Benedikt Kessler

Many congratulations Emma for your Ph.D.📜 Remarkable contribution to the NLRP3 inflammasome field 👩‍🔬

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

#ChronicPain is considered one of the leading causes of disability worldwide. But for the first time, researchers at @CMD.ox.ac.uk and others have discovered a new genetic link to pain, offering a promising target for treating chronic pain 🧬

Find out more 👉 www.ndm.ox.ac.uk/news/chronic...

Driving Therapeutic Innovation in Neurodegenerative Disease with Hydrogen Deuterium eXchange Mass Spectrometry Human neurodegenerative conditions such as Parkinson’s and Alzheimer’s Disease are characterized by the formation and deposition of toxic protein species which exacerbate neuronal dysfunction, impacti...

Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠

🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:

🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab

Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com

#TPD #ProteinDegradation #Ubiquitin

My time in his lab - which only stretched 6-7 months - has had a lasting impact on my career. It was there, that I fell in love with proteases, I met my later post-doc advisor @mbogyo.bsky.social, performed my first cell culture under guidance of @kesslerbenedikt001.bsky.social, and learned a lot!

Last Saturday, I attended - unfortunately not live, but hybrid - the retirement symposium of Prof. Hidde Ploegh. I enjoyed presentations of @kesslerbenedikt001.bsky.social @mbogyo.bsky.social, Domenic Tortorella, various other alumni of the lab, and of course of Hidde himself

Integrative proximal-ubiquitomics profiling for deubiquitinase (DUB) substrate discovery applied to USP30: www.cell.com/cell-chemica...

Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium Author summary Malaria parasites, like all living organisms, need to regulate their proteins carefully to survive and grow. One important way they do this is through a process called ubiquitination, w...

ABPP reveals novel ubiquitin pathway enzymes in Plasmodium. PLOS Pathogens 21(4): e1013032. doi.org/10.1371/jour...
& Katerina Artanavis-Tsakonas’ lab

Protein waste turned into antibiotics as a defence strategy of human cells Proteasome cleavage changes during infection to generate antibiotics.

Also see the associated News & Views by Tim Clausen for a quick summary: www.nature.com/articles/d41...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!

👉 go.nature.com/43k1a0H

A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle m…

DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...

Tracking E2-specific substrates Nature Chemical Biology - Advanced E2-modified ubiquitin probes enable investigation of E2-selective ubiquitination in cells and the discovery of tyrosine ubiquitination as a modification occurring...

Profiling E2-specific substrates reveals tyrosine ubiquitination rdcu.be/eax1F News & Views rdcu.be/eaw41

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Interesting talk by Hannah Jones at #EFMCISBC25. She talked at the development of a chemoproteomic assay with data-independent acquisition to profile deubiquitinase binders at 100 samples per day with a coverage of 35-40 DUBs. www.mdpi.com/1422-0067/23...

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination

www.nature.com/articles/s41...

From the Kessler Lab & STAMP @darraghobrien.bsky.social: Structural Dynamics of the Ubiquitin Specific Protease USP30-Inhibitor Complex revealed by HDX-MS @cmd.ox.ac.uk shorturl.at/GeImS

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn