Harihar Mohan

Releasable SNAP-tag Probes for Studying Endocytosis and Recycling Site-specific labeling of cellular proteins with chemical probes is a powerful tool for live cell imaging of biological processes. One popular system, known as the SNAP-tag, is based on an engineered ...

How about a SNAP or tetracysteine tag? pubs.acs.org/doi/10.1021/...

It was a pleasure working with you and Martin!

Virus-like proteins help our cells respond to environmental stress
www.science.org/doi/10.1126/...

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology Virus-like proteins help our cells respond to environmental stress.

Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules

www.science.org/doi/full/10....

Thank you, Chelsey!

Thank you and no worries, Mara!

Earlier this month, I defended my PhD in front of friends and family. As a teenager, I dreamed of this moment and I’m glad it finally came true. Thanks to my mentors, Drs. Paulson and Sharkey and my committee members! I will be starting a postdoctoral position in Dr. Roy Parker’s lab at CU Boulder.

Title: SOME GRAMMATICAL VOICES FOR USE IN SCIENTIFIC WRITING ACTIVE VOICE e.g. Our team collected samples and then we tested them. CLICKBAIT VOICE e.g. We collected some samples... You won't believe what happened next! PASSIVE VOICE e.g. Samples were collected and tested. HAIKU VOICE e.g. Quiet science lab. Workers arrive with samples. The testing begins. PASSIVE-AGGRESSIVE VOICE e.g. We did all the collecting and testing. No need to thank us. Just doing our job. CONSPIRACY VOICE e.g. Mysterious "Samples" were harvested and covertly "tested" by so-called scientists.

My latest @newscientist.com cartoon

Wow, really stunning pictures!

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically

connecting ‘cell surface RNA biology’ to cancer biology

@natbiotech.nature.com
www.nature.com/articles/s41...

Mismatch repair inhibitors lift off in Huntington’s - Nature Biotechnology Startups targeting DNA repair seek to build on recent findings that neurodegeneration in Huntington’s disease is triggered only after CAG triplet repeats reach a critical threshold.

Mismatch repair inhibitors lift off in Huntington’s www.nature.com/articles/s41...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

Really cool finding about how VCP protects against bacterial pathogens…

Reprogramming site-specific retrotransposon activity to new DNA sites - Nature A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵

www.nature.com/articles/s41...

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers https://www.biorxiv.org/content/10.1101/2025.04.07.647611v1

Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob
www.nature.com/articles/s41...

Now we’re able to edit proteins directly! Really cool stuff!

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.

Enables ‘watching’ of RNP assemblies inside living cells

Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

https://go.nature.com/4iECjJz

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

March 21, 2-3 pm ET: What to do when your federal grant has been stopped or terminated

If you have a federal grant, I *highly* recommend going to this Friday's webinar on responding to grant terminations.

Lisa Brown, former general counsel at Dept of Ed, will present along with other lawyers.

Friday, March 21, 2-3 pm. More info & register here: www.linkedin.com/pulse/regist...

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

This is so cool. Do you think it would work to segment and quantify 3D STED images?

Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

High-quality manuscripts complement scientific value and readability

"Views and suggestions for young scientists and early-career researchers on how to prepare a high-quality manuscript."

PDF:
www.cell.com/action/showP...

Gosh, sounds like a nightmare…

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification - Nature Neuroscience Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and loc...

This is going to be an important paper for years to come in the HD field!

www.nature.com/articles/s41...

I wonder if in the future we could take a CRISPRi pill along with penicillin to get rid of a UTI

Fascinating RNA-mediated changes in memory!