Michalis Averof

If we gave a machine these properties it would still be serving our goals, not their own, right? I think 'agency' implies having your own interests/purpose. But we must have that discussion live, not here...

interesting article by @yoginho.spore.social.ap.brid.gy

Artificial Intelligence is algorithmic mimicry: why artificial “agents” are not (and won’t be) proper agents

arxiv.org/pdf/2307.07515

Cool collaborations on light sheet microscopy @huiskenlab.bsky.social, cellular barcoding @mgrillo.bsky.social, AI-based cell tracking @jytinevez.bsky.social, and citizen science through video game for cell tracking @rebelpixel.fr

see www.averof-lab.org/pages/tracman

3/3

Postdoc will:
* Βe trained in live imaging & transgenic approach
* Generate fluorescent markers for sensory organ cell types (neurons, setae, support cells & glia)
* Develop recombinase-based cell barcoding
* Use barcoding, live imaging & cell tracking to identify regenerative progenitors

2/3

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale

apply here: www.averof-lab.org/pages/tracman

1/3

localized to the plasma membrane? ;)

X-ray imaging of crustacean legs at the DESY synchrotron, Hamburg. Cross-section of regenerating Parhyale leg (~1/10 of a mm in width). X-rays give accurate 3D view with almost cellular resolution. With Angelika Svetlove, Kevin Grüner & Mathilde Paris @zoocell.biologists.social.ap.brid.gy

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

We describe the nucleus as the administrator of the cell. It shares two attributes with administrators: it perpetuates its kind & defies so successfully all efforts to learn what it is doing that only by trying to get along without it can we satisfy ourselves that it is working at all (D.Mazia 1962)

very interesting, thank you!

Thanks and congratulations to everyone involved in this work. Grateful to EU @erc.europa.eu and France @agencerecherche.bsky.social for supporting this project. 6/6

Our next objective: develop fluorescent markers to identify & track the progenitors of every cell type in the leg, starting from the cells that make up the leg's sensory organs. Watch this space for a postdoctoral opening in fall. bsky.app/profile/mich... 5/6

Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs Live imaging allows tracking cellular behaviours and cell fates during the entire course of leg regeneration, spanning approximately one week, in a crustacean model.

In the latest paper, @cagricevrim.bsky.social, @berylbiologist.bsky.social‬ & Ko succeeded in imaging the entire course of leg regeneration and @mlrusciano.bsky.social‬ & @almazan.bsky.social developed HCR to identify specific cell types after imaging. elifesciences.org/articles/107... 4/6

Tracking cell lineages in 3D by incremental deep learning Incremental deep learning enables accurate tracking of cell lineages in 3D with a modest investment in time and effort.

Next, Ko Sugawara developed the Elephant software to use AI for tracking cells. Elephant performs deep learning in an incremental/interactive manner, improving the software as the user checks and corrects the predicted tracks. elifesciences.org/articles/69380 3/6

Live imaging reveals the progenitors and cell dynamics of limb regeneration Long-term live imaging reveals the dynamic cell behaviors and progenitor cells that underpin the regeneration of adult limbs in the crustacean Parhyale hawaiensis.

This work started nearly a decade ago, when Frederike Alwes developed a method for immobilising the legs of transgenic Parhyale under a confocal microscope. elifesciences.org/articles/19766 2/6

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

We'll be looking for a postdoc to bring these approaches together, funded for 3+ years. If you are interested please get in touch; if you know someone who might be interested please share this message. 3/3

for light sheet microscopy w. Flamingo team @metteh-thorsager.bsky.social, genetic barcoding w. @mgrillo.bsky.social, and a video game for cell tracking w. @jytinevez.bsky.social. We'll apply these tools to discover the progenitors for sense organ regeneration in Parhyale. 2/3

We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3

including "panoramic" key regulators, a new term in the hype toolkit ;)

John Maynard Smith on natural history.

(London Review of Books, April 1982)

diverse body shapes of Trichoplax, from small pancake to irregular spaghetti

Expression of clock genes tracks daily and tidal time in brains of intertidal crustaceans Eurydice pulchra and Parhyale hawaiensis Intertidal organisms, such as the crustaceans Eurydice pulchra and Parhyale hawaiensis, express daily and tidal rhythms of physiology and behavior to …

In the brain of intertidal crustaceans (Eurydice and Parhyale), circadian clock genes are expressed with a daily rhythm (24h) in some cells and a tidal rhythm (12.4h) in other cells. Two different clocks working in the same brain, using the same components.

I think you can also get eduroam in swedish airports

Trichoplax adhaerens is one of the simplest and most enigmatic animals on earth. Its body shows incredible fluidity, changing shape within minutes. In a recent visit by Andrea Pasini we had the chance to host and observe these amazing animals live.
[movie accelerated 3x; animal 0.5 to 1 mm in size]

Cartoon of autonomous and light-modulated spwning cycles in Clytia IZ-D

Intriguing findings from our Sendai collaborators Ruka Kitsui and Ryusaku Deguchi. While C. hemispherica spawns at dawn, Clytia IZ-D species spawns at dusk. This is not triggered by dark but, unexpectedly, by light-mediated extension of an autonomously-running 20h cycle. doi.org/10.1101/2025...

"To show our solidarity with our colleagues in the United States who live in fear, and to raise awareness of the abuses that are taking place, fortunately on a much smaller scale but still worrying, in Europe and France."

#StandUpForScience Lyon France

Yes, one can count many scientists among those who fought fascism. I like the example of Monod because he was an active researcher at the same time as he participated in the resistance. I think Jacob fought in WWII and became involved in research later.

I prepared these as banners for the #StandUpForScience demonstration on Friday. Happy to share the high-res files, if anyone wants to use them.