Wendy Bickmore

Many congratulations

😀

Am I in my office, or in a Disney film? Sometimes Edinburgh just takes your breath away.

Absolutely fabulous- hope you continue to have a wonderful trip.

Why we have to continue with animal testing for medical research | Letters Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments

Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...

Excited to start working on this BBSRC sLola project to decode the semantic rules of large regulatory domains, led by @ferencmueller.bsky.social with colleagues from Birmingham, Manchester, Crick, MRC-LMS and EBI-ENSEMBL

institute-genetics-cancer.ed.ac.uk/decoding-the...

bsky.app/profile/fere...

1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).

Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription - PubMed Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor patient outcome. While previous studies proposed a chromatin-based mobile enhancer model for ecDNA-driven oncogenesis, its precise mechanism and impa …

To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/

I just tried it out on a manuscript I am preparing. Impressed. Succinct summary of major claims and whether they are justified based on experiments done. Even more it pointed out a caveat that I hadn’t thought about and that I can now address.

Chicken and egg - the two are related!!

I’m fascinated to try this. It’s such a relief to see the journey we are on that started with the launch of BioRxiv and that could liberate us from the most depressing aspect of science - “getting published”.

Thanks Hiten!

Thank you Charlene

Thanks Ilya.

Thanks Graham - yes its really though at the moment.

So excited to be funded by @erc.europa.eu to work with this extraordinarily talented group of scientists on the GeneMotors project - unravelling how SMC motors work, how they are regulated and how they regulate gene expression.

@ceesdekker.bsky.social @uoe-igc.bsky.social

Fair smattering of vikings, celts, Picts as well

Probably looking for the K9 methylation.

It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...

We're all ready for #DoorsOpenDays2025 tomorrow and looking forward to showing off a snapshot of the work we do at the Institute 🔬🧬🥼🧪 🧫
@cmvm-edinburghuni.bsky.social

YouTube video by danshoremusic Dan Shore - Nothing Hurts Me More

Dan's latest song, for Stephen Colbert, Jimmy Kimmel, and all the comedians out there--

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

Well, we survived our ERC Synergy interview. So exciting working with this great GeneMotors team of SMC experts @ceesdekker.bsky.social Benjamin Rowland, Leonid Mirny. Here's hoping we can continue working together for the next 6 years.

preparing for our ERC Synergy Grant interview tomorrow!

#rehearsingrehearsingrehearsing

Working class women makes inadvertent mistake and resigns.
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.

www.theguardian.com/politics/202...

Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.

Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins Author summary Some parts of proteins, known as intrinsically disordered regions, do not fold into fixed shapes. Instead, they stay flexible and play key roles in controlling how cells work, often by ...

New paper out today in PLOS Comp Biol:
journals.plos.org/ploscompbiol...

Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.

GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...

www.crowdfunder.co.uk/p/saving-pet...