Jeremy Day

Miami is hiring a neurobiologist! I am excited to welcome a new colleague to our Neuroscience community! Please share!

miamioh.wd5.myworkdayjobs.com/en-US/miamio...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠

www.nature.com/articles/s41...

It was the highlight of the day! I learn so much from all the expertise on study section, including yours - that part I will miss!

Just completed the last cycle in a 4-year stint as a member of the "Neurobiology of Motivated Behavior" study section, which reviews NIH grant proposals. Each meeting has left me impressed with the dedication and professionalism of fellow reviewers and NIH staff - its been an honor!

In the early 60s, NASA approached 4% of the entire US budget - kinda wild to think of those numbers!

As a neuroscientist, I like to think this may have paved the way for our use of fiber optics in applications that are common in neuroscience, like viewing activity of neurons in real time. From one final frontier to another.

Pretty sure my grandfather, who was a NASA engineer that worked on Saturn and Apollo missions in Alabama in the 1960s and 1970s, would be alarmed to see what’s happening now. This is faded but here is a technical drawing he produced for fiber optic viewing of the liquid oxygen supply for Saturn V.

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

One of my favorite songs too, and pretty timely right now for so many reasons.

10 SEC. 542. In making Federal financial assistance, the 11 Department of Commerce, the National Aeronautics and 12 Space Administration, and the National Science Founda13 tion shall continue to apply the negotiated indirect cost 14 rates for Institutions of Higher Education in section 15 200.414 of title 2, Code of Federal Regulations, including 16 with respect to the approval of deviations from negotiated 17 indirect cost rates, to the same extent and in the same 18 manner as such negotiated indirect cost rates were applied 19 in fiscal year 2024: Provided, That none of the funds ap20 propriated in this or prior Commerce, Justice, Science, 21 and Related Agencies Appropriations Acts, or otherwise 22 made available to the Department of Commerce, the Na23 tional Aeronautics and Space Administration, and the Na24 tional Science Foundation may be used to develop, modify, 143 •S 2354 RS 1 or implement changes to such fiscal year 2024 negotiated 2 indirect cost rates.

🧪 For those following indirect rates (not normally an issue with so much drama!):

Senate bill, out today, seeks to block the admin from making abrupt changes to indirect rates at NSF, NASA, and NOAA: www.appropriations.senate.gov/imo/media/do...

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics Jain et al. profiled 41 classical psychedelics across 318 GPCRs, revealing activity at serotonin, dopamine, and adrenergic receptors. All compounds activated multiple 5-HT2AR signal transduction pathw...

EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT!
www.cell.com/neuron/abstr...

Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in number of research grants issued by federal agencies

NIH has seen a decrease of 57% in the number of awards & 63% in value compared to FY24

Double-blind placebo controlled trial (led by UAB faculty Dr. Timothy Garvey) demonstrates >20% weight loss with co-administration of cagrilintide (which targets amylin receptors) with semaglutide (which targets GLP-1 receptors).
www.nejm.org/doi/full/10....

Microscopy image of single molecule fluorescence in situ hybridization to label population of D1-receptor interface islands in a section of human brain tissue at the level of the nucleus accumbens

Early #FluorescenceFriday! Little pocket of D1 interface islands (my ❤️ for these cells knows no bounds) in nucleus accumbens of human 🧠 labeled with new markers we identified (pre-print coming soon 🤩). Image credit to @lieberinstitute.bsky.social team members Ishbel del Rosario and Svitlana Bach 🔬👩‍🔬🧪

Incredibly well deserved - congratulations!

I've seen some science folks react with relief that the current reconciliation bill doesn't cut NIH spending- of course this is a good thing. But we can't stand by and say this isn't our fight - there's a lot in here that will affect biomedical scientists and some really bad stuff for the country 🧵

At UAB’s annual NINDS/R25 supported NEURAL conference today and excited to learn from all of our internal and external speakers, including Corey Harwell!

Years ago, I made a tester account for this kind of thing. It is following only @NBA and nothing else. It has never posted or interacted with a single tweet.

I just logged on to it. Here’s what the algorithm showed me as I scrolled for 30 seconds.

Lots of feels after finishing my term today as a standing member on the NIH/CSR Molecular and Cellular Neuropharmacology study section. I have learned an enormous amount, and gotten the opportunity to see some extraordinary science. I am definitely a better scientist (and grant writer) from this.

Attacks on science are attacks on making and keeping America great: op-ed "Our American scientific engine ... is good for the economy, it improves lives, and it’s one of the true wonders of the world."

Neuroscientist Kristina Visscher writes, “I’m reaching out to you as a nerdy kid from Northport, Alabama, who – thanks to a great Alabama public education – got a Ph.D. in Neuroscience” @visscherlab.bsky.social
www.al.com/news/2025/06...

Interested in learning more about the neuroscience underlying GLP-1 weight loss medications like Wegovy and Ozempic? Attend this FREE upcoming event featuring UAB expert @andrewhardaway.bsky.social! All Brain Chats are open to the public - we welcome your attendance and questions!

False positives in study of memory-related gene expression - Nature Nature - False positives in study of memory-related gene expression

Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community.

www.nature.com/articles/s41...

Thank you @sfn.org for providing some normalcy during these trying times. 😏 #SFN2025

@alreporter.com @al.com @uabneuro.bsky.social @uabneurorms.bsky.social @uabcnbci.bsky.social

Very striking results from Bruce Bean's lab performing ephys on human DRG neurons with the new pain 'blockbuster' drug recently approved by the FDA. These results show that even the most potent blocking of Nav1.8 may not be sufficient to silence pain neurons.

www.pnas.org/doi/abs/10.1...

Thanks for the comments and questions Leo! We will send some replies. We were very surprised to see that logistic regression almost always beats fancier "machine learning" approaches, both in computational time and prediction accuracy. Sometimes its the simplest tool that gets the job done!

Brain Chats is every first Saturday at 11 AM at Avondale Library. June 7, Dr. Andrew Hardaway will discuss "GLP-1 Medicines: Myths, Truths, and a Tale of Basic Science." Don't miss this opportunity to discuss the fascinating science behind new weight loss drugs with @andrewhardaway.bsky.social

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Had a great time in Dublin for the #EngramsandEnsembles2025 conference - this meeting struck a perfect balance of student, postdoc, and faculty presentations. Thanks to @tjryan.bsky.social, @drchristineannd.bsky.social, and Bruce Hope for organizing such a welcoming meeting.