Andy P. Tsai's Avatar

Andy P. Tsai

@andyptsai.bsky.social

Postdoctoral Fellow in Wyss-Coray lab at Stanford Ph.D trained in Landreth/Lamb lab at IUMedSchool

654 Followers  |  345 Following  |  7 Posts  |  Joined: 17.11.2024  |  2.1689

Latest posts by andyptsai.bsky.social on Bluesky

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Join us in congratulating the CCAD Cohort of 2026! We look forward to their innovative contributions to the field of Alzheimerโ€™s disease and the CCAD community.

#CCAD2026 #AlzheimersDisease #NewVisionResearch

17.10.2025 16:06 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Spatial and molecular insights into microglial roles in cerebellar aging https://www.biorxiv.org/content/10.1101/2025.03.01.640978v1

02.03.2025 11:15 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Spatial and molecular insights into microglial roles in cerebellar aging https://www.biorxiv.org/content/10.1101/2025.03.01.640978v1

02.03.2025 11:15 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Simultaneous analysis of single-cell gene expression and morphology provides new insight into how microglia change with age https://www.biorxiv.org/content/10.1101/2025.02.28.640888v1

01.03.2025 11:16 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Simultaneous analysis of single-cell gene expression and morphology provides new insight into how microglia change with age https://www.biorxiv.org/content/10.1101/2025.02.28.640888v1

01.03.2025 11:16 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...

Excited to share this collaborative work led by Guosong Hongโ€™s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum ๐ŸŒˆ

www.biorxiv.org/content/10.1...

28.02.2025 06:39 โ€” ๐Ÿ‘ 97    ๐Ÿ” 31    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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โ€˜Slimeโ€™ keeps the brain safe โ€• and could guard against ageing Slippery proteins in the brainโ€™s blood vessels form a protective barrier that breaks break down with age, studies in mice show.

Slippery proteins in the brainโ€™s blood vessels (vascular glycocalyx) form a protective barrier that breaks break down with age @carolynbertozzi.bskyverified.social #wysscoray @sophiamshi.bsky.social @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...

26.02.2025 17:56 โ€” ๐Ÿ‘ 25    ๐Ÿ” 10    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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Glycocalyx dysregulation impairs bloodโ€“brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimerโ€™s disease, leading to dysregulated bloodโ€“brain barrier function.

Glycocalyx dysregulation impairs bloodโ€“brain barrier in ageing and disease

www.nature.com/articles/s41...

26.02.2025 17:10 โ€” ๐Ÿ‘ 11    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-ฮณ2 to treat Alzheimerโ€™s disease A naturally occurring missense variant of the phospholipase C isozyme, PLC-ฮณ2, harboring a single substitution (P522R) protects against several neurodegenerative diseases, including Alzheimerโ€™s diseas...

Excited to be part of the work-"A high-throughput assay platform to discover small molecule activators of the phospholipase PLCG2 to treat Alzheimerโ€™s disease"- now out in JBC !
Huge thanks to Qisheng and the team for this amazing collaborators! www.jbc.org/article/S002...

26.02.2025 01:32 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Expunging Microglial Lipid Droplets Boosts Phagocytosis | ALZFORUM

Microglia stuffed with fat struggle. Knocking out a lipid-droplet regulator in them boosted their appetite for Aฮฒ and tempered plaque load.

www.alzforum.org/news/researc...

08.02.2025 16:00 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Interested in brain aging? We are super excited to share our new review!!

"Brain aging and rejuvenation at single-cell resolution" ๐Ÿงช๐Ÿง 

Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!

authors.elsevier.com/sd/article/S...

09.01.2025 00:16 โ€” ๐Ÿ‘ 47    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thank you so much!

15.12.2024 19:58 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Dear Anne, If possible, I would like to be added and learn more from scientists in the field of aging! Thank you!

15.12.2024 18:39 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Hi Oliver, if possible I would like to be added! I am a postdoc working on hematopoietic stem cells in brain aging and Alzheimer's disease! Thank you!

15.12.2024 18:38 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Updated Aging Starter Packs to find people and labs who work on aging!!

Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA

Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ

Let me know if you'd like to be added! ๐Ÿ˜€

14.12.2024 18:43 โ€” ๐Ÿ‘ 39    ๐Ÿ” 16    ๐Ÿ’ฌ 23    ๐Ÿ“Œ 6
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Welcome! You are invited to join a webinar: Immunity and Neurodegeneration PIA: APOE and Lipid Droplets. After registering, you will receive a confirmation email about joining the webinar. Experts reveal how APOE influences astrocyte lipid droplets and how microglial lipid droplet accumulation is linked to brain tauopathies. Discover cutting-edge research on the role of lipid metabolism...


๐Ÿ’˜ Celebrate Valentineโ€™s Day with cutting-edge science on APOE and lipid droplets!
Join the ImmunityPIA webinar on 2/14/2025!

๐ŸŽค Speakers:
@cohenlaboratory.bsky.social
Dr. Xu Chen

๐ŸŒŸ Panelists:
Dr. Kimberley Bruce
Dr. Lance Johnson
๐Ÿ‘‰ Register now:
alz-org.zoom.us/webinar/regi...

Donโ€™t miss it!

14.12.2024 08:25 โ€” ๐Ÿ‘ 9    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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CD33 isoforms in microglia and Alzheimer's disease: Friend and foe Alzheimer's disease (AD) is the most common form of neurodegenerative disease and is considered the main cause of dementia worldwide. Genome-wide assoโ€ฆ

It is also a good candidate for Alzheimerโ€™s disease: www.sciencedirect.com/science/arti...!

19.11.2024 18:42 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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