I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.

They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1

An Interview with Dr. Bergquist and Dr. Moreau: From Genes to Proteins to Neuroinflammation In this interview, Jonas Bergquist, MD, PhD, and Alain Moreau, PhD, two of OMF’s Directors, discuss their main ideas behind ME/CFS, including an immune system that is too active in the brain and spinal cord, inherited factors, and how genes are expressed. Every dollar fuels groundbreaking research to find life-changing answers. All donations to OMF are tripled from November 1 through December 2, 2025.

Dr Jonas Bergquist & Dr Alain Moreau discuss their main ideas behind ME/CFS, including an immune system that is too active in the brain and spinal cord, inherited factors, and how genes are expressed. [23 mins] +Transcript
tinyurl.com/59hjxjjs

Solve-Funded Study Finds Posture and Sex Affect Cardiometabolic Health in People with ME/CFS - Solve ME/CFS Initiative Results from a Solve Ramsay Research Grant-funded study suggest that sex and posture significantly influence cardiometabolic health in ME/CFS and that antioxidant treatments for ME/CFS may help men mo...

Dr Francisco Westermeier's team has found that ME/CFS affects the cardiometabolic health of women differently from how it affects the health of men and suggests that antioxidants may help men with ME/CFS more than women with ME/CFS.
tinyurl.com/5ddkjuc3

Does anyone know what percentage of MECFS patients don't experience pain at all?

I don't have pain. I don't have anxiety. I don't have depression. The central sensitization theory just doesn't match my symptoms.

“Imagine plugging in a dead cell phone over night. When you awake, you expect it to be at 100%. But when you wake, it’s only at 9% and you have to try and function on that 9 percent. You’re never fully charged.” https://buff.ly/3rRDYWM #chronicillness #severeME #pwME #pwLC

⏳ The #YEVienna2025 workshop is happening next week!

Next up in our speaker highlights is Dr Eva Untersmayer-Eisenhuber ✨

She’ll present “From basic research to clinical application: translation of interdisciplinary research in ME/CFS”.

Ritz Carlton has built a high-end lodge on the grand migration route, Maasai Mara Kenya.

Maasai leaders seek legal redress but also experiencing challenges. They need international support.

Hope this story gains wider coverage, as the climate impacts are also relevant.

bsky.app/profile/juli...

The Government Has Cut Air Pollution Funds to Councils by 99% as Illegal Levels of Pollution Shorten Lives New data shows just £1.5 million was given to councils in England in the past year to tackle air pollution - down from a high of £225 million in 2021

🔴The Government Has Cut Air Pollution Funds to Councils by 99% as Illegal Levels of Pollution Shorten Lives

New data shows just £1.5 million was given to councils in England in the past year to tackle air pollution – down from a high of £225 million in 2021

bylinetimes.com/2025/11/21/t...

friendly reminder, you can stand up for immigrants without tying our worth/intrinsic value to our labor

Coverage of the refugee proposals demonstrates why we have such a broken political system. Endless focus on left-wing anger and right-wing support. Basically nothing on whether the reforms will work. They will not, which is why we'll still be here having the same debate in three years.

A historic step for ME/CFS and Long COVID research – scientific integrity must take precedence. 🧠 The German government’s commitment of €500 million for Long COVID and ME/CFS research marks a historic milestone. This funding offers an unprecedented opportunity to develop validated diagnostic tools and curative treatments. It is imperative that these funds are allocated to evidence-based, high-quality science. The current NICE guidelines (UK) reviewed 236 studies on cognitive behavioral therapy (CBT) and graded exercise therapy (GET) – not a single one demonstrated even moderate-quality evidence. Such approaches can no longer be legitimized as viable treatments. Science owes progress to patients – not the repetition of past mistakes.

A historic step for ME/CFS and Long COVID research – scientific integrity must take precedence. 🧠

Science owes progress to patients – not the repetition of past mistakes.

If you use prodrome products you can get 35% off now with our affiliate code FALOR35. The affiliate income goes to our non-profit which is a way you can help us.

Please like and share widely to help us fund research, education and care in MECFS, Long Covid & associated conditions

Using Golden Ticket to describe people who have fled war and destitution to legally seek asylum. An internationally recognized legal right that the UK is treaty bound to recognize is pure cruelty and evil. It is the language of Nazis, of deportations, of camps and life unworthy of life. Evil.

1) This study from Cornell University tested more than 6000 proteins before and after two exercise tests.

It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.

💙🫂

Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion The overarching symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), an exacerbation of symptoms following physical or mental exertion. To investiga...

Temporal dynamics of the plasma proteomic landscape reveals maladaptation in #ME/CFS following exertion
Arnaud Germain ∙ Katherine A. Glass ∙ Melissa A. Eckert ∙ Ludovic Giloteaux ∙ Maureen R. Hanson @cornellmecfs.bsky.social

Department of Molecular Biology and Genetics, Cornell University

Thanks Chris. Appreciate you taking the time to answer.

I know it's cynical (it's my 12 year MECFS anniversary this month so I'm working through some things mentally and emotionally) but do we even know this is for biomedical research? Or will this just be spaffed up the wall on more exercise and brain re-training/CBT trials?

Investigating PEM via Muscle Biopsy in ME/CFS and Long COVID - Open Medicine Foundation The study explores the pathophysiology of post-exertional malaise (PEM), the hallmark symptom of ME/CFS.

Update on Dr. David Systrom Study led by Harvard MECFS Collaboration

A cardiopulmonary exercise test with muscle biopsy reveals reduced mitochondrial biomass and disturbed mitochondrial function in skeletal muscle.

www.omf.ngo/investigatio...

Sure but people who had loving, safe, attentive childhoods still end up with ME so it's clearly not causal.

Thank you @sunsopeningband.bsky.social @scheibenbogen.bsky.social @marydimmock.bsky.social @workwellfoundation.bsky.social et al. 💙💙💙🙏🏻💙💙💙

Once again and I repeat myself: the best research which came out of the NIH Intramural study, as an offshoot, was P. Hwang et al. 2023 paper on WASF3 in the muscles of #pwME. Published in @pnas.org

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in #ME/CFS

9) But once they have those genes, he said, they will be knocking on the doors of experts in those genes in the field of neurology and immunology and say: "We know you’re a busy person, but you should be working on ME/CFS."

1) Another interesting interview of Prof Chris Ponting by David Tuller.

They talked about PRIME, a new 4-year project that will provide an infrastructure to accelerate ME/CFS research. It received 0.8 million in funding from the Medical Research Council (MRC).

So proud to be amongst a community so dignified and respectful despite being so badly wronged, badly represented and unjustly served. Strength in our numbers #pwME #LongCovidME. Thank you 🏴󠁧󠁢󠁷󠁬󠁳󠁿
@ashleydaltonmp.bsky.social we can help you. Please accept our offer of support.
Justice4ME.uk 🙏🏼🙏🏼

🤡🤡🤡

Labour + Streeting launching review into "over diagnosis" of mental health/neurodiverse conditions.

Simon Wessely been given vice chair position for it.

Excited for Cass 3.0 🫠🫠🫠

How many more lives is Simon Wessely going to wreck before he retires?!?! #pwME #MECFS

You'd think that someone who had got things so stunningly, utterly, cruelly wrong in his unfounded, unscientific beliefs about ME would be discredited.

Again he'll claim people have a "false illness" belief

3) Speakers include Alain Moreau, Rob Wüst, Todd Davenport, Akiko Iwasaki, Anne Maitland, David Putrino, Michael VanElzakker, and Maya Dusenbery (Author of the book “Doing Harm).