once upon a time "...the bacterial ribosome was thought to be composed of a fixed set of ribosomal proteins (RPs) and ribosomal RNA (rRNA), ensuring precise translation"
ribosomologists take note: the role of heterogeneity of the ribosomes in the bacterial stress response π
#RNASky #MicroSky
22.07.2025 10:54 β π 23 π 6 π¬ 1 π 0
Thanks JΓΆrg.
04.07.2025 14:10 β π 0 π 0 π¬ 0 π 0
Thanks Dirk!
04.07.2025 14:10 β π 1 π 0 π¬ 0 π 0
Thanks for that. Will definitely do that next time!
04.07.2025 12:17 β π 1 π 0 π¬ 0 π 0
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
10.06.2025 13:53 β π 112 π 162 π¬ 0 π 8
Robust and resource-optimal dynamic pattern formation of Min proteins in vivo
Nature Physics - Oscillatory Min protein patterns prevent abnormal bacterial cell division. Now it is shown that Min pattern formation is resource efficient and involves wavelength-invariant...
Our paper on the E. coli Min system in vivo with @physicsoflifelmu.bsky.social & Judy Kim (UCSD) has been published in Nature Physics today. Tight integration of experiment and theory, and physiology and biophysics. Incredible perseverance of our young students. rdcu.be/ekIpO
05.05.2025 14:53 β π 36 π 16 π¬ 1 π 2
Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS nΒ°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS nΒ°1 needle (83βnm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50β55βnm) potentially limits additional damage by the T3SS nΒ°3 needle (56βnm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authorsβ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org π§ͺ plos.io/4jXrr9Z
06.05.2025 12:46 β π 48 π 22 π¬ 2 π 4
Checkout out our computational framework for studying toroidal membranes of biological dimensions, present at division and fission sites. We studied lipid behaviour at these sites but also simulated membrane fission. Collaboration with @chrislbgraham.bsky.social and @pstansfeld.bsky.social
06.05.2025 07:09 β π 6 π 1 π¬ 0 π 0
Left: The atomic model of the PS2 lattice is shown in top and side views. PS2 hexamers are repeated in the 2D sheet with a lattice constant of 176 Γ
. Each PS2 monomer is colored and labeled separately within the hexamer, which repeats throughout the lattice (with pore dimensions highlighted). The side view of the lattice shows the smooth surface facing the extracellular space and rough surface with coiled-coil segments protruding towards the MM. Top right: Interactions at the hexameric and trimeric interfaces are stabilized by both hydrophilic and hydrophobic residues. Bottom right: A cell envelope tomogram was used to overlay the cryo-EM structure of the S-layer onto the in situ S-layer tomographic density. A single slice of the tomogram is shown, with the overlayed PS2 S-layer lattice in green and the tomogram in grayscale. The S-layer (surface layer), MM (mycomembrane), IM (inner membrane), and Cytosol are labeled.
The unique #CellEnvelope of #corynebacteria: @tbharat-lab.bsky.social &co map the C. glutamicum cell surface, revealing a patchy S-layer & specific assembly of the PS2 protein, thereby informing our understanding of cell envelopes that contain #MycolicAcids @plosbiology.org π§ͺ plos.io/3Y6JNgw
22.04.2025 15:40 β π 35 π 14 π¬ 1 π 4
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
16.04.2025 07:14 β π 100 π 126 π¬ 2 π 1
The preprint is out now - we describe how Bacillus spores restart energy metabolism as they exit dormancy! Dormant spores are dehydrated, very robust for long periods, but when they sense nutrient availability, they can germinate rapidly to make the most of the favourable environmental conditions 1/
18.03.2025 13:55 β π 10 π 4 π¬ 1 π 1
The Greatwall-symposium
The Great Wall Symposium will take place from 18th to 20th September 2023 at the venue in The Vila GalΓ© Sintra Hotel, in Portugal.
Easter is approaching but so is the abstract deadline for the Great Wall Symposium: May 1st!
If you want a chance to present at the best conference, focused on the Bacterial Cell Envelope, crack on!
Sicily, September 15-17th 2025
thegreatwall-symposium.org
08.04.2025 04:52 β π 4 π 1 π¬ 0 π 0
Schematic illustrating the structural changes undergone by MukBEF SMC complex during DNA capture and ingestion.
How do SMC complexes capture DNA? π§ͺ
Led by Frank BΓΌrmann, Jan LΓΆweβs & Mark Dillinghamβs groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.
Read more: tinyurl.com/4s8nrrkk
#LMBResearch
31.03.2025 14:40 β π 62 π 32 π¬ 1 π 1
Bacterial growth under pressure: the surprising role of membrane microdomains
Bacterial growth under pressure: the surprising role of membrane microdomains
Behind the paper by Dennis Claessen on their recent @naturecomms.bsky.social publication
communities.springernature.com/posts/bacter...
Kitasatospora viridifaciens
01.04.2025 08:04 β π 20 π 12 π¬ 0 π 1
On improving the sustainability of peer review
The term βreviewer fatigueβ has become only too familiar in scientific publishing. This editorial discusses how we can ease the burden on reviewers to make the peer review system more sustainable, whi...
The term "reviewer fatigueβ has become familiar in scientific publishing. In this Editorial, @droutledge.bsky.social & @npariente.bsky.social discuss how we can make the peer review system more sustainable & ways that PLOS Biology is already helping to ease the burden on reviewersπ§ͺ
βΆοΈ plos.io/41YKIRa
26.03.2025 17:24 β π 39 π 9 π¬ 4 π 6
Have you ever seen such a huge biofilm deficiency with bslA mutant of 3610, @bacteriacities.bsky.social?
23.03.2025 13:06 β π 7 π 2 π¬ 0 π 0
Not. Going. To. The. US.
19.03.2025 19:59 β π 0 π 2 π¬ 0 π 0
Left: Structural comparison of ATPΞ³S-DppABCDF and apo-DppBCDF. Clipped view of the outward-facing substrate loading cavity in ATPΞ³S-DppABCDF (left), the outward-facing conformation of ATPΞ³S-DppABCDF (middle) and inward-facing conformation of apo-DppBCDF (right). Below: Two inserts showing distance changes of the two coupling helices in two states. Right: Surface representations of the ATPases in the two states viewed from membrane plane. The RecA-like domain and the helical subdomain are differentiated by color shadings. The rotation of the helical subdomain with respect to the RecA-like domain during transition from the inward-facing conformation (ATPΞ³S-DppBCDF) to the outward-facing conformation (ATPΞ³S-DppABCDF) is indicated.
Bacterial ABC peptide transporters are involved in processes like nutrient uptake. This study solves #cryoEM structures of the #Ecoli dipeptide #transporter DppABCDF in both apo & ATP analog-bound forms, providing insights into assembly & import mechanism π§ͺ @plosbiology.org plos.io/3DxP8pU
12.03.2025 09:01 β π 10 π 2 π¬ 0 π 0
New features in #AlphaBridge implemented by @alvarezsalmoral.bsky.social
π₯ Customisable cutoff-level for filtering on weak (0.5) or strong (0.9) interactions.
π¦ Displaying the ipTM score, and the brand-new "Contact-ipTM and #AlphaBridge scores.
π§ Per-interface #AlphaBridge scores.
19.12.2024 14:48 β π 17 π 5 π¬ 1 π 0
Posdoctoral researcher, candidate for weirdest E. coli mutant, at the Hugonnet Lab in Paris. From autolysin roles to (p)ppGpp-mediated resistanceπ§«
Asst. Prof. at UNIGE
Evolutionary cell biology & multicellular developmental diversity of protists.
www.dudinlab.com
#Ichthyosporea, #Multicellularity, #Evolution, #Embryo, #Development, #Protist, #UExM, #Cytoskeleton, #Actin, #Expansion #Microscopy
Departmental Group Leader - Protein Bioinformatics @ Max Planck Institute for Biology - TΓΌbingen @mpi-bio-fml.bsky.social
Protein evolution // MPI Bioinformatics Toolkit // prokaryotic cell-surface proteins // prokaryotic histones
Lead Scientist at the Division of Intramural Research (formerly NCBI), NLM, NIH. Bacterial signaling, c-di-GMP, c-di-AMP, protein domains, COG database
PhD student having fun with bacterial flagella and biofilm regulation.
CABD, Seville, Spain
I enjoy playing with family, reading science fiction and history, gardening, board games, and jazzercise. I'm a father, husband, Navy veteran, and graduate student studying computer science at George Mason University.
Mastodon: https://scicomm.xyz/@David
π¬ Assistant Prof, Pathology βͺ@Duke | Director, Clin Micro Lab
𧫠Former Clin Micro Fellow βͺ@Memorial Sloan Kettering
π©π»βπ¬ Former Postdoc @broadinstitute.org
π PhD @The Rockefeller University
Focus: Diagnostics, AMR, Structural Biology
Antibiotic Resistance Lab
UMRS 8228 CPCV - Sorbonne University - ENS - PSL - CNRS
INSERM ERL 1336
(Previously Arthur Lab)
Peptidoglycan and antibiotic enthousiasts π¦
Incubated in the Cordeliers site of Sorbonne University.
Assistant professor at Cornell Psychology Department. CoCoCo Lab (Cornell Computational Cognition Lab) @co3lab.bsky.social. I am recruiting!
Scientist. Host-Microbe Interactions. Airway Microbiome. Multi-omics. Asst. Prof @ UMich. PI of @koziklab
Nerd.
https://sites.lsa.umich.edu/koziklab/
Anaerobic Microbiologist | Plant Molecular Biologist | Sustainable Biotech Interest
PhD Candidate
The Kozik Lab @ University of Michigan
Associate Professor of Microbiology
Institute of Biomedical Science - University of Sao Paulo, Brazil
Structural biology/biophysics/Natural products/Tuberculosis lover
Clinical Pathologist: Transfusion Medicine Fellow and Postdoctoral Researcher at Columbia University Medical Center
Biochemist, structural biologist, sometimes bacterial geneticist
Associate Dean | Assistant Professor | Scientist | #HigherEducation | #Academia | #Mentorship | #FirstGen | π΅π· | Opinions are my own
Roaming at the Justus Liebig University in Giessen, Germany. Interested in bacteria, cell biology, motility, phages and the various wonders of life.
Spores, Bacterial S-layers, Cell Envelope & Cell Division. Structural Microbiologist πβοΈπ¬ at Institut Pasteur (Paris). Formerly at VIB-VUB in Brussels (EMBO & MSCA fellow) π«π·π§πͺπͺπΈ
Asst Prof at KU Leuven | Subcellular organization of bacterial replication | Interplay between cell morphogenesis and cell cycle progression/regulation
https://www.goverslab.com/
A blog that aims to share appreciation for the width & depth of microbial activities.
Posts by Christoph, not necessarily the opinion of all team members of Small Things Considered (STC) https://schaechter.asmblog.org/schaechter/
Graduate Student at UTSW - Co-Mentors @AltoLab_Neal , @GammonLab / Arboviruses π¦ Bacterial Effectors π¦ Innate Immunity
