Computational Biology Dpt at Pasteur

YouTube video by European Commission From Ancient Bones to Modern Insights: Argentinian Scientist Uncovering History of Disease in Paris

www.youtube.com/watch?v=hMH1...

I am very thankful to the @ec.europa.eu for highlighting my research at @institutpasteur.bsky.social . It is a privilege for me to have the opportunity of developing my professional life here.

Super cool to see scPRINT, work of my team led by @jkobject.com, featured by @cnrsbiologie.bsky.social

To access the work www.nature.com/articles/s41...

Two weeks ago, I had the pleasure to discuss the research activity of my team @institutpasteur.bsky.social in the panel discussion "How is AI and data-driven innovation reshaping oncology" at @parissaclay.bsky.social SPRING 2025 in @ecolepolytechnique.bsky.social

#ParisSaclaySPRING #SPRING25

David Bikard has been awarded the EMBO Gold Medal in recognition of his pioneering work on gene editing, including his recent editing of a target bacterial population directly in the gut of mice.

🥇Congratulations to David Bikard @dbikard.bsky.social on winning the EMBO Gold Medal!
Well-deserved recognition for advancing synthetic biology and microbial genetics. 🔬✨ @embo.org www.embo.org/press-releas...

Polygenic risk score prediction accuracy convergence Polygenic risk prediction has the potential to transform the diagnosis, treatment, and prevention of many common human diseases. However, the timescale and breadth of this transformation is partly unk...

This long-shot paper aimed to assess whether common GWAS pipelines are reaching their limits for prediction purposes. The review process was lengthy and painful. We're curious to see how it will fly! All comments are welcome! www.cell.com/hgg-advances...

The dpt is pleased to host John Lees, group leader at EMBL-EBI, for a seminar today (24/04) about the bacterial accessory genome adaptive! research.pasteur.fr/en/event/dep...

Excited to see scPRINT published in @natcomms.nature.com ! scPRINT is a large cell model for the inference of gene networks pre-trained on 50Mcells with innovative pretraining tasks inspired from biology. Work led by @jkobject.com

Looking back at 20 years of Open Access publishing at Nucleic Acids Research When Nucleic Acids Research (NAR) was launched in 1974, the concept of an Open Access publication model was not on anyone’s radar. Instead, the focus was o

Always had a soft spot for @narjournal.bsky.social . Not just because I got my 1st first author paper there, but because they were the first traditional journal I knew that went for full open access. It was 20 years ago. Here's Richard Roberts editorial (in OA 😉): doi.org/10.1093/nar/...

Pour ou contre l'IA? "Ne pas confondre recherche et précipitation", par @chtruchet.bsky.social dans @maglarecherche.bsky.social www.larecherche.fr/intelligence...

Got invited with @Nucleate, to the @McDermott conference on health and life science last week.
web.cvent.com/event/....

Loads of important business insights from leaders in the field!

Great to see this in its final form: our study showing that antibiotic resistance genes are more often found in families of plasmids that evolve faster than average (in terms of gain/loss of genes, homologous recombination...). Kudos to @charlescoluzzi.bsky.social now Junior Chair Professor @ U Lyon

📢Here WE go!!! AI for life sciences course kicking off at @pasteur.fr with a lecture from @laineelodie.bsky.social.

Happy to see so many students on campus interested in AI!
@bonomimax.bsky.social @pasteuredu.bsky.social

Avatar Medical, a spin-off from the Institut Pasteur, receives CE marking for its innovative solution «AVATAR MEDICAL Vision » Avatar Medical Vision enables real-time conversion of patients' 2D medical images (such as MRIs and CT scans) into 3D, thus improving visualization and understanding of the patient's state of health. ...

Avatar Medical, a spin-off from the Institut Pasteur, receives CE marking for its innovative solution «AVATAR MEDICAL Vision ». Avatar Medical turns 2D medical scans into 3D visuals, giving surgeons and patients clearer health insights. #MedTech

Take note, the next Pasteur Qbio mini-symposium "Simulated Bodies - Simulated Processes" is taking place on March the 12th!

The Evo 2 authors join us tomorrow in the reading group to discuss their paper: "Genome modeling and design across all domains of life with Evo 2" www.biorxiv.org/content/10.1...

Join on zoom (Monday) at 9am PT / 12pm ET / 6pm CET: www.biorxiv.org/content/10.1...

Permanent research engineer position as Head of Hub Algorithmics & AI pole - Research The Hub of Bioinformatics and Biostatistics provides analytical support to research units and platforms at the Institut Pasteur. The Hub is committed to this mission through:  As head of the Algorithm...

We're hiring! Join the Hub of Bioinformatics and Biostatistics at @pasteur.fr as the Head of the "Algorithmics, AI, and Mathematical Modeling" pole. 🧬💻 Apply now: hub-jobs2025.pasteur.cloud #Bioinformatics #ScienceJobs

Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal | The EMBO Journal imageimageThe naturally occurring S. cerevisiae 2µ plasmid is one of few documented cases of eukaryotic plasmids, undergoing equal distribution between mother and daughter cells during mitosis. Using ...

Are you curious about eukaryotic plasmids?
PhD student Fabien Girard with Axel Cournac in the lab explore the positioning of plasmid 2u, one of these rare (known) episomes, in the budding yeast nucleus. The results were surprising.
#plasmids #chromatin #3Dgenome

www.embopress.org/doi/full/10....

🔔 Reminder!

🧠🔎 Why do we fall for fake news?

Join philosophers & neuroscientists to explore how our brains shape our perception of truth.

📅 March 15, 2 PM | Hall Duclaux | Institut Pasteur

🎟 Free, registration required: www.eventbrite.fr/e/comprendre...

If you are at @pasteur.fr today, come see @bussigio.bsky.social at 11AM in Salle Retrovirus. You won’t regret it #rna #cryoEM #coolscience @ipdbsc.bsky.social

🧠🔎 Why do we fall for fake news?

Join philosophers & neuroscientists to explore how our brains shape our perception of truth.

📅 March 15, 2 PM | Hall Duclaux | Institut Pasteur

🎟 Free, registration required : www.eventbrite.fr/e/comprendre...

We have updated all Logan contigs (now at version 1.1)! Contiguity has been much improved (2x) and a duplicated k-mers bug has been fixed. More information and changelog here: github.com/IndexThePlan...

Many years to get this one out, while gaining huge respect for people doing clinical trials (perseverance!). We show that antibiotic treatments spur changes in the phage composition of the human gut, with bursts of virulent phages that may facilitate homeostasis. Check Eugen's thread!👇

To conclude our Primer Method winter session, Aimee Taylor will talk about Bayesian models to classify recurrent infections in clinical trial participants. She will present key concepts underpinning these models, focusing on identity-by-descent and sibship graphs.

For today's Primer, @jkobject.com will talk about Foundation models of RNAseq data and biological networks, presenting deep learning and transformer models in the context of single cell data and discussing how to train these models on atlas-scale datasets.

Our Primer Methods session continue! This morning @bonomimax.bsky.social will talk about Bayesian inference in integrative structural biology, presenting theory and applications where different types of experimental data have to be combined to obtain accurate structural models of biological systems

Our Primer MEthod seminar are resuming! Today Jean-Baptiste Masson will talk about variational Bayesian inference, presenting principles and associated methods, and introducing concepts and general approaches to amortized inferences.

A new Primer Method today: Sebastien Duchene will present Bayesian phylodynamic models, discussing the prior distributions of key parameters, and the extent to which they can impact downstream inferences of the evolutionary dynamics of organisms.

This is the weekly anoucement for our Method Primer seminar: next Monday (the 9th), @fredlem.bsky.social will present a Bayesian version of the phylogenetic bootstrap in which alignment sites are assigned uninformative prior probabilities, an approach especially relevant for viral phylogenies!

The Primer Method seminar continue! This morning, we'll have @yoann.bsky.social n.bsky.social who will discuss about computing and querying de Bruijn Graph, including how to transform raw sequence data into k-mer sets, and common ways to store and index sets for queries.

La Fondation des Treilles, un lieu virgilien pour les arts et la pensée Dans « un paysage du bout du monde » situé dans le Haut Var, la Fondation des Treilles est un lieu qui favorise le dialogue entre créateurs et chercheurs.

Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...