Constantin Anoyatis

(p)ppGpp-dependent activation of gene expression during nutrient limitation | mBio Bacteria often experience nutrient limitation and, in response, attenuate energetically costly metabolic processes like protein synthesis. At the same time, however, they stimulate the expression of a subset of proteins that facilitate survival under ...

(p)ppGpp-dependent activation of gene expression during nutrient limitation

#mBio from Jonathan Dworkin

journals.asm.org/doi/10.1128/...

Congrats @herailquentin.bsky.social

Mechanism of lateral cell-wall expansion at a constant diameter in Bacillus subtilis Nature Communications - In Escherichia coli, lateral cell-wall expansion during growth occurs by crosslinking of new glycan chains to the existing peptidoglycan network. Here, Liang et al. show a...

Excited to present our new study on the mechanism of lateral peptidoglycan expansion in B. subtilis. We combined microscopy visualisation with clickable D-Ala-D-Ala analogues and stable-isotope peptidoglycan labelling to describe an inside-to-outside expansion model @natcomms.nature.com.

(p)ppGpp modifies RNAP function to confer β-lactam resistance in a peptidoglycan-independent manner - Nature Microbiology The bacterial alarmone (p)ppGpp induces β-lactam resistance through modification of RNA polymerase and ribosome function rather than regulation of peptidoglycan metabolism in Escherichia coli.

Very excited to share our work on (p)ppGpp-mediated resistance to beta-lactam antibiotics published in Nature Microbiology!! A great outcome for a project we started working on 5 years ago. A big thank you to all authors that participated in this study!

www.nature.com/articles/s41...