Hakim Boudrioua

I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social
www.biorxiv.org/content/10.1...

Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections: A Biophysical Study Chronic lung infections caused by Pseudomonas aeruginosa and Burkholderia cenocepacia pose a severe threat to immunocompromised patients, particularly those with cystic fibrosis. These pathogens often...

Happy to share our latest #glycotime work with Sarah, Annabelle and @mariofares.bsky.social Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections @pubs.acs.org |Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

Beautiful structures

Thank you for sharing

New pathoblocker can stop Salmonella infections early on Pathogenic Salmonella injects effector proteins into the cells of the gastrointestinal tract to penetrate and multiply within them.

A new synthetic substance, C26, has been identified to inhibit Salmonella's infection process by targeting the central regulator HilD, offering a potential alternative to antibiotics. doi.org/g9fjsr

🔬 New pathoblocker is to stop Salmonella infections early on

Possible alternative treatment method for infections with antibiotic-resistant germs.

📖 Study: tinyurl.com/2s3u4hwj

#Pathoblocker #Salmonella #Pathogenicity #AMR @dzif.bsky.social @unituebingen.bsky.social @mpi-bio-fml.bsky.social

Schnitt durch ein Protein: Blick ins Innere des HilD-Regulators und auf die Bindungsstelle für den Pathoblocker. Die entdeckte Substanz C26 (blau) bindet an den HilD-Regulator und wirkt als Pathoblocker. Zusätzlich ist die von Alpha Fold vorhergesagte Struktur von HilD abgebildet (schwarz). Modell von Thales Kronenberger. 3D-Visualisierung erstellt von Leon Kokkoliadis/CMFI, Universität Tübingen.

🔬 Neuer Pathoblocker stoppt Salmonelleninfektion, bevor sie beginnt

Mögliche alternative Behandlungsmethode für Infektionen mit antibiotikaresistenten Keimen.

Studie: doi.org/10.1126/scia...

#Pathoblocker #Salmonellen #Pathogenität #AMR @dzif.bsky.social @cmfi.bsky.social @mpi-bio-fml.bsky.social

A synthetic substance, C26, has been discovered to halt Salmonella infections early by targeting the HilD regulator. This novel approach could reshape antibiotic resistance treatment. Read the UofTübingen's press release: www.cmfi.uni-tuebingen.de/en/news-even...

Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity Synthetic molecules targeting HilD provide an antivirulence strategy to disrupt Salmonella enterica pathogenicity.

New hope against #Salmonella: Researchers from @unituebingen.bsky.social have developed C26, a compound that blocks infections early – targeted, gentle, and without disturbing the microbiome. A promising approach beyond #antibiotics.
doi.org/10.1126/scia...

Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity Synthetic molecules targeting HilD provide an antivirulence strategy to disrupt Salmonella enterica pathogenicity.

New research findings!
In a collaborative effort, we report sythetic small molecules that target HilD, the central regulator of Salmonella pathogenicity.
www.science.org/doi/10.1126/...

From a diagnostic and phenotype point of view, yes, vancomycin-variable describes it best. I meant from a mechanism point of view, would latent-inducible make sense?

As if it wasn't complicated enough! That makes “inducible" too broad to capture both immediate and delayed expression.
Latent-inducible van genes?

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Open Postdoc position in Tübingen.
Focus on Legionella genetics, membrane protein biogenesis and secretion.