Are we waiting for one? The study shows how inflammation triggers STING accumulation in neurons, leading to damages of neuronal tissue.
www.cell.com/cell/fulltex...

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations - Nature Analysis of a large ancient genome dataset shows that genetic risk for multiple sclerosis rose in steppe pastoralists, providing insight into how genetic ancestry from the Neolithic and Bronze Ag...

We all, now and then, dig deeper into the roots—whether our own or those of humanity. This interesting paper delves into the roots of MS genes, and it is astonishing to see the path they took and how they dispersed

www.nature.com/articles/s41...

A new paper. The authors utilized advanced imaging techniques- TSPO-PET, to characterize a new lesion phenotype containing a broad rim of myeloid cells found to correlate strongly with disease progression and lesion load, a potential biomarker of disease progression
www.nature.com/articles/s41...

Criteria and order of authorship on a research paper This blog post explores ICMJE guidelines on ethical authorship, order of authors, and more.

✍️What’s the order of authorship in scientific manuscripts? And who’s the corresponding author? Our blog post explores ICMJE guidelines on ethical authorship, order of authors, and more.📖
#research #science #academia #AcademicSky #AcademicChatter #SciSky #PhDSky #PhDChat #MedSky #SciComm #eloquenti

15 positions of Fellow in AI in Paris (teaching + research positions)

Required field(s) of studies: mathematics, computer science, physics, astrophysics, chemistry, life sciences, cognitive sciences, etc.

prairie-institute.fr/fellow-in-ar...

Disability improvement Is multiple sclerosis a progressive, irreversible, unidirectional disease?

#MS_Selfie Newsletter - Disability improvement

Is multiple sclerosis a progressive, irreversible, unidirectional disease? Please have your say => buff.ly/TmaoAYi

ICYMI: New online! Neurofilament light chain induces neuroinflammation

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...